Hi,
When I use either option -s or -S ,  then I get the same number of counts.
I would expect that the number of counts would be different when the
Minus or plus strand is designated?
Are these options working?
bedtools coverage -abam   -s   -a File.bam -b mm10_all.bed  > File_out.txt

Lana Schaffer
The Scripps Research Institute
Biostatistics, Informatics
DNA Array Core Facility
858-784-2263

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