so (untested) if you did something like

f1 <- read.text("1g.txt")
f2 <- read.text("1n.txt")

for ( a in as.list(f1) ) {

  for ( b in as.list(f2) ) {

ext <- paste0( "/ld/human/pairwise/",
               a,
               "/",
               b,
               "?population_name=1000GENOMES:phase_3:KHV")

r <- GET(paste(server, ext, sep = ""), content_type("application/json"))

# You presumably need to do something with 'r' at the moment its over written by the next loop.. were # you appending it to list.txt? Possibly its just a bit of the R output you want.?

               write(r,file="list.txt",append=TRUE)


  }

}


Are we doing your PhD for you ;-)  Do we get to share ;-)


On 2020-06-19 20:34, Ana Marija wrote:
Hello,

I have two files (each has 300 lines)like this:

head 1g.txt
rs6792369
rs1414517
rs16857712
rs16857703
rs12239392
...

head 1n.txt
rs1042779
rs2360630
rs10753597
rs7549096
rs2343491
...

For each pair of rs# from those two files I can run this command in R

library(httr)
library(jsonlite)
library(xml2)

server <- "http://rest.ensembl.org";
ext <-
"/ld/human/pairwise/rs6792369/rs1042779?population_name=1000GENOMES:phase_3:KHV"

r <- GET(paste(server, ext, sep = ""), content_type("application/json"))

stop_for_status(r)
head(fromJSON(toJSON(content(r))))
   d_prime       r2 variation1 variation2         population_name
1 0.975513 0.951626  rs6792369  rs1042779 1000GENOMES:phase_3:KHV

What I would like to do is to do is to run this command for every SNP
in one list (1g.txt) to each SNP in another list (1n.txt). Where SNP#
is rs# and output every line of result in list.txt

The process is illustrated in the attachment.

Please help,
Ana

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