Dear CCP4ers,
a PostDoctoral position is immediately available in Alessandro Vannini's lab at
the Institute of Cancer Research in central London to structurally and
functionally characterise large multi-subunit complexes involved in eukaryotic
transcription (www.icr.ac.uk/alessandrovannini).
We are looking for highly motivated and creative individuals with a strong
interest in structural characterization of multi-subunit complexes. We
currently employ single particle electron microscopy analysis and x-ray
crystallography, as well as biochemical and biochemical analysis, to elucidate
the role of the RNA Polymerase III transcription apparatus in cancer and other
fundamental cellular processes (www.icr.ac.uk/alessandrovannini).
The lab is well equipped with a fleet of AKTAs (including a brand new AKTA
Pure) and have access to divisional managed facilities for protein
crystallography (Bruker Microstar and CCD detector and crystallisation robots),
cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with
expertise in multi-subunit expression (insect cell, yeast and bacterial
expression, including a 60 L fermentor). The Division is also well equipped
with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle
light scattering).
Applicants should possess a PhD (or equivalent) in biochemistry or molecular
biology with a sound knowledge of multi-subunit complex production and
purification. Experience in purification of recombinant and/or endogenous
proteins for structural biology analysis is essential for this post. Experience
in protein crystallography and/or single particle electron microscopy would be
desirable. Individuals with a strong background in biochemical characterization
of transcription machineries wishing to learn structural biology techniques
will be taken into serious consideration.
The lab is located in the heart of central London, in the vibrant area of South
Kensington.
Appointment will be on Fixed Term Contract for 2 years in the first instance,
with a starting salary in the range of £28,087 to £34,529 p.a. inclusive (based
on previous post-doctoral experience).
CV and cover letter must be submitted online at http://www.icr.ac.uk/jobsearch
Informal enquiries can be sent directly to alessandro.vann...@.icr.ac.uk
Job Ref. No. 1355633
Closing Date: 15/09/2013
Cheerio,
Ale
