On 5 Sep 2014, at 06:52, Adam Skarshewski <[email protected]> wrote:
> Running into a problem with samtools 1.0 sort, specifically the merging
> phase. It's very slow compared to the previous version. I have a 965MB bam
> file (which is already sorted)
Does your BAM file have rather a lot of reference sequences? There is a known
problem in the new header merging [1] that we are working on fixing, that
happens when sorting/merging files mapped to thousands of contigs.
John
[1] https://github.com/samtools/samtools/issues/260
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