I have encountered some problems with PyGTK only when I was trying to install a PyGTK version that was different from the installed GTK+ version. When those both versions were the same, I had no problems at all.
(Another problem with PyGTK is that it's installation is somewhat more complicated that installation of wxPython, but I wrote a script that can download and install PyGTK. The user have to tell where all this stuff should be installed to and the script just does the rest.) Tkinter is out of question. It looks ugly. I'd like to write a program that would look nice. -- http://mail.python.org/mailman/listinfo/python-list