[ccp4bb] Off-topic: 3D display (VG278HR) + graphics card (Quadro K600) available

[Matic Kisovec]

Dear all,

in case anybody is looking for a used but solid 3D capable display together 
with Nvidia glasses and a suitable graphics card you can contact me.
We have a 27" ASUS 
VG278HR + Pny Quadro 
K600
 setup in a working condition and would like to give it a new home. We are very 
happy with the system but it has only been used sporadically and even less in 
the last year.
The combination has been discussed multiple times on CCP4BB and is compatible 
with more or less every crystallographic software.

The items are located in Slovenia, EU.

Kind regards,
Matic


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[ccp4bb] Two postdoctoral positions available at Duke-NUS Singapore working on cryoEM

[Sheemei Lok]

Crystallography or cryoEM post-doctoralpositions are available at the Duke-NUS 
Graduate Medical School, Singapore. Duke-NUSGraduate Medical School is a global 
partnership between Duke University in theUS and the National University of 
Singapore. Two post-doctoral positions with competitive salary packages are 
availableat the laboratory of Shee-Mei Lok (http://www.loksheemeilab.com/) in 
theEmerging Infectious Disease program of the Duke-NUS.  Projects undertaken by 
the post-doc will leadto further understanding of the neutralization mechanism 
of various antiviraltherapeutics against flavivirus viruses. Individuals with 
experience in x-ray crystallographyand/or cryoEM image reconstruction are 
highly desirable.Interested individuals should send their CV,experience, 
research interest, and a list of three referees to Dr Shee-mei Lok atthis 
email: sheemei@duke-nus.edu.sg.  

  
  

[ccp4bb] Crystallisation Laboratory Manager (Senior Support Scientist) - VMXi beamline

[Thomas Sorensen]

Dear All

A position to join the VMXi team at Diamond Light Source as Crystallisation 
Laboratory Manager is available (Closing date is March 5th)

The VMXi team is looking to recruit a crystallisation laboratory manager who 
will be part of the beamline team and be responsible for managing 
crystallisation facilities at Diamond and the Research Complex at Harwell. The 
position at the newly commissioned VMXi beamline - dedicated to in situ 
diffraction - will provide the opportunity to develop new workflows and 
methodologies with the VMXi team as well as provide state of the art facilities 
for crystallisation of soluble and membrane proteins. The post holder will be 
responsible for operations and development of crystallisation facilities at 
Diamond.  The post holder will provide both scientific and technical support to 
the large user base - catering for both on-site and remote users.

Details of the post can be found 
here

(or use the link http://www.diamond.ac.uk/Careers/Vacancies/All/0013_17_CH.html)

Feel free to contact me for further information

Best wishes

Thomas :-)

==
Prof. Thomas Sorensen
Principal Beamline Scientist VMXi
Diamond Light Source


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[ccp4bb] PhD Studentship in Meiotic Chromosome Structure

[Owen Davies]

Dear colleagues,

I would like to advertise a PhD studentship that is available in my lab to 
study the molecular structure of meiotic chromosomes through biochemistry and 
structural biology. The details of the project are as follows:

PhD studentship in Biochemistry and Structural Biology - The Molecular 
Structure of Meiotic Chromosomes
The reduction in chromosome number during meiosis is essential for the 
production of haploid germ cells that produce healthy offspring upon 
fertilisation. This is achieved through an elaborate cellular process of 
chromosome 'choreography' during meiotic prophase, in which errors lead to 
infertility, miscarriage and genetic disorders such as Down's syndrome. Rapid 
chromosomal movements enable the identification and synapsis of homologous 
chromosome pairs. Once achieved, homologues exchange genetic material through 
crossing over and are then moved into position at metaphase to enable their 
correct segregation into haploid cells. This intricate process depends upon 
chromosome telomeric ends being tethered to the nuclear envelope by the 
meiotic-telomere complex (MAJIN, TERB1, TERB2, TRF1) and connected to the 
cytoskeleton by the LINC complex (SUN1, KASH5). However, whilst essential for 
meiosis, we currently lack essential molecular understanding regarding their 
structure and function.

This PhD project aims to elucidate the molecular structure of the 
meiotic-telomere and LINC complexes, and their mechanisms of interaction with 
telomeres and the cytoskeleton. It will involve recombinant protein 
purification, biochemistry, biophysics (including SEC-MALS, SEC-SAXS, CD and 
EM) and X-ray crystallography. This project is part of an international 
collaboration with EM tomography, genetics and cellular biology groups, and 
will likely result in high impact research findings in the fields of cell 
division and chromosomal biology. The successful candidate will be a 
highly-motivated individual with interests in solving fundamental molecular 
questions of cellular function through structural biology.

Funding details
Each award is worth £18,500 per year, paying the UK/EU PhD tuition fees and 
providing annual living expenses of £14,057. Total value of each award is 
£74,000.

Eligibility Criteria
You must have, or expect to achieve, at least a 2:1 Honours degree or 
international equivalent in biochemistry or a related area. A further 
qualification such as an MSc or MRes is advantageous.

This award is available to UK/EU and international applicants; the studentship 
pays fees at the UK/EU level so international candidates would be liable for 
the additional international fees. If English is not your first language, you 
must have IELTS 7 with at least 6.5 in the written component, or equivalent.

Start date and duration
September 2017 for a three year PhD.

Application closing date
5th April 2017

Advert website
http://www.jobs.ac.uk/job/AXO859/phd-studentship-in-biochemistry-and-structural-biology-the-molecular-structure-of-meiotic-chromosomes/

How to apply
You must apply through the University's online postgraduate application system. 
To do this please 'Create a new 
account'.  Only mandatory fields need 
to be completed. However, you will need to include the following information:

  *   insert the programme code 8300F in the programme of study section
  *   select 'PhD in the Faculty of Medical Sciences - Cell and Molecular 
Biosciences' as the programme of study
  *   insert the studentship code CB131 in the studentship/partnership 
reference field
  *   attach a covering letter and CV. The covering letter must state the title 
of the studentship, quote the studentship reference code CB131 and state how 
your interests and experience relate to the project
  *   attach degree transcripts and certificates and, if English is not your 
first language, a copy of your English language qualifications.

Please also feel free to contact me directly with any further queries.

Best wishes,

Owen Davies.

Dr Owen Davies
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences
Newcastle University
United Kingdom

Telephone: +44 (0)191 208 7371
e-mail: owen.dav...@newcastle.ac.uk
website: http://www.ncl.ac.uk/camb/staff/profile/owen.davies