[ccp4bb] Postdoctoral position in drug discovery

[Harp, Joel M]

Postdoctoral position in drug discovery

 An opening is available in the drug discovery laboratory of Dr. Stephen Fesik 
for a post-doc in the field of protein x-ray crystallography.  Responsibilities 
will include protein expression and purification, and all aspects of x-ray 
crystallography including preparation of protein-inhibitor complexes, 
crystallization, home/synchrotron data collection, and structure determination. 
Additional experiences in molecular biology including construct design, 
cloning, site-directed mutagenesis, and experience with recombinant protein 
expression in eukaryotic cells are highly preferred.  The ideal candidate 
should be self-motivated and be able to communicate efficiently in a highly 
collaborative environment. Please send cv to 
jason.p...@vanderbilt.edu




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[ccp4bb] Director of MacCHESS facility

[Doletha Marian Szebenyi]

The Macromolecular Diffraction Facility of the Cornell High-Energy Synchrotron 
Source (MacCHESS)is seeking a Director. MacCHESS is a component of CHESS, a 
recently-upgraded synchrotron source serving a wide variety of researchers with 
X-ray science needs, jointly funded by NIH, NSF, and DOD, with assistance from 
New York State. MacCHESS provides a facility where scientists can use both 
established and emerging technologies to pursue the goals of the biomedical 
research community. Work performed at MacCHESS, using tools including, e.g., 
crystallography and small-angle X-ray scattering, yields important insights 
into fundamental biological processes. The MacCHESS Director will play a key 
role, alongside the MacCHESS PI and other members of the CHESS leadership team, 
in the management of the CHESS facility to promote scientific research.

The primary functions of the MacCHESS Director are (1) to ensure smooth 
operation of the facility (personnel management, budgeting, upgrades), (2) to
act as Co-PI on the NIH grant (preparing reports, renewal applications, etc.), 
and (3) to participate in collaborative scientific developments at MacCHESS.

Applicants should have a Ph.D. in a relevant field (biophysics, structural 
biology etc.), and experience managing a group of mixed personnel (scientific,
technical, administrative. Experience with managing grants (writing 
applications, preparing reports, etc.) from federal agencies is highly 
desirable. Experience at a user facility is a plus, as is expertise in methods 
related to X-ray science. Good clear communication skills are a must, including 
fluency in the English language.

Located on an Ivy League university campus in picturesque upstate New York, the 
Cornell High-Energy Synchrotron Source (CHESS) serves a world-wide user base of 
structural biologists, chemists, physicists, and engineers. MacCHESS is an 
NIH-supported National Resource providing support for structural biology at 
CHESS.

Applications should be submitted at http://academicjobsonline.org/ (posting 
#20602) and should include a cover letter, a CV, a list of publications, and a 
detailed summary of research experience and interests. Please arrange to have 
at least three letters of recommendation sent, as per instructions on the 
academicjobsonline website. The starting date is negotiable. For more 
information about the position, see 
https://www.chess.cornell.edu/macchess-program-director-senior-research-associate.

Cornell University requires all employees, to be fully vaccinated against 
COVID-19, or to have obtained a university-approved medical or religious 
exemption.

Diversity and Inclusion are a part of Cornell University’s heritage. We’re a 
recognized employer and educator valuing AA/EEO, Protected Veterans, and 
Individuals with Disabilities.



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[ccp4bb] Beamline Scientist position at MacCHESS

[Doletha Marian Szebenyi]

The Macromolecular Diffraction Facility of the Cornell High-Energy Synchrotron 
Source (MacCHESS) has an opening for a Staff Scientist (Research Associate) to 
run the Flexible Crystallography (FlexX) station. Duties include both support 
of users performing routine macromolecular crystallography (MX) and development 
of novel techniques in X-ray scattering as applied to structural biology. User 
support includes continuing developments to maintain a
state-of-the-art facility. Novel techniques are developed in collaboration with 
scientists who need capabilities beyond the current standard methods. Areas of 
particular interest are crystallography at (1) ambient temperature, including 
serial techniques, and (2) high pressure, in a diamond anvil cell (DAC) or
using the high pressure cryocooling technique, especially for the trapping of 
intermediate states of reactions in crystallo.

Applicants should have a Ph.D. in a relevant field (biophysics, structural 
biology etc.), and at least 3 years of experience beyond the degree. Preference 
will be given to those with experience with methods related to X-ray scattering 
experiments, and to those who have worked at a synchrotron facility. Good clear 
communication skills are a must, including fluency in the English language.

