>I have experience with OOP, OOA&D and have about 16 years experience 
>writing various stand-alone, client/server and n-tier business 
>applications. I am getting a handle on Python, and I have written a 
>couple of "faceless" applications with it.

As Bob wrote, wx seems to be the best cross-platform choice.
Regarding 3-tier bussiness apps you should have a look at dabo (based on wx); 
it's not yet mature and esp. strange on OSX, but perhaps you can help them.
Regarding client-server stuff I'd suggest twisted (huge framework of network 
stuff, event based).

see
http://www.wxpython.org/
http://www.dabodev.com/
http://twistedmatrix.com/

Best regards,
Henning Hraban Ramm
Südkurier Medienhaus / MediaPro
Support/Admin/Development Dept.
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