See below for the debug trace. Looks like it finds libusb-1.0, but
claims that it was built using the wrong architecture. When installing
libusb-1.0, I downloaded the source then ran
./configure;make;sudo make install
as usuall, and didn't see any significant errors. Below the pyusb
debug trace, I'll paste the log produced when I install libusb-1.0...

########
# PyUSB debug trace
########
2010-05-06 08:13:16,588 ERROR:usb.backend.libusb10:Error loading
libusb 1.0 backend
Traceback (most recent call last):
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/libusb10.py",
line 588, in get_backend
    _lib = _load_library()
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/libusb10.py",
line 165, in _load_library
    l = CDLL(libname)
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/ctypes/__init__.py",
line 353, in __init__
    self._handle = _dlopen(self._name, mode)
OSError: dlopen(/usr/local/lib/libusb-1.0.dylib, 6): no suitable image
found.  Did find:
        /usr/local/lib/libusb-1.0.dylib: mach-o, but wrong architecture
2010-05-06 08:13:16,690 ERROR:usb.backend.openusb:Error loading OpenUSB backend
Traceback (most recent call last):
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/openusb.py",
line 588, in get_backend
    _lib = _load_library()
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/openusb.py",
line 149, in _load_library
    raise OSError('USB library could not be found')
OSError: USB library could not be found
2010-05-06 08:13:16,693 ERROR:usb.backend.libusb01:Error loading
libusb 0.1 backend
Traceback (most recent call last):
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/libusb01.py",
line 539, in get_backend
    _lib = _load_library()
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/backend/libusb01.py",
line 180, in _load_library
    raise OSError('USB library could not be found')
OSError: USB library could not be found
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/legacy.py",
line 326, in busses
    return (Bus(),)
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/legacy.py",
line 322, in __init__
    self.devices = [Device(d) for d in core.find(find_all=True)]
  File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/usb/core.py",
line 819, in find
    raise ValueError('No backend available')
ValueError: No backend available


########
# libusb-1.0 install log
########

mal:libusb-1.0.8 mike$ ./configure
checking for a BSD-compatible install... /usr/bin/install -c
checking whether build environment is sane... yes
checking for a thread-safe mkdir -p... ./install-sh -c -d
checking for gawk... no
checking for mawk... no
checking for nawk... no
checking for awk... awk
checking whether make sets $(MAKE)... yes
checking for gcc... gcc
checking whether the C compiler works... yes
checking for C compiler default output file name... a.out
checking for suffix of executables...
checking whether we are cross compiling... no
checking for suffix of object files... o
checking whether we are using the GNU C compiler... yes
checking whether gcc accepts -g... yes
checking for gcc option to accept ISO C89... none needed
checking for style of include used by make... GNU
checking dependency style of gcc... gcc3
checking build system type... i386-apple-darwin10.3.0
checking host system type... i386-apple-darwin10.3.0
checking for a sed that does not truncate output... /usr/bin/sed
checking for grep that handles long lines and -e... /usr/bin/grep
checking for egrep... /usr/bin/grep -E
checking for fgrep... /usr/bin/grep -F
checking for ld used by gcc... /usr/libexec/gcc/i686-apple-darwin10/4.2.1/ld
checking if the linker (/usr/libexec/gcc/i686-apple-darwin10/4.2.1/ld)
is GNU ld... no
checking for BSD- or MS-compatible name lister (nm)... /usr/bin/nm
checking the name lister (/usr/bin/nm) interface... BSD nm
checking whether ln -s works... yes
checking the maximum length of command line arguments... 196608
checking whether the shell understands some XSI constructs... yes
checking whether the shell understands "+="... yes
checking for /usr/libexec/gcc/i686-apple-darwin10/4.2.1/ld option to
reload object files... -r
checking for objdump... no
checking how to recognize dependent libraries... pass_all
checking for ar... ar
checking for strip... strip
checking for ranlib... ranlib
checking command to parse /usr/bin/nm output from gcc object... ok
checking for dsymutil... dsymutil
checking for nmedit... nmedit
checking for lipo... lipo
checking for otool... otool
checking for otool64... no
checking for -single_module linker flag... yes
checking for -exported_symbols_list linker flag... yes
checking how to run the C preprocessor... gcc -E
checking for ANSI C header files... yes
checking for sys/types.h... yes
checking for sys/stat.h... yes
checking for stdlib.h... yes
checking for string.h... yes
checking for memory.h... yes
checking for strings.h... yes
checking for inttypes.h... yes
checking for stdint.h... yes
checking for unistd.h... yes
checking for dlfcn.h... yes
checking for objdir... .libs
checking if gcc supports -fno-rtti -fno-exceptions... no
checking for gcc option to produce PIC... -fno-common -DPIC
checking if gcc PIC flag -fno-common -DPIC works... yes
checking if gcc static flag -static works... no
checking if gcc supports -c -o file.o... yes
checking if gcc supports -c -o file.o... (cached) yes
checking whether the gcc linker
(/usr/libexec/gcc/i686-apple-darwin10/4.2.1/ld) supports shared
libraries... yes
checking dynamic linker characteristics... darwin10.3.0 dyld
checking how to hardcode library paths into programs... immediate
checking whether stripping libraries is possible... yes
checking if libtool supports shared libraries... yes
checking whether to build shared libraries... yes
checking whether to build static libraries... yes
checking for inline... inline
checking whether gcc and cc understand -c and -o together... yes
checking operating system... Darwin/MacOS X
checking sys/timerfd.h usability... no
checking sys/timerfd.h presence... no
checking for sys/timerfd.h... no
checking whether TFD_NONBLOCK is declared... no
checking whether to use timerfd for timing... no (header not available)
configure: creating ./config.status
config.status: creating libusb-1.0.pc
config.status: creating Makefile
config.status: creating libusb/Makefile
config.status: creating examples/Makefile
config.status: creating doc/Makefile
config.status: creating doc/doxygen.cfg
config.status: creating config.h
config.status: executing depfiles commands
config.status: executing libtool commands


