mpileup is the first step in the calling process, QUAL is calculated by
`bcftools call`.

Please see here
http://www.htslib.org/workflow

Petr

On Tue, 2016-03-22 at 16:08 +0000, Adam Witney wrote:
> Hi,
> 
> I am upgrading samtools moving from v0.1.18 to v1.3, but now the QUAL column 
> in the VCF is always 0.
> 
> This is my command:
>       
> samtools mpileup -uvf ref.fna sample.bam
> 
> do I have to add a switch to generate qual now?
> 
> Thanks
> 
> Adam
> 
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