Hi,
Suppose I have a multivariate response Y (n x k) obtained at a set of predictors X (n x p). I would like to perform a linear regression taking into consideration the covariance structure of Y within each unit - this would be represented by a specified matrix V (k x k), assumed to be the same across units. How do I use "lm" to do this? One approach that I was thinking of is as follows: Flatten Y to a vector, say, Yvec (n*k x 1). Create Xvec (n*k, p*k) such that it is made up of block matrices Bij (k x k), where Bij is a diagonal matrix with X_ij as the diagonal (i = 1,.n, and j = 1,.,p). Now I can use "lm" in a univariate mode to regress Yvec against Xvec, with covariance matrix Vvec (n*k x n*k). Vvec is a block-diagonal matrix with blocks of V along the diagonal. This seems like a valid approach, but I still don't know how to specify the covariance structure to do weighted least squares. Any help is appreciated. Best, Ravi. ---------------------------------------------------------------------------- ------- Ravi Varadhan, Ph.D. Assistant Professor, The Center on Aging and Health Division of Geriatric Medicine and Gerontology Johns Hopkins University Ph: (410) 502-2619 Fax: (410) 614-9625 Email: [EMAIL PROTECTED] Webpage: http://www.jhsph.edu/agingandhealth/People/Faculty/Varadhan.html ---------------------------------------------------------------------------- -------- [[alternative HTML version deleted]] ______________________________________________ R-help@stat.math.ethz.ch mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.