mal:libusb-1.0.8 mike$ make
make  all-recursive
Making all in libusb
  CC     libusb_1_0_la-core.lo
  CC     libusb_1_0_la-descriptor.lo
  CC     libusb_1_0_la-io.lo
io.c:1674: warning: ‘handle_timeout’ defined but not used
io.c:1688: warning: ‘handle_timeouts_locked’ defined but not used
  CC     libusb_1_0_la-sync.lo
  CC     libusb_1_0_la-darwin_usb.lo
os/darwin_usb.c: In function ‘event_thread_main’:
os/darwin_usb.c:286: warning: cast to pointer from integer of different size
  CCLD   libusb-1.0.la
Making all in doc
make[2]: Nothing to be done for `all'.
make[2]: Nothing to be done for `all-am'.


mal:libusb-1.0.8 mike$ sudo make install
Password:
Making install in libusb
test -z "/usr/local/lib" || .././install-sh -c -d "/usr/local/lib"
 /bin/sh ../libtool   --mode=install /usr/bin/install -c
libusb-1.0.la '/usr/local/lib'
libtool: install: /usr/bin/install -c .libs/libusb-1.0.0.dylib
/usr/local/lib/libusb-1.0.0.dylib
libtool: install: (cd /usr/local/lib && { ln -s -f libusb-1.0.0.dylib
libusb-1.0.dylib || { rm -f libusb-1.0.dylib && ln -s
libusb-1.0.0.dylib libusb-1.0.dylib; }; })
libtool: install: /usr/bin/install -c .libs/libusb-1.0.lai
/usr/local/lib/libusb-1.0.la
libtool: install: /usr/bin/install -c .libs/libusb-1.0.a
/usr/local/lib/libusb-1.0.a
libtool: install: chmod 644 /usr/local/lib/libusb-1.0.a
libtool: install: ranlib /usr/local/lib/libusb-1.0.a
----------------------------------------------------------------------
Libraries have been installed in:
   /usr/local/lib

If you ever happen to want to link against installed libraries
in a given directory, LIBDIR, you must either use libtool, and
specify the full pathname of the library, or use the `-LLIBDIR'
flag during linking and do at least one of the following:
   - add LIBDIR to the `DYLD_LIBRARY_PATH' environment variable
     during execution

See any operating system documentation about shared libraries for
more information, such as the ld(1) and ld.so(8) manual pages.
----------------------------------------------------------------------
test -z "/usr/local/include/libusb-1.0" || .././install-sh -c -d
"/usr/local/include/libusb-1.0"
 /usr/bin/install -c -m 644 libusb.h '/usr/local/include/libusb-1.0'
Making install in doc
make[2]: Nothing to be done for `install-exec-am'.
make[2]: Nothing to be done for `install-data-am'.
make[2]: Nothing to be done for `install-exec-am'.
test -z "/usr/local/lib/pkgconfig" || ./install-sh -c -d
"/usr/local/lib/pkgconfig"
 /usr/bin/install -c -m 644 libusb-1.0.pc '/usr/local/lib/pkgconfig'

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