Hi R Community. I would like to use smooth.spline to fit a set of data and constrain the endpoints of the fit to have specific derivatives. I know this is possible with cubic splines, but I can't figure out how to specify this with arguments to the smooth.spline function. In general, is it possible to specify a set of "knots" w/locations and derivatives to constrain the fit? I can't find anything about this is the documentation. Thanks!
*********************************** Will Sheffler Baker Lab Dept of Genome Sciences University of Washington Seattle, WA 98195 ______________________________________________ R-help@stat.math.ethz.ch mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.