RE: [NMusers] quality of SE estimate by IMP method
Ethan: I have come across this problem of yours from another user. I could not resolve that one until I made an improvement in the code, which will come out in January. I recall from that experience that the SAEM result was fine, but the objective function could not be well determined because of a peculiarity of a position of a data point, which resulted in a poor fit from the MAP estimation, which IMP (On the first iteration) and IMPMAP (on all iterations) rely on to obtain the initial proposal density. That you are using LAP also suggests this. If you wish, you may send me your control stream and data set, and I can try a couple of extra things to see if it will work in nm712. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: Ethan Wu [mailto:ethan.w...@yahoo.com] Sent: Friday, September 17, 2010 9:13 AM To: Bauer, Robert; nmusers@globomaxnm.com Subject: Re: [NMusers] quality of SE estimate by IMP method Hi Bob, IMP/MAP also came back with pretty similar OBJ like IMP. Below is the code I use, am I doing the wrong way? $ESTIMATION METHOD=IMPMAP INTERACTION LAP EONLY=1 NOABORT NITER=20 PRINT=1 SIGL=6 NSIG=2 ISAMPLE=1000 Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 2:26:07 PM Subject: RE: [NMusers] quality of SE estimate by IMP method Yes. Read the METHOD=CHAIN section in the intro712.pdf manual. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com <http://www.icondevsolutions.com/> From: Ethan Wu [mailto:ethan.w...@yahoo.com] Sent: Thursday, September 16, 2010 12:19 PM To: Bauer, Robert; nmusers@globomaxnm.com Subject: Re: [NMusers] quality of SE estimate by IMP method Hi Bob, Is there a way to pick up from the last run with SAEM/IMP so to only run the additional step IMPMAP? Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 12:12:28 PM Subject: RE: [NMusers] quality of SE estimate by IMP method At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see if that helps. Let it run for 20 iterations. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com <http://www.icondevsolutions.com/> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: Thursday, September 16, 2010 11:46 AM To: nmusers@globomaxnm.com Subject: [NMusers] quality of SE estimate by IMP method Dear uses, I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I used IMP method after SAEM to generate SE estimate. In this case, at the end of SAEM iteration, OBJ was quite stable and negative several thousand. But, with IMP, after 5 iterations, Obj was up to positive several 10 to power of 7. Obj was decreasing during this 5 iterations. My questions is, dose this mean SE estimate is not reliable? Should I increase iterations of IMP? Thank you. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland R
Re: [NMusers] quality of SE estimate by IMP method
Hi Bob, IMP/MAP also came back with pretty similar OBJ like IMP. Below is the code I use, am I doing the wrong way? $ESTIMATION METHOD=IMPMAP INTERACTION LAP EONLY=1 NOABORT NITER=20 PRINT=1 SIGL=6 NSIG=2 ISAMPLE=1000 Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 2:26:07 PM Subject: RE: [NMusers] quality of SE estimate by IMP method Yes. Read the METHOD=CHAIN section in the intro712.pdf manual. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel:(215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: Ethan Wu [mailto:ethan.w...@yahoo.com] Sent: Thursday, September 16, 2010 12:19 PM To: Bauer, Robert; nmusers@globomaxnm.com Subject: Re: [NMusers] quality of SE estimate by IMP method Hi Bob, Is there a way to pick up from the last run with SAEM/IMP so to only run the additional step IMPMAP? Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 12:12:28 PM Subject: RE: [NMusers] quality of SE estimate by IMP method At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see if that helps. Let it run for 20 iterations. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel:(215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: Thursday, September 16, 2010 11:46 AM To: nmusers@globomaxnm.com Subject: [NMusers] quality of SE estimate by IMP method Dear uses, I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I used IMP method after SAEM to generate SE estimate. In this case, at the end of SAEM iteration, OBJ was quite stable and negative several thousand. But, with IMP, after 5 iterations, Obj was up to positive several 10 to power of 7. Obj was decreasing during this 5 iterations. My questions is, dose this mean SE estimate is not reliable? Should I increase iterations of IMP? Thank you. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
RE: [NMusers] quality of SE estimate by IMP method
Yes. Read the METHOD=CHAIN section in the intro712.pdf manual. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: Ethan Wu [mailto:ethan.w...@yahoo.com] Sent: Thursday, September 16, 2010 12:19 PM To: Bauer, Robert; nmusers@globomaxnm.com Subject: Re: [NMusers] quality of SE estimate by IMP method Hi Bob, Is there a way to pick up from the last run with SAEM/IMP so to only run the additional step IMPMAP? Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 12:12:28 PM Subject: RE: [NMusers] quality of SE estimate by IMP method At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see if that helps. Let it run for 20 iterations. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com <http://www.icondevsolutions.com/> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: Thursday, September 16, 2010 11:46 AM To: nmusers@globomaxnm.com Subject: [NMusers] quality of SE estimate by IMP method Dear uses, I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I used IMP method after SAEM to generate SE estimate. In this case, at the end of SAEM iteration, OBJ was quite stable and negative several thousand. But, with IMP, after 5 iterations, Obj was up to positive several 10 to power of 7. Obj was decreasing during this 5 iterations. My questions is, dose this mean SE estimate is not reliable? Should I increase iterations of IMP? Thank you. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
Re: [NMusers] quality of SE estimate by IMP method
Hi Bob, Is there a way to pick up from the last run with SAEM/IMP so to only run the additional step IMPMAP? Thank you. From: "Bauer, Robert" To: Ethan Wu ; nmusers@globomaxnm.com Sent: Thu, September 16, 2010 12:12:28 PM Subject: RE: [NMusers] quality of SE estimate by IMP method At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see if that helps. Let it run for 20 iterations. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel:(215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: Thursday, September 16, 2010 11:46 AM To: nmusers@globomaxnm.com Subject: [NMusers] quality of SE estimate by IMP method Dear uses, I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I used IMP method after SAEM to generate SE estimate. In this case, at the end of SAEM iteration, OBJ was quite stable and negative several thousand. But, with IMP, after 5 iterations, Obj was up to positive several 10 to power of 7. Obj was decreasing during this 5 iterations. My questions is, dose this mean SE estimate is not reliable? Should I increase iterations of IMP? Thank you. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
RE: [NMusers] quality of SE estimate by IMP method
At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see if that helps. Let it run for 20 iterations. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: Thursday, September 16, 2010 11:46 AM To: nmusers@globomaxnm.com Subject: [NMusers] quality of SE estimate by IMP method Dear uses, I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I used IMP method after SAEM to generate SE estimate. In this case, at the end of SAEM iteration, OBJ was quite stable and negative several thousand. But, with IMP, after 5 iterations, Obj was up to positive several 10 to power of 7. Obj was decreasing during this 5 iterations. My questions is, dose this mean SE estimate is not reliable? Should I increase iterations of IMP? Thank you. ICON plc made the following annotations. -- This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
