Karrigell is a very good option. Easy to learn and easy to use. In words of his author:
"Karrigell is a simple web programming solution, written in Python. It has been designed to be really simple to use : integrated web server and data base ( gadfly), easy access to environement data and form fields, yet full-featured and powerful : Python script execution in the same process as the server (no CGI), server pages including html and Python code (similar to PHP, JSP, ASP), easy handling of authentication, session management, localization features, etc Karrigell can also work with external web servers : Apache and Xitami are currently supported. All current databases (sqlite, MySql, PostGresQL, etc) can be used with the corresponding Python API's. A convenient way of using databases with a dictionary-like syntax is provided for gadfly and sqlite " -- http://mail.python.org/mailman/listinfo/python-list
