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On Mon, 22 Nov 2004, pcscan wrote:

Dear All:
Significance Analysis of Microarrays(SAM)

As we know sam do multiple t.test as following
## Default S3 method:
t.test(x, y = NULL, alternative = c("two.sided", "less", "greater"),mu = 0,
paired = FALSE, var.equal = FALSE,conf.level = 0.95, ...)

var.equal: a logical variable indicating whether to treat the two variances
as being equal. If 'TRUE' then the pooled variance is used to estimate the
variance otherwise the Welch (or Satterthwaite) approximation to the degrees
of freedom is  used.

We are curious why sam in package siggenes do not have var.equal option ?
Are there some reason ?

sam(data,cl,B=100,balanced=FALSE,mat.samp=NULL,delta=(1:10)/5,med.fdr=TRUE,s
0=NA,alpha.s0=seq(0,1,.05),include.s0=TRUE,p0=NA,lambda.p0=1,vec.lambda.p0=(
0:95)/100,
na.rm=FALSE,graphic.fdr=TRUE,thres.fdr=seq(0.5,2,0.5),ngenes=NA,iteration=3,
initial.delta=c(.1,seq(.2,2,.2),4),rand=NA)

Any help is greatly appreciated.

Sincerely. Liu Yu Ting

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