Hello,
 
I have a general help question that some of you might be able able to help.

I would like calculate sample size for a study (a two group comparison) based 
on the outcome of reduction on (recurrent) events (say hospital admissions). 

In a previous study, hospital admission rate of 140 admissions per 72 patients 
(over a 4 month period) has been observed. That is rate is about 1.9. In order 
to see the admission rate reduction of 50% over a 4 month period, i.e. 0.95, in 
a two group comparison (alpha 0.05) with appropriate power (say 80%) what sort 
of group sizes are needed.
 
How would I go about this?

Many Thanks,
 
Si.

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