[ccp4bb] Postdoctoral position In Structural Enzymology at the University of Minnesota

[Mikael H Elias]

Dear All,

Our lab has an opening for a postdoctoral fellowship, at the University of
Minnesota, USA. The research at our lab combines structural biology,
enzymology, bioinformatics, and microbiology ( 
http://www.eliaslab.org/). The project, funded by the DOE, is a
collaborative effort to bioelectrocatalytically reduce CO2 into formate
(please see more details here
 ). The research will involve protein biochemistry, structural
biology and protein design. 

 

Environment: The lab is hosted in the BioTechnology Institute, a highly
stimulating environment, extremely multidisciplinary with extensive
opportunities to gain expertise in cutting edge methods and techniques. The
Institute belongs to the University of Minnesota, founded in 1851 (
 https://twin-cities.umn.edu/). It is one of
the largest university in the United States, and ranks amongst the most
prestigious research universities. The campus is located in the heart of the
Minneapolis-St Paul (Twin Cities) area, an enjoyable, affordable place,
extremely rich in cultural events and natural attractions. 

 

Application: 

1.  Cover letter explaining your motivation to apply for the position (1
page max.)

2.  CV, including previous research.

3.  Names and contact information for 2-3 references. Please include
your relation to them.

The duration of the fellowship is 2 years. Deadline for application is 31st
july 2021. Starting date: as soon as possible. Please send applications to (
 mhel...@umn.edu) with subject header (Postdoc
position).

The University of Minnesota is an equal opportunity educator and employer.



 

Dr Mikael H. ELIAS

Associate Professor  |   Lab Page

Director of Undergraduate Studies (BMBB) 

University of Minnesota |  
umn.edu

Biochemistry, Molecular Biology & Biophysics Dpt

BioTechnology Institute | 1479 Gortner Ave. St. Paul, MN 55108-USA

  mhel...@umn.edu |   612-626-1915

 




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[ccp4bb] Postdoctoral position at UT Health San Antonio Texas

[Yogesh Gupta]

The laboratory of Dr. Yogesh Gupta (http://ccri.uthscsa.edu/YGupta.html) at
the University of Texas Health at San Antonio (UTHSA) is seeking an
enthusiastic Postdoctoral Fellow to study structures and function of RNA
modification and chromatin remodeling complexes. We use structural biology
(X-ray, NMR, cryo-EM) and cell-based methods to address basic mechanistic
questions in viral pathogenesis and pediatric cancers.


Further details of our most recent work can be found here:

1. Nature Communications. 2021 Jun 2; 12: 3287. PMID: 34078893. doi:
10.1038/s41467-021-23594-y


2. Nature Communications. 2020 Jul 24;11(1):3718. PMID: 32709886. doi:
10.1038/s41467-020-17496-8


Preference will be given to applicants with demonstrated experience in
purification and characterization of protein-nucleic acid complexes by
X-ray crystallography and strong interest in learning cryo-EM. Candidates
are expected to possess strong organizational, interpersonal skills, and
ability to work independently but also effectively and collaboratively as
part of a team. An ideal candidate should hold (or soon expect to hold) a
Ph.D. or equivalent degree in a related discipline and have no more than 2
years of postdoc experience.

Our laboratory is located at Greehey Children’s Cancer Research Institute
(GCCRI) of UTHSA. The GCCRI is a unique specialized cancer research center
focusing on basic and translational research in childhood cancer and
occupies a state-of-the-art 100,000 sq. foot research facility. The GCCRI
has significant external funding, a large endowment from the state, and
links to philanthropic entities.

San Antonio is the nation’s seventh largest city and is located at the edge
of the beautiful Texas Hill County. San Antonio offers a rich,
multi-cultural community, affordable cost of living, excellent weather and
a thriving biomedical industry. There is no state income tax in Texas. All
Postdoctoral appointments are designated as security sensitive positions.
The University of Texas Health Science Center at San Antonio is an Equal
Opportunity/Affirmative Action Employer including protected veterans and
persons with disabilities. Salary is competitive and commensurate with
experience.


If interested in applying, please send a short description of your research
accomplishments and a CV with contact information of 3 references to Dr.
Yogesh Gupta (email: gup...@uthscsa.edu).


Yogesh
-- 
Yogesh Gupta, PhD
Assistant Professor of Biochemistry & Structural Biology
PI, Greehey Children's Cancer Research Institute
University of Texas Health Science Center
8403 Floyd Curl Drive, San Antonio, Texas, USA 78229
http://ccri.uthscsa.edu/YGupta.html



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Re: [ccp4bb] Hydrophobic/ vander waal forces

[Brian Shoichet]

Hi Amit,

They are related but different.  van der Waals
(dispersion-attraction/repulsion, London) forces are real forces arising
from instantaneous-induced dipoles.  Whereas in most quantitative
treatments in biophysics they have an arbitrary component (e.g., the exact
way to represent the repulsive term in a classic function is open to
debate), they do represent real forces and interactions, as classically
understood.