Appointments are nominally for three years and are renewable, contingent upon 
availability of funds and employee performance.

Located on an Ivy League university campus in picturesque upstate New York, the 
Cornell High-Energy Synchrotron Source (CHESS) serves a world-wide user base of 
structural biologists, chemists, physicists, and engineers. MacCHESS is an 
NIH-supported National Resource providing support for structural biology at 
CHESS.

Applications should be submitted at http://academicjobsonline.org/ (posting 
#20601) and should include a cover letter, a CV, a list of
publications, and a detailed summary of research experience and interests. 
Please arrange to have at least three letters of recommendation sent, as per
instructions on the academicjobsonline website. The starting date is 
negotiable. For more information about the position, see
https://www.chess.cornell.edu/macchess-staff-scientist.

Cornell University requires all employees, to be fully vaccinated against 
COVID-19, or to have obtained a university-approved medical or religious
exemption.

Diversity and Inclusion are a part of Cornell University’s heritage. We’re a 
recognized employer and educator valuing AA/EEO, Protected Veterans, and
Individuals with Disabilities.



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[ccp4bb] Structural Biologist opening at H3 Biomedicine (Cambridge - USA)

[Nicholas Larsen]

Hi All,
We have an exciting job opportunity in structural biology!  *Please apply
at:*
https://us.eisai.com/careers-at-eisai/job-detail?searchParam=H3%20Biomedicine=JOB_POSTING-3-9560

H3 is an oncology-focused company leveraging the latest cancer genomics
data to inform drug discovery.  The qualified candidate will have a Ph.D.
and postdoc with 2-4 years of relevant industry experience.  They will be
responsible for leading structure based drug design efforts using x-ray
crystallography and cryo-EM methods, as required.  The candidate will also
manage CRO relationships and possible academic collaborations.

*Basic qualifications:*

Molecular Biology (construct design)

Expression (from E coli, insect & mammalian systems) and purification (AKTA)

Automation (Mosquito, DragonFly, RockMaker, etc)

Co-crystallization, seeding, cross-seeding, soaking, harvesting, freezing,
etc.

Molecular Replacement, CCP4, Coot, Pymol or Chimera, Heavy atom of Se-Met
phasing

Grid preparation & freezing

Relion, cisTEM, CCP-EM, etc

Two or more first author publications.

Team player and excellent communication skills

*Additional desired qualifications:*
Knowledge of drug discovery & oncology.  Experience in biophysics.
Experience with cryo-EM.

-- 
Nick Larsen
Director - Lead Discovery
H3 Biomedicine | an Eisai Oncology Company
300 Technology Sq #5
Cambridge, MA 02139
Mobile: 617-792-4184

https://www.h3biomedicine.com/

-- 
[This e-mail message may contain privileged, confidential and/or 
proprietary information of H3 Biomedicine. If you believe that it has been 
sent to you in error, please contact the sender immediately and delete the 
message including any attachments, without copying, using, or distributing 
any of the information contained therein. This e-mail message should not be 
interpreted to include a digital or electronic signature that can be used 
to authenticate an agreement, contract or other legal document, nor to 
reflect an intention to be bound to any legally-binding agreement or 
contract.]



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[ccp4bb] Microbiology position at Florida State University

[M. Elizabeth Stroupe]

Dear all,

The Department of Biological Science at Florida State University is currently 
undergoing a search for an Assistant Professor in the broadly defined field of 
Microbiology.

Interested parties can find more information and apply to job ID 50256 here:

https://jobs.omni.fsu.edu/psc/sprdhr_er/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_SCHJOB_FL=U;

Best,

Beth

---

Dr. M. Elizabeth (Beth) Stroupe
Professor, Department of Biological Science
Director, Graduate Program in Molecular Bophysics
Institute of Molecular Biophysics
Florida State University
Tallahassee, FL 32306



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[ccp4bb] Scientific/Bioinformatics Software Developer at RCSB PDB (Rutgers)

[Jasmine Young]

   Dear all,

RCSB Protein Data Bank is seeking highly motivated, scientific software 
developers with domain experience in structural biology, bioinformatics 
or related fields. The candidate should be interested in structural 
biological data and enjoy engaging with other programmers and scientists 
in a collaborative team environment.



