date:20220426

[ccp4bb] Fwd: job opening: Scientist, X-ray Crystallography - San Diego, CA

2022-04-26 Thread Rui Xu

*Scientist, X-ray Crystallography - San Diego, CA*

Pharmaceuticals

*Job Description *

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's
Family of Companies is recruiting for a Scientist, X-ray Crystallography,
located in La Jolla, CA!

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are
working to create a world without disease. Transforming lives by finding
new and better ways to prevent, intercept, treat and cure disease inspires
us. We bring together the best minds and pursue the most promising science.
We are Janssen. We collaborate with the world for the health of everyone in
it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen
Research & Development, LLC is part of the Janssen Pharmaceutical
Companies.

The Discovery Technologies and Molecular Pharmacology group is a dynamic,
diverse and critical part of the Discovery Sciences organization in Janssen
R&D. We are committed to the discovery and characterization of high-quality
chemical leads needed for the generation of small molecule clinical
compounds in all five Janssen Therapeutic Areas. This mission requires deep
scientific expertise across broad subject areas including chemistry,
cellular and molecular pharmacology, enzymology, screening, protein
science, and structural biology coupled with an ability to work
collaboratively with internal and external partners. Building on a strong
legacy of success, we are currently seeking an outstanding and motivated
individual to join our team as Scientist, X-ray Crystallography.

*As the Scientist you will:*

   - Be an active member of drug discovery teams, working closely with
   computational and medicinal chemists on structure-based drug design
   approaches for small molecule agent optimization.
   - Be responsible for crystallization of protein-small molecule
   complexes, determination of high-resolution structures by X-ray
   crystallography and communicating these results to the project team.
   - Work closely with protein scientists, biophysicists, protein NMR and
   cryo-EM scientists as part of an integrated structural biology effort.
   - Contribute to multidisciplinary Fragment-Based Lead Discovery (FBLD)
   efforts.
   - Contribute to enhance the structural biology scientific expertise of
   the group by publishing high-impact research papers, and presenting at
   scientific conferences, internalizing impactful technologies and platforms,
   and establishing academic collaborations.
   - Mentor lab scientists and contribute to the strategic planning of the
   Structural Biology group.


*Qualifications*

   - BS degree with at least 12 years of experience, OR MS degree with at
   least 9 years of experience, OR a Ph.D. or equivalent and postdoctoral
   experience in structural biology (X-ray crystallography, biophysics,
   protein engineering) or related field is required
   - Expertise with crystallography software packages
   (Phenix/CCP4/PyMol/Moe) in a mixed Linux/Windows computational environment
   is required
   - Scientific expertise in structural biology, with strong experience in
   both protein crystallization and structure determination is required
   - Strong record of external publications and presentations is required
   - Outstanding written and oral communication skills are required
   - Experience in Structure-Guided Drug Design utilizing X-ray
   crystallography is preferred
   - Research experience in cryo-electron microscopy (Cryo-EM),
   Micro-electron diffraction (Micro-ED), protein NMR or orthogonal structural
   biology technologies is preferred
   - Research experience with other biophysical techniques such as MST,
   ITC, NMR, DSF, SPR is preferred
   - Broad knowledge of biophysics, biochemistry, molecular pharmacology,
   and protein sciences is preferred.
   - Experience in scientific programming (Unix shells, Python) is preferred
   - Expertise in one or more of the following therapeutic areas: Oncology,
   Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is
   preferred

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without
regard to race, color, religion, sex, sexual orientation, gender identity,
age, national origin, or protected veteran status and will not be
discriminated against on the basis of disability.


*Primary Location*
United States-California-San Diego-
*Organization*
Janssen Research & Development, LLC (6084)
*Job Function*
R&D
*Requisition ID*
2005866689W



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[ccp4bb] Job opening

2022-04-26 Thread Ronnie

Posting for a friend: Head of Biochemistry position at Sequris: Head of 
Biochemistry 
  
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Head of Biochemistry
 
Job Summary The Head of Biochemistry is responsible for developing strategy, 
planning, and evaluating projects in the field of biochemistry and evaluating 
projects within Seqirus and external opportunities. This position will lead the 
vaccine antigen
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Best,Ronnie 



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[ccp4bb] Two positions available at DESY in Hamburg

2022-04-26 Thread Thomas White

Hi everyone,

For people who are interested in programming and software engineering,
we have two positions available in the photon science department at
the Deutsches Elektronen-Synchrotron DESY in Hamburg.