Hydrophobic "interactions" are not formally interactions at all, they are
preferential associations reflecting a less favorable energy in the
solvated state.  Thus there is no hydrophobic interaction between groups
and atoms, there is rather the higher free energy of the solvated state
that drives them together, reducing the free energy of the system.

Hydrophobicity is one step more complicated still, in that it reflects
changes in the heat capacity of the system (moving from a solvated -->
buried hydrophobic interface reduces the heat capacity at room temperature,
in an aqueous environment).  Indeed, the formal way to measure a
hydrophobic effect is to show that there is a substantial DCp in the
process.  This, and the behavior of water, makes the hydrophobic effect
highly temperature dependent.  A hydrophobic "driving force" at one
temperature can disappear at another temperature.

The reason hydrophobic effects and van der Waals interactions are often
conflated is that the same sort of non-polar atoms lead to both.  But of
course polar atoms also interact through van der Waals interactions.

Hope this helps.

brian

On Fri, Jul 2, 2021 at 10:50 AM amit gaur  wrote:

> Hi everyone,
>  I hope everything is going well with all of you. I want to
> know that, Are hydrophobic and vander waal forces are similar? and what is
> criteria for formation of these and interatomic distances needed to form
> these interactions between amino acids? What kinds of atoms have propensity
> to form these interactions?
>
> Thank you,
> --
> *Dr. Amit Gaur*
>
> *Research AssociateThomas Jefferson University*
> *Department of Translational medicine*
> *1020, Locust Street, Jefferson Alumni Hall*
> *Philadelphia, PA 19107*
>
>
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1
>


-- 
Brian Shoichet, Professor, UCSF
latest science from the lab:  *http://www.bkslab.org/
*



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[ccp4bb] Hydrophobic/ vander waal forces

[amit gaur]

Hi everyone,
 I hope everything is going well with all of you. I want to
know that, Are hydrophobic and vander waal forces are similar? and what is
criteria for formation of these and interatomic distances needed to form
these interactions between amino acids? What kinds of atoms have propensity
to form these interactions?

Thank you,
-- 
*Dr. Amit Gaur*

*Research AssociateThomas Jefferson University*
*Department of Translational medicine*
*1020, Locust Street, Jefferson Alumni Hall*
*Philadelphia, PA 19107*



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[ccp4bb] can't mutate nucleotides to thymine in Coot - update

[Olga Moroz]

Hi everyone,

In case somebody was interested:

Thymine mystery is solved- rather stupid of me! I was building RNA rather than 
DNA - I needed a single strand, and asked Coot to build nucleic acid into 
density, but didn’t pay attention at what it was building. Not an expert on 
nucleic acids  :) 

Paul Emsley replied to my thymine question, asking me if I was sure I was 
building DNA - thank you Paul!

However, in my defence, the option "other modelling tools > build nucleic acid" 
doesn’t ask if I’d like DNA or RNa, just builds RNA. 

Best wishes,

Olga



Dr Olga Moroz
Structural Biology Laboratory,
University of York,
YORK  YO10 5DD
UK
tel +441904328269





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Re: [ccp4bb] Principal Beamline Scientist Position at Diamond Light Source

[Hall, Dave (DLSLtd,RAL,LSCI)]

Closing date for this senior position at Diamond Light Source is fast 
approaching – please don’t miss the application deadline of 11th July if 
interested.

From: "david.h...@diamond.ac.uk" 
Date: Thursday, 10 June 2021 at 13:27
To: "ccp4bb@jiscmail.ac.uk" 
Subject: Principal Beamline Scientist Position at Diamond Light Source

Dear all

We have an opportunity for a scientist with a keen interest in beamline 
development, automation and/or structural biology to join the macromolecular 
crystallography leadership team at Diamond to guide and develop the I03 
beamline. I03 is at the forefront of cryogenic automated data collection 
developments at Diamond as well as being uniquely equipped for experiments at 
biological containment level III.

For more information on the position and to apply follow the link below:

https://vacancies.diamond.ac.uk/vacancy/principal-beamline-scientist-i03-445608.html

The closing date is Sunday 11th July.

If you are interested in applying and have questions about the role please 
contact me directly.

Best wishes

Dave Hall
--
MX Group Leader
Diamond Light Source
dls.mx


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[ccp4bb] Virtual EMBO workshop on Solution Scattering

[Clement Blanchet]

Dear all, 

We would like to draw your attention to the EMBO workshop on "Solution 
Scattering", a virtual meeting taking place starting October 25th.

Application deadline: July 15th. 

See https://meetings.embo.org/event/20-solution-scattering for more information 
and application guidelines. 
Best wishes,

Clement and Melissa



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