I really like Karrigell ( http://karrigell.sourceforge.net ). It is, IMHO, the most pythonic framework because all you need to know is the python language. You don't need to learn any template or special language, you only use plain and regular python. It also gives you a lot of freedom when choosing a programming style: you can code python inside html (just like in PHP or ASP) or you can code html within python.
It also lets you map databases to objects and you can use the included database Gadfly or any other that has a python api. The downside: it currectly works with its built-in server, and although you can use it alongside Apache or Xitami, there's still no way to do it with mod_python, and as far as I know, there's no hosting providers with Karrigell instaled. It is being used mainly by people who run their websites from their own computers. -- http://mail.python.org/mailman/listinfo/python-list