The first position is a scientific role within the Center for Data and
Computing in Natural Sciences (https://www.cdcs.uni-hamburg.de/) where
you will develop and implement new algorithms for data analysis:

Scientist/postdoctoral fellow - computational photon science
https://v22.desy.de/e67416/records129838/index_eng.html


The second position is a technical role (PhD *not* required) as part of
DAPHNE4NFDI (https://www.daphne4nfdi.de/) where you will support
large-scale data handling by handling cross-platform software
deployment:

Scientist for cross-platform software development
https://v22.desy.de/e67416/records161181/index_eng.html


In addition to the contact details given on the job adverts, you're more
than welcome to contact me directly for further details.

Best wishes,

Tom

-- 
Thomas White  



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[ccp4bb] postdoc opportunity at Imperial College London

2022-04-26 Thread Bubeck, Doryen A

Dear all,

I'd like to call your attention to a new job opportunity within the Bubeck lab
at Imperial College London using cryoEM to explore how bacteria evade immune
killing. You can apply at the following:

https://www.imperial.ac.uk/jobs/description/NAT01088/research-associate-structural-biology-membrane-attack-complex.

Reference NAT01088
Date posted 26 April 2022Closing date 24 May 2022

Job summary

Two Research Associates with expertise in structural biology, and in membrane
biophysics are sought. Joining a collaborative research team with the Bubeck
lab at Imperial College London and
the Wallace lab at King’s College London we aim to
uncover how the membrane attack complex (MAC) kills bacterial pathogens in the
context of the cell envelope.

Duties and responsibilities

Funded by a five year Wellcome Trust Investigator Award, the project’s
objectives are to discover (1) where MAC is located within the bacterial
envelope and (2) how MAC activation controls bacterial killing. You will join
an exciting interdisciplinary team of structural biologists and membrane
biophysicists to tackle this major outstanding question in understanding
host-pathogen interactions. Linking cryo electron tomography and
superresolution studies of MAC within the context of a series of novel mimics
of the Gram-negative cell envelope, the research builds on a combined
track-record in complement structural biology and artificial membranes.

Essential requirements

Research Associate 1 (Research Associate in Structural Biology of the Membrane
Attack Complex), based in the Bubeck lab at Imperial College London, will hold
a PhD (or equivalent) in structural biology, ideally with experience in
cellular tomography. You must have a strong research track record in studying
protein-protein and protein-membrane complexes preferably demonstrated by first
author publications in international journals. Experience in the design and
execution of workflow for structure determination of proteins or cellular
systems from sample preparation to acquisition and analysis of structural
biology data. Additional expertise in microbiology is very suited for the
position. This is a full-time, fixed-term appointment available for up to 36
months. Please see the attached Job Description and Person Specification for
the full list of requirements.

Research Associate 2 (Research Associate in Artificial Cell Envelopes) based in
the Wallace lab at King’s College London will focus on building new artificial
and biohybrid models of the gram-negative cell envelope, compatible with
single-molecule and superresolution fluorescence imaging and cryo electron
tomography. You will hold a PhD (or equivalent) in membrane biophysics, optical
microscopy or multiphase microfluidics. Experience in artificial membranes,
superresolution microscopy, microbiology, and microfluidics are desirable. This
is a full-time, fixed-term appointment available for up to 48 months.

Both posts require excellent verbal and written communication skills, and be
able to write clearly and succinctly for publication. You must also be able to
relate well with others, form positive relationships with a wide range of
people and to work as part of a team, as well as independently. The ability to
develop and apply new concepts, have a creative approach to problem-solving,
and to set and attain research objectives in a multidisciplinary team are also
essential.

Best wishes,

Doryen
___

Dr. Doryen Bubeck
Director Centre for Structural Biology
Department of Life Sciences
Imperial College London

https://www.imperial.ac.uk/people/d.bubeck
@bubecklab

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Re: [ccp4bb] Group Head CryoEM/Structural Biology in Sanofi

2022-04-26 Thread jlliu20022002 liu

Hi All,

Please see the following job ads for a structural biology group leader
position in Sanofi. Please apply at the job application site not to this
email.  Thanks a lot!

