[ccp4bb] Protein Crystallographer position at Sosei Heptares
We are currently seeking a Protein Crystallographer to join the crystallography team. You will be responsible for the structure determination of membrane proteins to support Sosei Heptares’ drug discovery efforts. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. For more details about this role and how to apply please visit our careers website: https://cezanneondemand.intervieweb.it/heptares/jobs/protein_crystallographer_24823/en/ Regards, Mat. To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Closing date approaching - Membrane Protein Biochemist Position at Sosei Heptares
We are now seeking a highly experienced membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants should possess a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals. This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company. The successful candidate is expected to: • Express and purify membrane proteins • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists • Prepare and effectively present results (written and oral) to project teams • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements: The preferred candidate will have the following: • Candidates should possess a PhD in biochemistry, biophysics or a related discipline • Candidates should have experience in membrane protein expression, purification and characterisation in either an academic or industry setting • Possess extensive molecular biology skills • Knowledgeable in prokaryotic and eukaryotic expression vectors and be experienced in their manipulation • Well-versed in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies • Expert in the expression of membrane proteins from mammalian and insect cells • Proficient in the purification and extensive biochemical characterisation of membrane proteins • Experienced in the reconstitution of purified membrane proteins in membrane-mimetic environments • Familiar with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques • Candidates should understand the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) • Candidates should be highly organised Other information The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2021-2BMS. The closing date for applications is 30th March 2021. Strictly no agencies To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Membrane Protein Biochemist Position at Sosei Heptares
We are now seeking a highly experienced membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants should possess a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals. This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company. The successful candidate is expected to: • Express and purify membrane proteins • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists • Prepare and effectively present results (written and oral) to project teams • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements: The preferred candidate will have the following: • Candidates should possess a PhD in biochemistry, biophysics or a related discipline • Candidates should have experience in membrane protein expression, purification and characterisation in either an academic or industry setting • Possess extensive molecular biology skills • Knowledgeable in prokaryotic and eukaryotic expression vectors and be experienced in their manipulation • Well-versed in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies • Expert in the expression of membrane proteins from mammalian and insect cells • Proficient in the purification and extensive biochemical characterisation of membrane proteins • Experienced in the reconstitution of purified membrane proteins in membrane-mimetic environments • Familiar with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques • Candidates should understand the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) • Candidates should be highly organised Other information The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2021-2BMS. The closing date for applications is 30th March 2021. Strictly no agencies To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Closing Date Approaching: Protein Biochemist positions at Sosei Heptares
We are now seeking an experienced membrane protein biochemist to join the Protein Expression and Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spec, crystallisation and cryoEM facilities. Applicants should be proficient in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. A proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals is highly desirable. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. The successful candidate is expected to: - Express and purify challenging membrane proteins - Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins - Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation - Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists and structural biologists - Prepare and effectively present results (written and oral) to program teams Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements - Candidates should have or are about to obtain a PhD in biochemistry, biophysics or a related discipline - Possess extensive molecular biology skills and be knowledgeable in expression construct design and engineering - Proficient in the expression of membrane proteins from baculovirus/insect cells and/or mammalian cells - Proficient in the purification and extensive biochemical characterisation of membrane proteins - Familiar with the biochemical and biophysical techniques used to characterise proteins such as luminescence, fluorescence and FRET-based techniques - Candidates should understand the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spec) Other information *Applicants must be able to demonstrate proof of the right to work in the United Kingdom.* The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2020-5BMS. *The closing date for applications is 4th September 2020* Strictly No Agencies To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Protein Biochemist position at Sosei Heptares
