Sent on behalf of Prof. Paul Wyatt……..
Dear all,
A position is available for a structural biologist to work within the Drug
Discovery Unit at the University of Dundee.
Details are outlined below – all applications will be processed through the
www.dundee.ac.uk/jobs website quoting reference LS0351
Thanks
David
Reference Number: LS0351
Job Title: Structural Biologist
College: College of Life
Sciences
School: Life Sciences Research
Division: Biological Chemistry and DrugDiscovery
Grade: Grade 7 (£29,249 - £35,938)
Job Category: Research
Closing Date: 20 August 2013
The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a
fully integrated drug
discovery operation based within a world class Life Sciences research
environment. Its remit is to complement BioPharma activities by tackling both
neglected diseases (sleeping sickness, leishmaniasis and malaria) and
validation of novel targets and mechanisms across a range of potential
therapeutics areas. The DDU works to Biotech style philosophy andstandards
incorporating, dynamic, goal driven project management based on Target Product
Profiles and Compound Selection Criteria. The project goals are therapeutic
area dependent but range from quality leads demonstrating disease model proof
of concept, through to pre-clinical candidates.
We are looking for a highly motivated structural biologist, to work as part of
our drug discovery efforts. The main role will include design of protein
constructs, protein expression purification, crystallisation, solution of
x-ray structures and co-crystallisation studies to support in house
fragment-based and structure-based drug discovery. We have access to an
in-house x-ray diffractometer and to synchrotron sources externally. You will
have structure-based drug discovery experience. You will be part of a BioPharma
experienced multi-disciplinary team in the DDU, consisting of hit discovery
scientists, medicinal chemists, computational chemists and DMPK scientists, as
well as structural biologists. The post isavailable immediately. Salary will
depend on experience, but will be between £29,249 and £35,938.
Your responsibilities:
• Contribute to drug discovery projects, through determination of
ligand-protein structures and input into the design process.
• Fragment-based drug discovery.
Knowledge, qualifications, skills and experience:
• Candidates must be professionally qualified with a PhD in structural biology.
• Expertise in design of protein constructs, protein expression purification,
crystallisation, solution of x-ray structures and co-crystallisation studies
to support in house fragment-based and structure-based drug discovery.
• A thorough understanding of protein-ligand interactions.
• Familiarity and understanding of software related to structural biology.
• Understanding and appreciation of the drug discovery process is an advantage
• Strong interpersonal, communication and presentation skills
• Good time management, organizational and communication skills.
A few facts about The College of Life Sciences at Dundee:
• The College of Life Sciences has over 900 research and support staff from 59
countries and external funding in excess of £40 million per year
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of
scientists conducted by The Scientist magazine
• The College of Life Sciences has been consistently rated ‘5-star’ (the
highest rating) by the
UK national Research Assessment Exercise.
Dundee, set on the east coast of Scotland, lies in an area of outstanding
natural beauty, including large sandy beaches and challenging hills.
How to apply:
To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to
apply on-line please contact Human Resources on (01382) 386209 (answering
machine) for an application pack. Please quote reference number LS0351.
The University of Dundee is committed to equal opportunities and welcomes
applications from all sections of the community.
The University of Dundee is a Scottish Registered Charity, No. SC015096.
Dr David Robinson
Structural Biologist
Drug Discovery Unit
Division of Biological Chemistry and Drug Discovery
College of Life Sciences
James Black Centre
University of Dundee
