Hi!
It may help to block with blacklists (i.e. zen.spamhaus.org),
additionally it may help to block IPs without reverse DNS.
  
Using RBL check to using several of them to different blacklist DBs is a must nowadays.
I am not sure if this is really a DDoS, its sounds more like daily life
for any SMTP server these days.
  
Still it happens that a certain e-mail address is used in a huge spammers session, and it might happen for a period of several days this e-mail will receive unusual amount of bounces, fake e-mails and bogus responses (read from AV, AS software, etc.) So it's a kind of DDoS. Thus your server should be able to handle it = add more RAM, put better CPU and so on.
We currently have 3.7 percent of legitimate mail traffic on our servers.
96.3 percent is junk.
  
Right, indeed! Same here.
The blacklists and reverse DNS checks let us drop 91.9 percent of the
connections before SMTP really starts. So our servers have to deal with
only 8% of the connections. Your mileage may vary.
  
This is good. But one should also use other techniques. Add SPF, DomainKeys, DKIM checks and enforce their policies. And the most important, which alone will fight about 70% of RBL-check missed e-mails, is the Graylisting technique. With all this implemented, your mailbox shall hit 2-3 SPAM e-mails per week. Not bad :)
Regards

Alain Wolf

Hope this helps,
and regards!

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