We are now seeking an experienced membrane protein biochemist to join the Protein Expression and Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spec, crystallisation and cryoEM facilities. Applicants should be proficient in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. A proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals is highly desirable. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. The successful candidate is expected to: - Express and purify challenging membrane proteins - Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins - Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation - Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists and structural biologists - Prepare and effectively present results (written and oral) to program teams Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements - Candidates should have or are about to obtain a PhD in biochemistry, biophysics or a related discipline - Possess extensive molecular biology skills and be knowledgeable in expression construct design and engineering - Proficient in the expression of membrane proteins from baculovirus/insect cells and/or mammalian cells - Proficient in the purification and extensive biochemical characterisation of membrane proteins - Familiar with the biochemical and biophysical techniques used to characterise proteins such as luminescence, fluorescence and FRET-based techniques - Candidates should understand the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spec) Other information *Applicants must be able to demonstrate proof of the right to work in the United Kingdom.* The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2020-5BMS. The closing date for applications is 4th September 2020 Strictly No Agencies To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] REMINDER closing date approaching: Protein Biochemist Position at Sosei Heptares, Cambridge UK
We are now seeking an experienced protein biochemist to join the Biomolecular Structure group at our research facility on Granta Park, Cambridge, UK, working on GPCR structure determination to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spec, crystallisation and cryoEM facilities. Applicants should be proficient in the expression and purification of membrane proteins destined for biophysical and structural studies. A proven track record of publications related to the expression and purification of difficult membrane protein targets in peer-reviewed journals is desirable. Knowledge of biophysical (SPR, mass-spec) and/or structure determination techniques (X-ray, cryoEM) of membrane proteins would be a distinct advantage. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. *Applicants must be able to demonstrate proof of the right to work in the United Kingdom.* Applications should include a covering letter, providing a short description of the background to their interest in the role, with a curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, quoting reference number 2019/3BMS. The closing date for applications is 13th October 2019. Strictly, no agencies. Please do not reply directly to this email and apply through the portal: https://cezanneondemand.intervieweb.it/app.php?module=annunci=heptares=biochemist_7491=en ReplyForward To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] REMINDER closing date approaching: CryoEM Scientist Position at Sosei Heptares Cambridge UK
We are seeking an experienced cryo-electron microscopy scientist to join the Biomolecular Structure group at our research facility on Granta Park, Cambridge, UK, working on GPCR structure determination to enable drug discovery efforts. At Sosei Heptares we are equipped with a ThermoFisher Glacios 200keV microscope and purpose-built sample preparation facilities. Applicants should be proficient in the preparation and optimisation of sample grids and have extensive expertise in the operation of new generation electron microscopes, high-resolution data collection, on the fly data analysis, automated pre-processing pipelines and high-resolution model reconstruction. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. For more information about the company, role, requirements and how to apply please see our website and visit the careers section: https://soseiheptares.com/ The closing date for applications is 3rd October 2019. To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] Protein Biochemist Position at Sosei Heptares
We are now seeking an experienced protein biochemist to join the Biomolecular Structure group at our research facility on Granta Park, Cambridge, UK, working on GPCR structure determination to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spec, crystallisation and cryoEM facilities. Applicants should be proficient in the expression and purification of membrane proteins destined for biophysical and structural studies. A proven track record of publications related to the expression and purification of difficult membrane protein targets in peer-reviewed journals is desirable. Knowledge of biophysical (SPR, mass-spec) and/or structure determination techniques (X-ray, cryoEM) of membrane proteins would be a distinct advantage. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with a curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, quoting reference number 2019/3BMS. The closing date for applications is 13th October 2019. Strictly, no agencies. Please do not reply directly to this email and apply through the portal: https://cezanneondemand.intervieweb.it/app.php?module=annunci=heptares=biochemist_7491=en To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] CryoEM Scientist Position at Sosei Heptares Cambridge UK
We are seeking an experienced cryo-electron microscopy scientist to join the Biomolecular Structure group at our research facility on Granta Park, Cambridge, UK, working on GPCR structure determination to enable drug discovery efforts. At Sosei Heptares we are equipped with a ThermoFisher Glacios 200keV microscope and purpose-built sample preparation facilities. Applicants should be proficient in the preparation and optimisation of sample grids and have extensive expertise in the operation of new generation electron microscopes, high-resolution data collection, on the fly data analysis, automated pre-processing pipelines and high-resolution model reconstruction. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. For more information about the company, role, requirements and how to apply please see our website and visit the careers section: https://soseiheptares.com/ The closing date for applications is 3rd October 2019. To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] CryoEM Scientist Position at Sosei Heptares, Cambridge UK
Sosei Heptares is an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. We are seeking an experienced cryo-electron microscopy scientist to join the biophysics group working on GPCR structure determination to enable drug discovery efforts. At Sosei Heptares we are equipped with a ThermoFisher Glacios 200keV microscope and purpose-built sample preparation facilities. Applicants should be proficient in the preparation and optimisation of sample grids and have expertise in the operation of high end, high voltage electron microscopes, high-resolution data collection including image processing, automated pre-processing pipelines and high-resolution model reconstruction. For further details about the position and for information on how to apply please follow the link: https://cezanneondemand.intervieweb.it/heptares/jobs/cryoelectron_microscopy_scientist_5637/en/ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
