Hi Siva,

You are trying to open the index file with samtools rather than the bam file. 
Try this instead:
$ samtools view less_stringent_Ha412-34CDSHa.sorted.bam

Same goes for IGV. Point it at the .bam rather than the .bam.bai file.
Regards,

Chris


From:  Siva Nandy
Date:  Tuesday, 19 May 2015 11:10
To:  samtools
Subject:  [Samtools-help] [E::hts_hopen] samtools index problem


>Hi everyone,
>
>I've found a lot's of discussion about this problem, but haven't found the 
>solution.
>I got this error:
>
>[E::hts_hopen] fail to open file 'less_stringent_Ha412-34CDSHa.sorted.bam.bai'
>
>[E::hts_open] fail to open file 'less_stringent_Ha412-34CDSHa.sorted.bam.bai'
>samtools: failed to open "less_stringent_Ha412-34CDSHa.sorted.bam.bai" for 
>reading: Success
>
>
>When I read the sorted.bam file like that:
>-bash-4.1$ samtools view less_stringent_Ha412-34CDSHa.sorted.bam.bai
>
>
>Actually I've done a bwa mapping, and trying to see my mapping results in IGV, 
>so need to have sorted and indexed files of bam.
>
>So got these:
>
>
>-rw-rw-r-- 1 nandy inra 124K May 19 10:33 less_stringent_Ha412-34CDSHa.sam
>-rw-rw-r-- 1 nandy inra 174K May 19 11:21 less_stringent_Ha412-34CDSHa.bam
>-rw-rw-r-- 1 nandy inra  18K May 19 11:22 
>less_stringent_Ha412-34CDSHa.sorted.bam
>-rw-rw-r-- 1 nandy inra 559K May 19 11:59 
>less_stringent_Ha412-34CDSHa.sorted.bam.bai
>
>
>But when in IGV I gave the necessary there is no visualisation, so i think 
>it's maybe because of this error.
>
>regards,
>Siva

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