Just off the bat, the biggest concern is that dGPU: you can't turn it off in 
the bios (as ithet Thinkpad users have reported on /r/thinkpad).

I just ordered the Thinkpad P1 myself, which is the same as the X1 Extreme just 
with ECC and Xeon.

I specifically got it for its 32GB ECC ram for stability, quadro for some light 
modelling and hex core.  I've been using Qubes on a dual core for years with 8 
GB and it's beyond frustrating when running iur if resources (mem and CPU).

Needless to say, it is going to be a challenge. 
 The biggest being dGPU control, hopefully via Bumblebee and Nvidia drivers in 
dom0 (boo, but it's the only way).

After I ordered my P1, I just found out that the Dell Precision 5520 (same as 
the famous XPS 15) had the option to be ordered with no GPU! This means it 
would be perfect for qubes as it's fairly low cost, 32 GB ram (no ECC though) 
and hex core. 

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