[ccp4bb] UMMS Postdoctoral Job Posting - Korostelev Lab

2020-11-09 Thread Powers, Ann 
Good afternoon,

Please take note of the below postdoctoral job posting opportunity.   Best 
regards, Ann Powers on behalf of Andrei Korostelev, Ph.D.

Postdoctoral position in cryo-EM and translation regulation ‒ from bacteria to 
neurons
Korostelev Lab, University of Massachusetts Medical School
We study how the ribosome interacts with numerous cellular components to 
achieve high accuracy and efficiency of gene expression. We’d like to 
understand the key roles of translation and ribosomes in: (1) Neurodevelopment 
and neurodegenerative diseases; (2) Bacterial stress signaling and gene 
regulation (e.g. coupling with transcription); and other aspects of gene 
expression (https://www.umassmed.edu/korostelev-lab/). We use a range of 
approaches, including cryo-EM and biochemistry (see selected references below).
Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and 
highly interactive research community: 
https://www.umassmed.edu/rti/about-the-rti/faculty-members/.  Our colleagues 
are interested in nearly all aspects of RNA biology, from small to large RNAs 
to RNA chemistry and therapeutics development.
We seek a highly motivated person who very recently received a PhD, or will 
soon receive a PhD.  Applications sent prior to the dissertation defense date 
are welcome.
If you are interested in using single-particle cryo-EM and in situ (cellular) 
EM to elucidate cellular mechanisms, submit the following information to 
ann.pow...@umassmed.edu:
1)  Your CV (including your publication list);
2)  Cover letter (less than 2 pages) describing:
 (i) your previous work - focusing on your most interesting finding(s),
 (ii) your scientific interests,
 (iii) which aspects of translation regulation are of interest to you.
3)  Email addresses of three references.
Selected publications (accessible via the provided links):
•Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. “ArfB 
can displace mRNA to rescue stalled 
ribosomes”. Nature Commun. 
2020.
•Loveland AB, Demo G, Korostelev AA. “Cryo-EM of elongating ribosome 
with EF-Tu GTP elucidates tRNA 
proofreading”. Nature. 2020.
•Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, 
Korostelev AA. “Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and 
poly-GR proteins revealed by 
cryo-EM”.
 bioRxiv. 2020.
•Susorov D, Egri S, Korostelev AA. "Termi-Luc: a versatile assay to 
monitor full-protein release from 
ribosomes”.
 RNA. 2020.
•Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. “Extensive 
ribosome and RF2 rearrangements during translation 
termination”. eLife. 2019.
•Loveland AB, Demo G, Grigorieff N, Korostelev AA. “Ensemble cryo-EM 
elucidates the mechanism of translation 
fidelity”.
 Nature. 2017.
•Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, 
Grigorieff N, Nudler E, Korostelev AA. “Structure of RNA polymerase bound to 
ribosomal 30S subunit”. eLife. 2017.
•Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. “Ensemble 
cryo-EM uncovers inchworm-like translocation of a viral IRES through the 
ribosome”. eLife. 2016.
•Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, 
Korostelev AA. “Ribosome•RelA structures reveal the mechanism of stringent 
response activation”. eLife. 2016
https://twitter.com/korostelevlab


Best regards,

 Ann Powers
 Administrative Coordinator for Dr. Andrei Korostelev
  [mass_rna-intitute_logo]
 University of Massachusetts Medical School
 368 Plantation Street, AS4-1046B
 Worcester, MA 01605
 774 455 4205
 ann.pow...@umassmed.edu






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[ccp4bb] UMMS Postdoctoral Associate Job Posting - Korostelev Lab RNA Therapeutics Institute

2020-11-09 Thread Ann Powers 
Postdoctoral position in cryo-EM and translation regulation ‒ from bacteria to 
neurons