   Responsibilities:

 * Design, development, and deployment of modern data-intensive
   scientific applications, within a microservice architecture
 * Integration of complex bioinformatics data, implementation of
   specialised algorithms for search/data analysis and use of AI tools
 * Design and implementation of cloud-ready deployments using
   containerization and modern cloud technologies
 * Analysis, refactoring and adaptation of legacy code to conform to
   new architecture designs
 * Debugging, testing, troubleshooting


   Qualifications:

 * PhD or Master’s degree in Computer Science, Biochemistry,
   Bioinformatics, or a related discipline, or a comparable combination
   of education and experience developing modern scientific data
   applications
 * Excellent interpersonal, verbal, and written communication skills
 * Experience with Python, document databases (e.g., MongoDB), search
   and data access tools (e.g., ElasticSearch and GraphQL)

Scientific background in any of the following areas would be considered 
a major plus: Molecular Biology, Bioinformatics, Cheminformatics, 
Biochemistry, Chemistry, Genomics.


Experience working with large and complex scientific datasets would also 
be considered a plus.



   Outstanding Benefits Package

RCSB PDB is a friendly and collaborative working environment with 
excellent professional development opportunities. At Rutgers, this 
academic position offers New Jersey state benefits and a faculty-level 
salary. There are personal rewards including comprehensive health and 
retirement plan options.



   About RCSB PDB:

The work at RCSB PDB (rcsb.org) focuses on data analysis, integration, 
and transformation, and the presentation and visualization of data using 
complex interactive graphical user interfaces. An important aspect is to 
provide users with the ability to search and explore the PDB data 
archive. Solutions are implemented using a wide range of components 
developed and maintained in-house, in addition to third-party tools, 
libraries, frameworks and technologies. The candidate should be 
comfortable working in a dynamic environment, and able to demonstrate an 
ability to think creatively, generate new ideas, and implement 
solutions. The candidate should also show an eagerness to learn new 
skills and technologies.



   Apply at Rutgers:

https://jobs.rutgers.edu/postings/142529


--
Regards,

Jasmine

===
Jasmine Young, Ph.D.
Biocuration Team Lead
RCSB Protein Data Bank
Research Professor
Institute for Quantitative Biomedicine
Rutgers, The State University of New Jersey
174 Frelinghuysen Rd
Piscataway, NJ 08854-8087

Email:jasm...@rcsb.rutgers.edu
Phone: (848)445-0103 ext 4920
Fax: (732)445-4320
===



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[ccp4bb] 3 postdoc positions on structure-based drug discovery in the Yue lab at Newcastle University

[Wyatt W. Yue]

Dear all,

The Yue Lab, recently relocated to Newcastle, is recruiting 3 postdoc
positions offering exciting opportunities in different flavours of
structural biology/drug discovery, interacting closely with clinicians,
industry, and patient groups.

All are two-year positions in the first instance,
UK/EU/non-EU/international applicants all welcome.

Deadline: *Monday 13 December*. We aim to fill these positions by Q1 2022.



https://jobs.ncl.ac.uk/job/Newcastle-Research-Associate/711931801/ (job ID:
11461) You will drive a structure-based drug discovery project in an
academic setting, funded by LifeArc and Action Medical Research, working
closely with medicinal chemists in Oxford and clinical scientists in UCL
towards hit-to-lead inhibitor optimisation for a rare epileptic disorder.
(Skills: crystallography, SPR, activity assays, CETSA; bit of cryo-EM)

https://jobs.ncl.ac.uk/job/Newcastle-Research-Associate-in-Structure-Based-Drug-Design/711711601/
(job ID: 11462) You will run an academic-industrial collaboration with
Bicycle Therapeutics, towards structural and biophysical characterisation
of bicyclic peptides in complex with novel therapeutic targets in
immune-metabolism/oncology. (Skills: different expression approaches,
crystallography, SPR; bit of cryo-EM)

https://jobs.ncl.ac.uk/job/Newcastle-Research-AssistantAssociate-in-AI-&-fragment-based-drug-discovery/743752301/
(job ID: 13927) You will lead an early-stage discovery project funded by a
patient foundation, towards small molecule therapy for Friedreich’s ataxia
targeting a multi-protein complex. You will work closely with an AI company
in hit finding, and run validation studies to guide compound design through
machine learning (Skills: ITC, SPR, cryo-EM & x-ray, activity assays).



You can find out more about our group here:
https://www.staff.ncl.ac.uk/yuelab/

Any informal enquiries you can contact: wyatt@newcastle.ac.uk





*Wyatt Yue*

Professor of Structural Biology

Biosciences Institute

Faculty of Medical Sciences

Newcastle University NE2 4HH

Group: www.staff.ncl.ac.uk/yuelab/

Profile: wyattyue.github.io



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