Re: [balita-anda] Amoxycillin sebabkan meningitis...?
Rekan netters, Saya ingin tahu lebih banyak mengenai meningitis ini. Umur berapa anak siap di suntik imun meningitis ini ? Apakah ada efek samping dari imunisasi tsb ? Terima kasih Imelda Pasni wrote: Aseptic meningitis after treatment with amoxicillin W Czerwenka, C Gruenwald, D Conen. Department of Internal Medicine, Canton Hospital, CH-5001 Aarau, Switzerland The development of aseptic meningitis has been associated with various drugsfor example, non-steroidalanti-inflammatory drugs, ranitidine, carbamazepine, vaccines against hepatitis B and mumps, immunoglobulins, co-trimoxazole,and penicillin.1-5 We report a case of aseptic meningitis after treatment with amoxicillin. A 76 year old woman was admitted to our hospital with fever, headache, and neck stiffness. Five days before admission shehad had a pretibial wound treated with amoxicillin-clavulanic acid. Long term treatment with aspirin, enalapril, and levothyroxine(thyroxine) had not been changed in the previous month. Two days before admission she had developed fever, headache, andneck ache. On admission her general condition was poor, but findings on physical examination were normal except for neck stiffness. Alllaboratory findings were within the normal range. Cerebrospinal fluid showed pleocytosis with 63 cells (62 monocytes) and aslightly raised protein concentration of 0.47 g/l (0.15-0.45 g/l). No micro-organisms were found. She recovered with treatment of symptoms. >From her history we knew of two similar episodes in 1992 and 1995. Twelve and 6 days respectively after the initiation ofantibiotic treatment with amoxicillin (with and without clavulanic acid), she had been admitted to our hospital with the same symptoms of fever, headache, and neck stiffness. Cerebrospinal fluid had been examined during the first admission and also showed pleocytosis with 40 cells (38 monocytes) without an increase in protein concentration. No bacterial micro-organisms or serological signs of neurotropic viral infections had been found. On the basis of these three confirmed episodes of meningitis after recurrent exposure to amoxicillin, with and without clavulanic acid, with repetitive negative testing for viral, bacterial, and mycobacterial micro-organisms, we diagnosed aseptic meningitis induced by amoxicillin. To our knowledge, this is the first well documented publication of such a severe side effect of a commonly used antibiotic. The exact mechanism for the development of aseptic meningitis induced by drugs is not known, although hypersensitivity reactions and immunological mechanisms have been suggested.5 References 1. Weksler BB, Lehany AM. Naproxen-induced recurrent aseptic meningitis. Drug Intelligence and Clinical Pharmacy 1991; 25: 1183-1184. 2. Dang CT, Riley DK. Aseptic meningitis secondary to carbamazepine therapy. Clin Infect Dis 1996; 22: 729-730[Medline]. 3. Durand JM, Suchet L. Ranitidine and aseptic meningitis. BMJ 1996; 312: 886. 4. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med 1994; 121: 259-262[Medline]. 5. River Y, Averbuch-Heller L, Weinberger M, Meiner Z, Mevorach D, Schlesinger I, et al. Antiobiotic induced meningitis. J Neurol Neurosurg Psychiatry 1994; 57: 705-708[Abstract]. British Medical Journal 1999 A second case of recurrent aseptic meningitis due to amoxicillin Tony Reiman, Assistant Chief Medical Resident , Dalhousie Uinversity eBMJ, 5 Jun 1999 [Response] A second case of recurrent aseptic meningitis due to amoxicillin I recently admitted a 50 year old woman to the hospital with a 12 hour history of fever, headache, nausea/vomiting and conjunctival injection. She had recently been diagnosed with mitral regurgitation, and had been to the dentist that morning. She had taken oral amoxicillin prior to her dental cleaning as prophylaxis against endocarditis. Lumbar puncture on the night of admission revealed a white blood cell count of over 600 white cells per high power field, predominantly neutrophils, with a normal glucose level and a protein level twice the upper limit of normal. Gram's stain and culture of the CSF were negative, although the patient was initially treated with antibiotics because of the high CSF neutrophil count. A repeat lumbar puncture several days later revealed a modest pleocytosis with a predominance of monocytes. This patient had two previous episodes of a similar nature. Two years previously, she had been admitted with aseptic meningitis that followed the administration of amoxicillin for an upper respiratory tract infection. One year prior to that, she had been diagnosed with a serum sickness related to oral cefuroxime; in retrospect, it was clear that she had received amoxicillin before developing this illness as well. The patient was discharged home in good condition after bacterial meningitis had been ruled out.
