Similar situation, different error. Did upgrade to 28 with the python 
exclusions:

[user@fedora-28 ~]$ sudo dnf --releasever=28 --setopt=cachedir=/mnt/removable 
--best --allowerasing distro-sync -x python2-xcffib -x qubes-gui-vm -x 
qubes-gui-agent

Then:

[user@fedora-28 ~]$ sudo dnf swap python-xcffib python2-xcffib
Error: Failed to synchronize cache for repo 'updates'

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