Dari BBC News kito baco:
Tuesday, June 29, 1999 Published at 11:20 GMT 12:20 UK

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http://news.bbc.co.uk/hi/english/health/newsid_380000/380497.stm

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Mak Ngah

Health

Headache's secrets revealed

Scientists have linked brain structure to brain function

A certain type of headache may be caused by structural
abnormalities in the brain, researchers have discovered.

The finding could revolutionise approaches to
all primary headaches, which had not been
thought to be caused by factors in the physical
structure of the brain.

But using a new scanning technique, doctors
have established that cluster headaches are
likely to be caused by excessive growth of grey cells
in one part of the brain.

It is the section that governs the body clock, which could be
 responsible for the regularity of the headaches' appearances.

Male condition

Cluster headaches are characterised by a sudden excruciating pain
on one side of the head around the eyes, temple or cheek, and can
last for 15 minutes to 3 hours.

Affecting 0.1% of the population - mainly men - they recur over a
period of weeks or months before disappearing, hence their name.


Professor Peter Goadsby, of the
Institute of Neurology, published his
team's discovery in the journal
Nature Medicine.

He told BBC News Online that the
finding revolutionised scientists'
perception of headaches.

"It's like the first time somebody said
the earth was round - you have to
step back and reconsider," he said.

This was because whereas with
secondary headaches - where there
was a known structural cause such
as a brain tumour or bleeding -
primary headaches had been
thought to be caused by chemical
factors alone.

"The dogma is that primary headache, like cluster headaches and
migraine, are due to abnormal brain function with completely normal
brain structure.

"Our study shows this is simply not the case," he said.

Revolutionary discovery

In the past, high-resolution brain scans have shown no abnormalities
in the brain structure of cluster headache sufferers.

But using the latest imaging techniques, Professor Goadsby and
colleagues found an increase of grey matter in an area of the brain
known as the hypothalamus on the side where the headache occurs.

Whereas standard high resolution scans take a picture of the brain
that doctors can examine, the new technique takes pictures of many
brains.

A computer then analyses the pictures down to the finest detail,
making extremely subtle differences apparent.

Because the differences were seen both when the patients were
studied while they had a headache and also in a headache-free
state, changes are likely to be permanent.

Professor Goadsby said: "We also
found that the area of the brain
where these structural abnormalities
were seen, the hypothalamus, is the
same area of the brain where
functional studies show that activity
is abnormal during the headache state.

"This complete correlation of functional and structural
abnormality is striking."

The hypothalamus is the part of the
brain associated with circadian
rhythms - the 24 hour rhythm of the human body.

"Our results demonstrate for the first time the precise
location in the brain involved in cluster headaches
and help to explain why this condition shows such striking seasonal
variation and clock-like regularity," said Professor Goadsby.

 "The findings have profound implications for understanding how the
brain is affected in primary headaches."



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