RE: Age Question/Longevity & Histio
I had some ISP problems, I'm playing catch-up here, forgive me if things have already been answered. Dr. Padgett and a group studied several types of cancer, and were able to conclude at that time that only histio and mast cell definitely had a hereditary basis in the breed. He is studying hemangiosarcoma and one other type of cancer at the present time, and he is not yet ready to make any hard and fast conclusions. Pat Long (& Luther) Berwyn PA
RE: Age Question/Longevity & Histio
>SOMETHING takes a sizeable number of our dogs young. Bloat. 11 deaths, average age 60 months. There are a lot of non-specified cancers where no definitive diagnosis was ever made or determined, there were 47 cancer deaths ranging in age from 18 months to 84 months, all below the average age of death. Some were specified, others were just "liver cancer", or just "cancer". So cancer is definitely lowering the lifespan. I'll try to work up some stats by category. Pat
Re: Age Question/Longevity & Histio
I was told the same thing when I personally was diagnosed with lymphoma. Molly Charlottesville, VA T Thompson wrote: > Hi Ruth and All, > > Dr. Padgett addressed lymphoma at the Swiss Health Symposium. He stated > that he has studied the pedigrees and offspring of 80 affected dogs but > did not find that it was an inherited cancer in Bernese. Additionally, he > stated that he thinks lymphoma is caused by a virus. > > terry thompson > missoula, montana
Re: Age Question/Longevity & Histio
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Re: Age Question/Longevity & Histio
> > ** yes, that is what he has concluded so far. however, he also said at the > Symposium that he suspects hemangiosarcoma as being inherited, but does not > yet have sufficient information ***I like the "so far" part. That's why I do not consider any study about heritability of cancers to exclude it as a factor. All a study can really claim is that the evidence gathered does not support heritibility or does support it. Dog research of this type is not generally ultimately conclusive. Remember where Padgett's info comes from. It's like our health survey. Complete? No. Best we have? Yes. ***Hemangiosarcoma would be top on my list of cancers that occur in Bernese that are not known to be hereditary which have greatest liklihood of being hereditary. ***Padgett thinks lymphoma may be virally induced. Others think it may be induced by poisons. I suspect we live in a very viral, polluted environment and that it will be a very long time before we have the answers to these questions. Ruth Ryenolds
Re: Age Question/Longevity & Histio
> Ruth excuse my ignorance, but wasn't the study done by Dr. Padgett done to determine the hereditability of cancer in Bernese and wasn't it concluded that only histio and mast cell were hereditary No, you'll have to forgive MY ignorance Susan. That might have been a conclusion that was drawn by the research team. I can't say. Regardless, I do not consider that or any other study to be a definitive study to eliminate heredity as a factor in other cancers in our breed. In fact, I suspect in time we'll find out there are other cancers which are indeed hereditary in our breed. Ruth Reynolds
Fwd: Re: Age Question/Longevity & Histio
Date: Wed, 20 Nov 2002 13:39:02 -0700 To: [EMAIL PROTECTED], [EMAIL PROTECTED] From: T Thompson <[EMAIL PROTECTED]> Subject: Re: Age Question/Longevity & Histio Cc: [EMAIL PROTECTED], [EMAIL PROTECTED] Hi Susan and all, Susan wrote: Ruth excuse my ignorance, but wasn't the study done by Dr. Padgett done to determine the hereditability of cancer in Bernese and wasn't it concluded that only histio and mast cell were hereditary? ** yes, that is what he has concluded so far. however, he also said at the Symposium that he suspects hemangiosarcoma as being inherited, but does not yet have sufficient information terry thompson missoula, montana
Re: Age Question/Longevity & Histio
Hi Susan and all, Susan wrote: Ruth excuse my ignorance, but wasn't the study done by Dr. Padgett done to determine the hereditability of cancer in Bernese and wasn't it concluded that only histio and mast cell were hereditary? ** yes, that is what he has concluded so far. however, he also said at the Symposium that he suspects hemangiosarcoma as being inherited, but does not yet have sufficient information terry thompson missoula, montana
Re: Age Question/Longevity & Histio
Hi Ruth and All, Dr. Padgett addressed lymphoma at the Swiss Health Symposium. He stated that he has studied the pedigrees and offspring of 80 affected dogs but did not find that it was an inherited cancer in Bernese. Additionally, he stated that he thinks lymphoma is caused by a virus. terry thompson missoula, montana
Re: Age Question/Longevity & Histio
On Wed, 20 Nov 2002 13:50:24 -0600 "Ruth Reynolds" <[EMAIL PROTECTED]> writes: > It is my understanding that lymphoma is the most common cancer in > dogs in > general. I'm not sure if there is a heritable component to it or > not. It's > really hard to determine this when a dog dies of it and produces > the breed > average for it. I don't know that it would really be determinable > even if > the dog produced a higher than average incidence of it. But in such > a case > I'd be leaning in the direction of a heritable component to its > occurence Ruth excuse my ignorance, but wasn't the study done by Dr. Padgett done to determine the hereditability of cancer in Bernese and wasn't it concluded that only histio and mast cell were hereditary? Susan Ablon Gweebarra BMD Balch Springs, Tx http://www.pageweb.com/gwebara
Re: Age Question/Longevity & Histio
In a message dated 11/20/2002 2:41:50 PM Eastern Standard Time, [EMAIL PROTECTED] writes: > Cancer, number of dogs, average > age at time of death (in months) from the 2000 BMDCA health survey: > > Malignant histio 43 89.7 > Lymphosarcoma12 78 > Hemangiosarcoma 7 113 > Lymphoma 7 98.5 > Osteosarcoma 6 93.3 > Mast cell 5 81.7 The youngest average here is 6-1/2 yrs for lymphosarcoma... but we know we loose enough dogs young to bring the average to 7 yrs. Pat does the curve tell us anything? SOMETHING takes a sizeable number of our dogs young.. -Sherri Venditti
Re: Age Question/Longevity & Histio
>> The cancer that really hurts us is lymphoma. It is my understanding that lymphoma is the most common cancer in dogs in general. I'm not sure if there is a heritable component to it or not. It's really hard to determine this when a dog dies of it and produces the breed average for it. I don't know that it would really be determinable even if the dog produced a higher than average incidence of it. But in such a case I'd be leaning in the direction of a heritable component to its occurence. Ruth Reynolds
Re: Age Question/Longevity & Histio
Valerie, I think you'll be very surprised! The average age at time of death for histio was 89.7 months, and the overall average was 84.43 months. So if we remove histio as part of the average age calculation, the average age at time of death - would go down! But if we find a way to prevent histio, then those dogs would live even longer, thereby increasing the average lifespan. The cancer that really hurts us is lymphoma. Cancer, number of dogs, average age at time of death (in months) from the 2000 BMDCA health survey: Malignant histio 43 89.7 Lymphosarcoma 12 78 Hemangiosarcoma 7 113 Lymphoma 7 98.5 Osteosarcoma 6 93.3 Mast cell 5 81.7 Pat Long (& Luther) Berwyn PA _ Add photos to your messages with MSN 8. Get 2 months FREE*. http://join.msn.com/?page=features/featuredemail
Age Question/Longevity & Histio
My heart just breaks to see the roll call of histio victims - and I know there are many more to come. Many of the names are familiar to me only through this list, some I have known personally. I was just wondering, if about 1 in 6 berners dies from histio, and if we took the histio deaths out of the longevity statistics, I wonder what the average age would be then? That figure may make the importance of the histio genetic study a little more obvious. Valerie