Korostelev Lab, University of Massachusetts Medical School

We study how the ribosome interacts with numerous cellular components to 
achieve high accuracy and efficiency of gene expression. We’d like to 
understand the key roles of translation and ribosomes in: (1) Neurodevelopment 
and neurodegenerative diseases; (2) Bacterial stress signaling and gene 
regulation (e.g. coupling with transcription); and other aspects of gene 
expression (https://www.umassmed.edu/korostelev-lab/). We use a range of 
approaches, including cryo-EM and biochemistry (see selected references below).
Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and 
highly interactive research community: 
https://www.umassmed.edu/rti/about-the-rti/faculty-members/.  Our colleagues 
are interested in nearly all aspects of RNA biology, from small to large RNAs 
to RNA chemistry and therapeutics development.

We seek a highly motivated person who very recently received a PhD, or will 
soon receive a PhD.  Applications sent prior to the dissertation defense date 
are welcome.

If you are interested in using single-particle cryo-EM and in situ (cellular) 
EM to elucidate cellular mechanisms, submit the following information to 
ann.pow...@umassmed.edu:
1)  Your CV (including your publication list);
2)  Cover letter (less than 2 pages) describing: 
 (i) your previous work - focusing on your most interesting finding(s),
 (ii) your scientific interests, 
 (iii) which aspects of translation regulation are of interest to you.
3)  Email addresses of three references.

Selected publications (accessible via the provided links):
•   Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. “ArfB 
can displace mRNA to rescue stalled ribosomes”. Nature Commun. 2020.
•   Loveland AB, Demo G, Korostelev AA. “Cryo-EM of elongating ribosome 
with EF-Tu GTP elucidates tRNA proofreading”. Nature. 2020.
•   Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, 
Korostelev AA. “Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and 
poly-GR proteins revealed by cryo-EM”. bioRxiv. 2020.
•   Susorov D, Egri S, Korostelev AA. "Termi-Luc: a versatile assay to 
monitor full-protein release from ribosomes”. RNA. 2020.
•   Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. “Extensive 
ribosome and RF2 rearrangements during translation termination”. eLife. 2019.
•   Loveland AB, Demo G, Grigorieff N, Korostelev AA. “Ensemble cryo-EM 
elucidates the mechanism of translation fidelity”. Nature. 2017.
•   Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, 
Grigorieff N, Nudler E, Korostelev AA. “Structure of RNA polymerase bound to 
ribosomal 30S subunit”. eLife. 2017.
•   Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. “Ensemble 
cryo-EM uncovers inchworm-like translocation of a viral IRES through the 
ribosome”. eLife. 2016.
•   Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, 
Korostelev AA. “Ribosome•RelA structures reveal the mechanism of stringent 
response activation”. eLife. 2016.

https://twitter.com/korostelevlab



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[ccp4bb] Postdoc opportunities in Mobile, Alabama

2020-11-09 Thread Davies, Christopher 
My lab will soon be moving to the University of South Alabama in Mobile and I'm 
looking to recruit two post docs. One project is structural and functional 
investigations of mutated forms of penicillin-binding protein 2 (PBP2) from N. 
gonorrhoeae, with the goal of understanding molecular mechanisms underlying 
resistance to cephalosporin antibiotics. The other is drug discovery against 
PBP2 in collaboration with a pharma.

Both projects entail cloning, purification and crystallization of PBP2 
variants, collecting diffraction data at synchrotron facilities, solving 
structures by X-ray crystallography, site-directed mutagenesis, enzyme kinetics 
and various biophysical techniques.

Candidates should hold a PhD in biochemistry or chemistry, with a strong 
background in molecular biology, protein crystallography, and preferably enzyme 
kinetics. An interest in antibiotic resistance and antimicrobial drug discovery 
is desirable. The candidate will be highly motivated to succeed, able to think 
critically, and work both independently and collaboratively. Good verbal and 
written communication skills are essential.