Jinyu
-

Dear Colleagues,

We seek a cryo EM expert to lead the Boston-area SB group within Sanofi’s
global Integrated Drug Discovery research division.  This team will move
into Sanofi’s new research HQ campus in Cambridge US, opening in 2022, with
a Glacios EM facility.

https://jobs.sanofi.us/job/waltham/group-head-cryoem-structural-biology/507/27677708016

Please notify colleagues of this opportunity to join a network of
accomplished structural biologists and drug discovery scientists from all
disciplines.

Best Wishes,

Hans Biemann

*Hans-Peter Biemann, Ph.D.*

Distinguished Scientist

Sanofi US
hans-peter.biem...@sanofi.com

153 Second Ave - Waltham – MA 02451  US

On Tue, Apr 26, 2022 at 10:42 AM jlliu20022002 liu 
wrote:

> Hi All,
>
> Sorry for the job ads. Just want to draw your attention that the following
> position is available in Sanofi. You are encouraged to apply if you think
> you fit the job description.
>
> Thank you!
>
> Jinyu
>
> https://jobs.sanofi.us/job/-/-/507/27677708016?p_sid=YgkboFb&utm_medium=jobad&ss=paid&utm_campaign=fy22_annual&utm_content=pj_board&utm_source=indeed&p_uid=It17uXLdRF&dclid=CI2doLj5sfcCFcqWnwodHpENgQ
>
>
>
>
>

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[ccp4bb] Group Head CryoEM/Structural Biology in Sanofi

2022-04-26 Thread jlliu20022002 liu

Hi All,

Sorry for the job ads. Just want to draw your attention that the following
position is available in Sanofi. You are encouraged to apply if you think
you fit the job description.

Thank you!

Jinyu
https://jobs.sanofi.us/job/-/-/507/27677708016?p_sid=YgkboFb&utm_medium=jobad&ss=paid&utm_campaign=fy22_annual&utm_content=pj_board&utm_source=indeed&p_uid=It17uXLdRF&dclid=CI2doLj5sfcCFcqWnwodHpENgQ



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[ccp4bb] Post doctor in NMR-based structural biology

2022-04-26 Thread Magnus Wolf-Watz

Post doctor in NMR-based structural biology

A postdoc position in solid-state/liquid structural NMR is opened in the groups 
of Gerhard Gröbner and Magnus Wolf-Watz, University of Umeå, Sweden. The 
position has the main focus on structure determination of membrane-bound 
proteins of the Bcl-2 family involved in apoptosis but also has a component 
with human protein kinases or small molecule kinases. Depending on the 
candidate the project may also include structural studies with single particle 
cryo EM. The position and more info is found on the website 
(www.umu.se/en/work-with-us/open-positions/) and named "Post doctor in 
NMR-based structural 
biology". Do 
not hesitate to contact Gerhard Gröbner 
(gerhard.grob...@chem.umu.se) or Magnus 
Wolf-Watz (magnus.wolf-w...@umu.se )

Best wishes
Gerhard and Magnus




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[ccp4bb] PhD vacancy at the Nanoscopy division of M4I at the University of Maastricht

2022-04-26 Thread Anita Mühlegger

The Nanoscopy division of the Maastricht Multimodal Molecular Imaging institute 
(M4I) at the University of Maastricht is looking for a PhD candidate in 
Structural Biology of Tuberculosis
 
JOB DESCRIPTION
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium 
Tuberculosis. Even though TB is curable, about one and a half million people 
succumb to it every year. Current treatments are long and with side effects: 
the need for new antibiotics and vaccines is obvious.
We aim to understand how gene products or proteins work within their cellular 
environment in health and disease. Our institute houses a state of the art 
cryo-Light Microscopy/Electron Microscopy correlative workflow from cellular 
localization, milling with focused ion beam (FIB-SEM), down to cryo-electron 
tomography, subvolume averaging and image processing to study how these 
nano-machines work under native conditions.
We seek a talented PhD candidate to join our interdisciplinary team. Our 
biology research focuses on unraveling, controlling and tempering the 
pathogenicity of Mycobacterium tuberculosis at a molecular level. The applicant 
will apply biochemistry to purify and characterize molecular players in 
isolation. The structural characterization will be mainly done by single 
particle analysis.
PhD Job Title: Structural insight in Mycobacterium Tuberculosis pathogenicity.
PhD advisers: Peter J. Peters and Raimond Ravelli
Organisation Unit: Nanoscopy division of the Maastricht Multimodal Molecular 
Imaging institute (M4I).
 
