Note that you are comparing ordered sequences, like lists, tuples, strings, etc, and not sets. Something like this can be a little improvement of your code, it avoids building the zipped list, and scans the iterable unpacking it on the fly:
from itertools import izip
def test_sets(original_set, trans_letters):
for elem1, elem2 in izip(original_set, trans_letters):
if elem1 == elem2:
return False
return True
Bye,
bearophile
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