Re: [balita-anda] Amoxycillin sebabkan meningitis...?
Mbak, imunisasi untuk meningitis namanya HIB, sebaiknya pada usia 2 bulan bayi sudah diberikan imunisasi HIB yang pertama. Keterangan lengkap mengenai imunisasi ini bisa mbak liat di homepage : www.dokteranak.or.id Di situ lengkap keterangan mengenai jadwal berbagai imunisasi sampai anak usia 2 tahun. Kalo efek samping badan jadi panas seperti pada DPT, pada HIB tidak. Efek samping lainnya rasanya tidak ada ya...sama saja seperti imunisasi lainnya. Semoga keterangan ini bermanfaat. salam mama jonathan On Tue, 14 Dec 1999 15:03:38 Lily Trisna Dewi wrote: Rekan netters, Saya ingin tahu lebih banyak mengenai meningitis ini. Umur berapa anak siap di suntik imun meningitis ini ? Apakah ada efek samping dari imunisasi tsb ? Terima kasih Imelda Pasni wrote: Aseptic meningitis after treatment with amoxicillin W Czerwenka, C Gruenwald, D Conen. Department of Internal Medicine, Canton Hospital, CH-5001 Aarau, Switzerland The development of aseptic meningitis has been associated with various drugsfor example, non-steroidalanti-inflammatory drugs, ranitidine, carbamazepine, vaccines against hepatitis B and mumps, immunoglobulins, co-trimoxazole,and penicillin.1-5 We report a case of aseptic meningitis after treatment with amoxicillin. A 76 year old woman was admitted to our hospital with fever, headache, and neck stiffness. Five days before admission shehad had a pretibial wound treated with amoxicillin-clavulanic acid. Long term treatment with aspirin, enalapril, and levothyroxine(thyroxine) had not been changed in the previous month. Two days before admission she had developed fever, headache, andneck ache. On admission her general condition was poor, but findings on physical examination were normal except for neck stiffness. Alllaboratory findings were within the normal range. Cerebrospinal fluid showed pleocytosis with 63 cells (62 monocytes) and aslightly raised protein concentration of 0.47 g/l (0.15-0.45 g/l). No micro-organisms were found. She recovered with treatment of symptoms. From her history we knew of two similar episodes in 1992 and 1995. Twelve and 6 days respectively after the initiation ofantibiotic treatment with amoxicillin (with and without clavulanic acid), she had been admitted to our hospital with the same symptoms of fever, headache, and neck stiffness. Cerebrospinal fluid had been examined during the first admission and also showed pleocytosis with 40 cells (38 monocytes) without an increase in protein concentration. No bacterial micro-organisms or serological signs of neurotropic viral infections had been found. On the basis of these three confirmed episodes of meningitis after recurrent exposure to amoxicillin, with and without clavulanic acid, with repetitive negative testing for viral, bacterial, and mycobacterial micro-organisms, we diagnosed aseptic meningitis induced by amoxicillin. To our knowledge, this is the first well documented publication of such a severe side effect of a commonly used antibiotic. The exact mechanism for the development of aseptic meningitis induced by drugs is not known, although hypersensitivity reactions and immunological mechanisms have been suggested.5 References 1. Weksler BB, Lehany AM. Naproxen-induced recurrent aseptic meningitis. Drug Intelligence and Clinical Pharmacy 1991; 25: 1183-1184. 2. Dang CT, Riley DK. Aseptic meningitis secondary to carbamazepine therapy. Clin Infect Dis 1996; 22: 729-730[Medline]. 3. Durand JM, Suchet L. Ranitidine and aseptic meningitis. BMJ 1996; 312: 886. 4. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med 1994; 121: 259-262[Medline]. 