Assuming that there are no bad van der Waals contacts, there should not be a
problem. All the hydrophilic residues in your loop have hydrophobic parts which
the methionine can interact with favourably. This should send any nearby waters
into the more disordered bulk phase, which is entropically favourable, if you
believe the traditional hydrophobic effect theory (although there was never
much evidence for it, afaik). For your loop, it's more a question of whether
the charged groups have sufficient solvent accessibility or can interact with
each other enough for the conformation to be stable. Hope this helps a bit.
Best wishes, Jon Cooper. jon.b.coo...@protonmail.com
Original Message
On 25 Oct 2020, 20:54, amit gaur wrote:
> Hi All,
> I have a question that, I have a loop region with hydrophilic
> residues(TNETRERE) that lie close to methionine. Can, repulsive forces may
> occur because between methionine and hydrophilic residues?
>
> --
>
> Dr. Amit Gaur
> Post Doctoral Researcher
> Thomas Jefferson University
>
> ---
>
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