Hi: Apologies for asking the following question. As this may sound very basic and stupid for this forum , I honestly do not know how to solve it and I do not have a teacher who can help me understand. I have list of genes (200) that are involved in a particular process and I call this as a ProcSet. From an independent experiment I found that out of 10,000 genes, 1500 are significant and I call these1500 genes as ResultSet. The intersection of ResultSet and ProcSet are 80 genes. That means 40% of ProcSet are significant. How do I calculate that 40% is significant and more than I expect by chance given ResultSet and 10,000 genes I evaluated in the experiment. What I have: n = 200 (ProcSet) p = 0.4 N = 1500 (ResultSet) N1 =10,000 Pn = 0.15 What kind of test will help me know that 0.4 is significant given 0.15. Any suggestions will greatly help me. Thank you. Srini
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