I can't be too much help, but I do remember some previous threads on the racket-users list about using Racket on NixOS <https://groups.google.com/g/racket-users/c/WQ3rFrQHJeA/m/Ib82VVIBBwAJ> and GuixSD <https://groups.google.com/g/racket-users/c/wtQ4-JqyDKw/m/Uj2ihdXVBwAJ>. I'd suggest asking there as well: it tends to be more active than the dev list, and even discussions that get pretty deep in the internals of the implementation are welcome there. There are also some issues at https://github.com/racket/racket (some open, others closed).
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