See the details of this position here: 
https://www.academictransfer.com/nl/311281/phd-candidate-in-structural-biology-of-tuberculosis-institute-m4i-division-nanoscopy-faculty-of-health-medicine-and-life-sciences/

For more information about this position please contact:
Peter Peters, mail to: pj.pet...@maastrichtuniversity.nl
Raimond Ravelli, mail to: rbg.rave...@maastrichtuniversity.nl
Carmen López-Iglesias, mail to: c.lopezigles...@maastrichtuniversity.nl

Make sure to apply no later than 11 May 2022 23:58 (Europe/Amsterdam) by 
pressing the button ‘apply now’ on the following link: 
https://www.academictransfer.com/nl/311281/phd-candidate-in-structural-biology-of-tuberculosis-institute-m4i-division-nanoscopy-faculty-of-health-medicine-and-life-sciences/



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[ccp4bb] Reminder: Data Visualisation Software Engineer position at PDBe

2022-04-26 Thread David Armstrong


Dear Colleagues,

We are looking to recruit a software engineer who is interested in 
advanced data visualisation tools for 3-dimensional macromolecular 
structure data to join the Protein Data Bank in Europe (PDBe) team at 
the European Bioinformatics Institute (EMBL-EBI). This is a 
collaborative project between PDBe and RCSB Protein Data Bank.


This is a technical role, working together with developers and curators 
from PDBe and RCSB PDB to create infrastructure for integrating 
multi-scale macromolecular structure data and providing FAIR access to 
these data. You will expand the 3-dimensional graphics viewer, Mol*, and 
will create novel data visualisation tools that will power the web 
applications of several core data resources.


The closing date for this post is 13th May 2022.

For more information on the position, please visit:
https://www.ebi.ac.uk/pdbe/about/jobs

Kind regards,
David

--
David Armstrong
Outreach and Training Lead
PDBe
European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SD UK
Tel: +44 1223 492544



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[ccp4bb] postdoc fellowship in structural studies of virus replication

2022-04-26 Thread Lars-Anders Carlson


Dear all,
Quick reminder of an open postdoc position in my group. Deadline 
approaching (30 April).


www.carlsonlab.se/join

We offer a customizable project in structural virology, focussing on 
structural aspects of RNA virus replication. This could be ideal for a 
biochemist or virologist keen to learn cryo-EM and cryo-ET, or a 
microscopist who wants to expand their wetlab skills to virology, cell 
biology and biochemistry. Ultimately, your passion and creativity may 
outweigh any other criteria so we are open to applicants with other 
skill sets.


We are located in Umeå, Sweden, on a campus with a strong focus on 
infection biology and state-of-the-art facilities for cryo-EM and other 
structural methods.


Get in touch in case of any questions.

Best wishes,
Lars



--
Lars-Anders Carlson
Assistant Professor
Dept of Medical Biochemistry and Biophysics
Wallenberg Centre for Molecular Medicine
Molecular Infection Medicine Sweden
Umeå University
901 87 Umeå, Sweden
http://www.carlsonlab.se/



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[ccp4bb] Call for abstract: ECM33 Multiple crystal and serial crystallography session

2022-04-26 Thread Gianluca SANTONI


Dear colleagues,
for the upcoming ECM33 meeting in Versailles ( www.ecm33.fr) we are 
organizing the microsymposium


'Serial crystallography & obtaining structures from many crystals'.

We would like to focus both on new data collection or analysis methods, 
and new structures solved by using multiple crystals.
Ilme Schlichting and Azadeh Shahsavar kindly agreed to start this 
session. Please consider submitting an abstract when registering to the 
conference. We will select 4 oral contributions.

We are looking forward to meet you in Versailles!

Selina Storm and Gianluca Santoni



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