5. River Y, Averbuch-Heller L, Weinberger M, Meiner Z, Mevorach D, Schlesinger I, et al. Antiobiotic induced meningitis. J Neurol Neurosurg Psychiatry 1994; 57: 705-708[Abstract]. ) British Medical Journal 1999 A second case of recurrent aseptic meningitis due to amoxicillin Tony Reiman, Assistant Chief Medical Resident , Dalhousie Uinversity eBMJ, 5 Jun 1999 [Response] A second case of recurrent aseptic meningitis due to amoxicillin I recently admitted a 50 year old woman to the hospital with a 12 hour history of fever, headache, nausea/vomiting and conjunctival injection. She had recently been diagnosed with mitral regurgitation, and had been to the dentist that morning. She had taken oral amoxicillin prior to her dental cleaning as prophylaxis against endocarditis. Lumbar puncture on the night of admission revealed a white blood cell count of over 600 white cells per high power field, predominantly neutrophils, with a normal glucose level and a protein level twice the upper limit of normal. Gram's stain and culture of the CSF were negative, although the patient was initially treated with
Re: [balita-anda] Amoxycillin sebabkan meningitis...?[Fwd: [IDAI-OT] Re: Imunisasi]
Saya fw-kan dari mailist tetangga. -Original Message- From: endang [mailto:[EMAIL PROTECTED]] Sent: Monday, December 06, 1999 11:56 Haleluya To: [EMAIL PROTECTED] Subject: [IDAI-OT] Imunisasi Bapak Endang, Imunisasi Hib sampai saat ini masih dikategorikan "dianjurkan" oleh Ikatan Dokter Anak Indonesia; jadi bukan yang diwajibkan.Hib singkatan dari nama bakteri: Haemophillus influenzae tipe b. Kita ketahui bakteri ini dapat menimbulkan berbagai penyakit, tetapi 2 penyakit yang tersering adalah radang selaput otak (meningitis) dan radang paru (pneumonia). Umumnya sebelum usia 2 bulan bayi masih memiliki kekebalan terhadap Hib dari ibunya, sehingga belum perlu diimunisasi. Penelitian terbatas di Jakarta didapatkan kurang lebih 4 dari 10 bayi dengan meningitis ternyata sebabnya Hib, terbanyak berusia antara 6-12 bulan. Itulah sebabnya dianjurkan pemberiannya sebelum usia 6 bulan (mulai dari 2 bulan; meskipun bisa dimulai sejak 1,5 bulan). Sebelum 6 bulan diberikan 3 kali bila digunakan vaksin ActHib; atau 2 kali bila digunakan vaksin PedvaxHibB. Besarnya kemungkinan Hib sebagai penyebab pneumonia sampai sekarang belum ada data di Indonesia. Vaksin lain yang dianjurkan adalah MMR, vaksin tifoid, hepatitis A; saat ini bayi Bapak belum perlu. hanifah oswari Dok, anak saya umur 5,5 bulan, Pertanyaan saya : 1. Perlu nggak sih imunisasi HIB ini. Kalau bisa di-persen-kan, berapa persen perlunya (maksud saya kalau perlunya 75% ya akan saya imunisasikan, tapi kalau hanya 25% ya masih pikir-pikir lagi). 2. Benarkah bayi dapat diimunisasi setelah umur 2 bulan ?? Kalau tidak minimal umur berapa ?? 3. Berapa kali imunisasi HIB ini diberikan ?? 4. Imunisasi apa lagi yang dapat diberikan kepada anak saya ?? (Typus, MRR, AIDS, apa lagi ??). Kapan harus diberikan ?? Sebelumnya makasih banyak infonya. Was the salesman clueless? Productopia has the answers. http://clickhere.egroups.com/click/1702 -- Talk to your group with your own voice! -- http://www.egroups.com/VoiceChatPage?listName=idai-otm=1 Accurate impartial advice on everything from laptops to tablesaws. http://clickhere.egroups.com/click/1701 -- 20 megs of disk space in your group's Document Vault -- http://www.egroups.com/docvault/idai-ot/?m=1 Kunjungi: http://www.balita-anda.indoglobal.com "Untuk mereka yang mendambakan anak balitanya tumbuh sehat cerdas" -= Dual T3 Webhosting on Dual Pentium III 450 - www.indoglobal.com =- Etika berinternet, kirim email ke: [EMAIL PROTECTED] Berhenti berlangganan, e-mail ke: [EMAIL PROTECTED] EMERGENCY ONLY! Jika kesulitan unsubscribe, email: [EMAIL PROTECTED] http://pencarian-informasi.or.id/ - Solusi Pencarian Informasi di Internet
[balita-anda] Amoxycillin sebabkan meningitis...?
