I whole-heartedly endorse Prof. Ripley's suggestion to write down the log(likelihood) and use optim; I've done that many times with seemingly good results. For confidence intervals, the best procedure is to use 2*log(likelihood ratio) being approximately chi-square. If you are estimating two parameters, you can easily compute log(likelihood) for a grid of points about the maximum likelihood estimates (MLEs) and use "contour" to draw lines at the difference confidence levels. You can also use the argument "hessian = TRUE" to get the observed information matrix and therefore also the covariance matrix of the standard asymptotic normal approximation to the distribution of the MLEs; I've done both.

     hope this helps.  spencer graves

Prof Brian Ripley wrote:

On Sat, 12 Mar 2005, Erin M Simpson wrote:

I am looking for code that allows for a more flexible negative binomial
model (similar to Stata's "gnbreg").


Your subject line is not clear to me: Stata appears to fit a negative binomial model, the point being that it is not a glm as fitted by glm.nb. (So when Stata says

     `gnbreg is a generalized negative binomial regression'

it is `regression' not `negative binomial' that is being generalized.)

In particular, I am looking to be able to model the ancillary
shape parameter in terms of a series of covariates.   So if,

    y[i] ~ poisson(mu[i])

    mu[i] = exp(x[i]beta + u[i])

    exp(u[i]) ~ Gamma(1/alpha, alpha)

I am looking to parameterize alpha as exp(z[i]gamma).

If you are familiar with a package that allows for this, I'd appreciate
the heads up. Similar information that allows for first differences with
such a model is also appreciated.


Just write down the log-likelihood (I am not sure what the free parameters here are: are beta and gamma vectors?), and call optim() to maximize it.


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