The University of South Alabama is a comprehensive research and teaching 
university located in Mobile, Alabama. Its College of Medicine has 270 faculty 
members across 17 academic departments, with outstanding cores and facilities 
for research, including a BSL-3 facility for infectious disease research. 
Mobile (pronounced moh-BEEL) is near the Gulf Coast with ready access to 
beaches, is only two hours from New Orleans, and is one of most arboreal towns 
I've seen.

Please send cover letter and CV directly to me - Christopher Davies 
(dav...@musc.edu)
Informal enquiries are welcome.

https://gradfacultyresearch.musc.edu/#/davies

*
Christopher Davies, PhD
Professor, Dept. of Biochemistry & Molecular Biology,
Interim Chair, Department of Oral Health Sciences,
Assistant Provost for Research Infrastructure,
MUSC Cores Director,
Medical University of South Carolina,
Charleston SC 29425
Tel:  (843) 876 2302




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[ccp4bb] Job advert - Principal Investigator - Integral Membrane Proteins, University of Oxford

2020-11-09 Thread Alex Bullock 
I hope this will PI job posting might interest some of you...

A Principal Investigator post is available at the University of Oxford to lead 
an existing medium-sized research group participating in the EU IMI2 EUbOpen 
and ReSOLUTE consortia. The group is focused on the structure determination of 
human integral membrane proteins, particularly Solute Carrier (SLC) proteins, 
by X-ray crystallography and/or cryo-EM, as well as the development of binders, 
including small molecule chemical inhibitors/agonists and 
antibodies/nanobodies. Applicants should have relevant technical expertise and 
experience of managing staff. The successful candidate will benefit from a 
large portfolio of expression constructs, structural projects and assays 
already developed by the team. The post is funded to 30 April 2025 in the first 
instance.

Host institution:
https://www.cmd.ox.ac.uk/team

Advert link:
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10_internal_external=E_display_in_irish=N_process_type=_applicant_no=_form_profile_detail=_display_apply_ind=Y_refresh_search=Y_recruitment_id=148147

Kind regards

Alex




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[ccp4bb] Job Opening: Principal Beamline Scientist for HeXI - dedicated electron diffraction beamline

2020-11-09 Thread Evans, Gwyndaf (DLSLtd,RAL,LSCI) 
Dear All,

I would like to draw your attention to the following job opening at Diamond 
Light Source for the lead scientist on the development and construction of a 
new dedicated beamline for electron diffraction of biological samples.

https://vacancies.diamond.ac.uk/vacancy/hexi-electron-diffraction-principal-beamline-scientist-425143.html

If you are interested in applying and have questions about the role, please 
contact me at gwyndaf.ev...@diamond.ac.uk

Regards,
Gwyndaf


Dr Gwyndaf Evans

Deputy Director for Life Sciences - Diamond Light Source
Head of Technology - Rosalind Franklin Institute



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[ccp4bb] PDBe API webinar materials now available online

2020-11-09 Thread John Berrisford 
Dear colleagues,

 

We have recently concluded our 6-part PDBe API webinar series and are
delighted to announce that all the videos and materials associated with the
series are now freely available online.

 

To access these materials, please visit

https://pdbeurope.github.io/api-webinars. 

 

This webinar series covered PDBe's programmatic access options, from basic
data retrieval and search using the PDBe API to more advanced features,
including access and reuse of PDBe data visualisation components.

 

If you are a user of the PDBe API, then we encourage you to subscribe to our
PDBe API user mailing list, where we announce API releases, changes and
planned maintenance. To do so, please send an e-mail to
 pdbe-api-users-j...@ebi.ac.uk.

 

You can find all of PDBe's online tutorials and webinars at the
 PDBe training pages.

 

Kind regards,

 

John

 

--

John Berrisford

PDBe

European Bioinformatics Institute (EMBL-EBI)

European Molecular Biology Laboratory

Wellcome Trust Genome Campus

Hinxton

Cambridge CB10 1SD UK

Tel: +44 1223 492529

 

  http://www.pdbe.org

 
http://www.facebook.com/proteindatabank

  http://twitter.com/PDBeurope

 




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