Aseptic meningitis after treatment with amoxicillin W Czerwenka, C Gruenwald, D Conen. Department of Internal Medicine, Canton Hospital, CH-5001 Aarau, Switzerland The development of aseptic meningitis has been associated with various drugsfor example, non-steroidalanti-inflammatory drugs, ranitidine, carbamazepine, vaccines against hepatitis B and mumps, immunoglobulins, co-trimoxazole,and penicillin.1-5 We report a case of aseptic meningitis after treatment with amoxicillin. A 76 year old woman was admitted to our hospital with fever, headache, and neck stiffness. Five days before admission shehad had a pretibial wound treated with amoxicillin-clavulanic acid. Long term treatment with aspirin, enalapril, and levothyroxine(thyroxine) had not been changed in the previous month. Two days before admission she had developed fever, headache, andneck ache. On admission her general condition was poor, but findings on physical examination were normal except for neck stiffness. Alllaboratory findings were within the normal range. Cerebrospinal fluid showed pleocytosis with 63 cells (62 monocytes) and aslightly raised protein concentration of 0.47 g/l (0.15-0.45 g/l). No micro-organisms were found. She recovered with treatment of symptoms. From her history we knew of two similar episodes in 1992 and 1995. Twelve and 6 days respectively after the initiation ofantibiotic treatment with amoxicillin (with and without clavulanic acid), she had been admitted to our hospital with the same symptoms of fever, headache, and neck stiffness. Cerebrospinal fluid had been examined during the first admission and also showed pleocytosis with 40 cells (38 monocytes) without an increase in protein concentration. No bacterial micro-organisms or serological signs of neurotropic viral infections had been found. On the basis of these three confirmed episodes of meningitis after recurrent exposure to amoxicillin, with and without clavulanic acid, with repetitive negative testing for viral, bacterial, and mycobacterial micro-organisms, we diagnosed aseptic meningitis induced by amoxicillin. To our knowledge, this is the first well documented publication of such a severe side effect of a commonly used antibiotic. The exact mechanism for the development of aseptic meningitis induced by drugs is not known, although hypersensitivity reactions and immunological mechanisms have been suggested.5 References 1. Weksler BB, Lehany AM. Naproxen-induced recurrent aseptic meningitis. Drug Intelligence and Clinical Pharmacy 1991; 25: 1183-1184. 2. Dang CT, Riley DK. Aseptic meningitis secondary to carbamazepine therapy. Clin Infect Dis 1996; 22: 729-730[Medline]. 3. Durand JM, Suchet L. Ranitidine and aseptic meningitis. BMJ 1996; 312: 886. 4. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med 1994; 121: 259-262[Medline]. 5. River Y, Averbuch-Heller L, Weinberger M, Meiner Z, Mevorach D, Schlesinger I, et al. Antiobiotic induced meningitis. J Neurol Neurosurg Psychiatry 1994; 57: 705-708[Abstract]. © British Medical Journal 1999 A second case of recurrent aseptic meningitis due to amoxicillin Tony Reiman, Assistant Chief Medical Resident , Dalhousie Uinversity eBMJ, 5 Jun 1999 [Response] A second case of recurrent aseptic meningitis due to amoxicillin I recently admitted a 50 year old woman to the hospital with a 12 hour history of fever, headache, nausea/vomiting and conjunctival injection. She had recently been diagnosed with mitral regurgitation, and had been to the dentist that morning. She had taken oral amoxicillin prior to her dental cleaning as prophylaxis against endocarditis. Lumbar puncture on the night of admission revealed a white blood cell count of over 600 white cells per high power field, predominantly neutrophils, with a normal glucose level and a protein level twice the upper limit of normal. Gram's stain and culture of the CSF were negative, although the patient was initially treated with antibiotics because of the high CSF neutrophil count. A repeat lumbar puncture several days later revealed a modest pleocytosis with a predominance of monocytes. This patient had two previous episodes of a similar nature. Two years previously, she had been admitted with aseptic meningitis that followed the administration of amoxicillin for an upper respiratory tract infection. One year prior to that, she had been diagnosed with a serum sickness related to oral cefuroxime; in retrospect, it was clear that she had received amoxicillin before developing this illness as well. The patient was discharged home in good condition after bacterial meningitis had been ruled out. I believe that this woman had an adverse reaction to amoxicillin, just as your patient did. One of our junior residents performed a computer search for other cases of amoxicillin-induced meningitis, and tells me that one other case in Sweden
