I am getting a warning message when I run lme:
Warning message:
In lme.formula(fixed = value ~ CorT + time + CorT * time, data = GD) :
fewer observations than random effects in all level 1 groups
I don't know what the message means, nor if I need to be concerned about the
message. I would be
grateful if someone could explain the message to me, and tell me if I need to
have concern.
My data and code follows. You should be able to copy, paste and run the code.
(n.b. you will need nlme).
Thank you,
John
library(nlme)
data10 <- structure(list(SS = c(1L, 2L, 3L, 4L, 5L, 6L, 7L, 8L, 9L, 10L,
11L, 12L, 13L, 14L, 15L, 16L, 17L, 18L, 19L, 20L, 21L,
22L, 23L,
24L, 25L, 26L, 27L, 28L, 29L, 30L, 31L, 32L, 33L, 34L,
35L, 36L,
37L, 38L, 39L, 40L, 1L, 2L, 3L, 4L, 5L, 6L, 7L, 8L, 9L,
10L,
11L, 12L, 13L, 14L, 15L, 16L, 17L, 18L, 19L, 20L, 21L,
22L, 23L,
24L, 25L, 26L, 27L, 28L, 29L, 30L, 31L, 32L, 33L, 34L,
35L, 36L,
37L, 38L, 39L, 40L, 1L, 2L, 3L, 4L, 5L, 6L, 7L, 8L, 9L,
10L,
11L, 12L, 13L, 14L, 15L, 16L, 17L, 18L, 19L, 20L, 21L,
22L, 23L,
24L, 25L, 26L, 27L, 28L, 29L, 30L, 31L, 32L, 33L, 34L,
35L, 36L,
37L, 38L, 39L, 40L),
group = structure(c(1L, 1L, 1L, 1L, 1L,
1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,
1L, 2L,
2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L,
2L, 2L,
2L, 2L, 2L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,
1L, 1L,
1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L,
2L, 2L,
2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 1L, 1L, 1L,
1L, 1L,
1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L,
1L, 2L,
2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L,
2L, 2L,
2L, 2L, 2L), .Label = c("Cont", "Inte"), class =
"factor"),
time = c(0L,0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L,
0L, 0L, 0L, 0L, 0L,
0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L,
0L, 0L,
0L, 0L, 0L, 0L, 0L, 0L, 0L, 3L, 3L, 3L, 3L, 3L, 3L, 3L,
3L, 3L,
3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L,
3L, 3L,
3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L,
3L, 6L,
6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L,
6L, 6L,
6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L, 6L,
6L, 6L,
6L, 6L, 6L, 6L, 6L, 6L, 6L),
value = c(2, 1, 3, 6, 1, 5, 4, 4,
3, 4, 5, 8, 4, 4, 0, 10, 3, 0, 4, 6, 7.86633577663451,
14.8276520497166,
5.82301333779469, 6.28030818421394, 7.63550981180742,
7.12941627483815,
14.4640282960609, 8.45473791006953, 9.05422623036429,
10.3654135158285,
7.75828687706962, 9.05671408865601, 9.35509188333526,
8.22054158896208,
5.03435689257458, 14.7296907380223, 6.12912589916959,
10.4857219522819,
13.7229738035239, 13.6259456002153, 7.28073637914354,
5.54352982843898,
8.01713229269774, 13.2061931600758, 3.76887153466896,
10.7523541087606,
9.6018583095559, 9.62481826991277, 8.90923221009558,
8.85276119502607,
10.9778885179292, 13.4521386035968, 9.95012926745246,
7.78767098907235,
5.47606805783807, 16.266090481022, 8.10664718517709,
3.98960108796381,
10.1788924241439, 9.16177207287154, 11.6541174116198,
19.055363149052,
10.4729343696394, 12.9615216852694, 10.3448541992752,
12.1246619594601,
17.9078516870675, 14.1546013378432, 14.3556335566072,
13.7020998307993,
12.2669613611438, 13.6968944583291, 16.0242423205925,
14.1618907899469,
11.6571628686932, 20.6208065318508, 10.5981108892906,
16.506205140693,
19.8382587955876, 18.8215423103255, 13.6293066791555,
10.679427547606,
14.5715854764237, 18.0672964438053, 8.64819129644325,
16.5046323205086,
14.933146372713, 13.0224731390702, 13.1364074268251,
12.7299140722498,
16.3687231173825, 17.3307585790136, 14.8835947338426,
13.7832964561028,
8.18806783970065, 20.4643754783345, 13.927444172043,
7.95214003187942,
15.8500600646401, 14.863828811346, 16.3418851303983,
23.9363727442689,
15.6973592017088, 16.8376901116903, 16.4265975193717,
18.3862045830691,
23.7260777608949, 19.6736595029528, 18.7411384574001,
21.5299075269243,
18.7672717818268, 18.6586905356669, 20.1908194122778,
19.6037057845507,
16.2952035024787, 25.2275624425201, 15.7628539929276,
21.2326533842687,
25.3146615100186, 24.5526929132951),
baseline = c(2, 1, 3, 6,
1, 5, 4, 4, 3, 4, 5, 8, 4, 4, 0, 10, 3, 0, 4, 6,
7.86633577663451,
14.8276520497166, 5.82301333779469, 6.28030818421394,
7.63550981180742,
7.12941627483815, 14.4640282960609, 8.45473791006953,
9.05422623036429,
10.3654135158285, 7.75828687706962, 9.05671408865601,
9.35509188333526,
8.22054158896208, 5.03435689257458, 14.7296907380223,
6.12912589916959,
10.4857219522819, 13.7229738035239, 13.6259456002153, 2,
1, 3,
6, 1, 5, 4, 4, 3, 4, 5, 8, 4, 4, 0, 10, 3, 0, 4, 6,
7.86633577663451,
14.8276520497166, 5.82301333779469, 6.28030818421394,
7.63550981180742,
7.12941627483815, 14.4640282960609, 8.45473791006953,
9.05422623036429,
10.3654135158285, 7.75828687706962, 9.05671408865601,
9.35509188333526,
8.22054158896208, 5.03435689257458, 14.7296907380223,
6.12912589916959,
10.4857219522819, 13.7229738035239, 13.6259456002153, 2,
1, 3,
6, 1, 5, 4, 4, 3, 4, 5, 8, 4, 4, 0, 10, 3, 0, 4, 6,
7.86633577663451,
14.8276520497166, 5.82301333779469, 6.28030818421394,
7.63550981180742,
7.12941627483815, 14.4640282960609, 8.45473791006953,
9.05422623036429,
10.3654135158285, 7.75828687706962, 9.05671408865601,
9.35509188333526,
8.22054158896208, 5.03435689257458, 14.7296907380223,
6.12912589916959,
10.4857219522819, 13.7229738035239, 13.6259456002153),
CorT = c(0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
1, 1,
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0,
0, 0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1,
1, 1,
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0,
0, 0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1,
1, 1,
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1)),
row.names = c(NA,
-120L), .Names = c("SS", "group", "time", "value",
"baseline",
"CorT"), class = "data.frame")
data10
GD2<- groupedData(value~time+CorT+time*CorT|SS,data=data10,FUN=mean)
fit1 <- lme(GD2)
summary(fit1)
John David Sorkin M.D., Ph.D.
Professor of Medicine
Chief, Biostatistics and Informatics
University of Maryland School of Medicine Division of Gerontology and Geriatric
Medicine
Baltimore VA Medical Center
10 North Greene Street
GRECC (BT/18/GR)
Baltimore, MD 21201-1524
(Phone) 410-605-7119
(Fax) 410-605-7913 (Please call phone number above prior to faxing)
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