[ccp4bb] UMMS Postdoctoral Job Posting - Korostelev Lab

[Powers, Ann]

Good afternoon,

Please take note of the below postdoctoral job posting opportunity.   Best 
regards, Ann Powers on behalf of Andrei Korostelev, Ph.D.

Postdoctoral position in cryo-EM and translation regulation ‒ from bacteria to 
neurons
Korostelev Lab, University of Massachusetts Medical School
We study how the ribosome interacts with numerous cellular components to 
achieve high accuracy and efficiency of gene expression. We’d like to 
understand the key roles of translation and ribosomes in: (1) Neurodevelopment 
and neurodegenerative diseases; (2) Bacterial stress signaling and gene 
regulation (e.g. coupling with transcription); and other aspects of gene 
expression (https://www.umassmed.edu/korostelev-lab/). We use a range of 
approaches, including cryo-EM and biochemistry (see selected references below).
Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and 
highly interactive research community: 
https://www.umassmed.edu/rti/about-the-rti/faculty-members/.  Our colleagues 
are interested in nearly all aspects of RNA biology, from small to large RNAs 
to RNA chemistry and therapeutics development.
We seek a highly motivated person who very recently received a PhD, or will 
soon receive a PhD.  Applications sent prior to the dissertation defense date 
are welcome.
If you are interested in using single-particle cryo-EM and in situ (cellular) 
EM to elucidate cellular mechanisms, submit the following information to 
ann.pow...@umassmed.edu:
1)  Your CV (including your publication list);
2)  Cover letter (less than 2 pages) describing:
 (i) your previous work - focusing on your most interesting finding(s),
 (ii) your scientific interests,
 (iii) which aspects of translation regulation are of interest to you.
3)  Email addresses of three references.
Selected publications (accessible via the provided links):
•Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. “ArfB 
can displace mRNA to rescue stalled 
ribosomes”. Nature Commun. 
2020.
•Loveland AB, Demo G, Korostelev AA. “Cryo-EM of elongating ribosome 
with EF-Tu GTP elucidates tRNA 
proofreading”. Nature. 2020.
•Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, 
Korostelev AA. “Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and 
poly-GR proteins revealed by 
cryo-EM”.
 bioRxiv. 2020.
•Susorov D, Egri S, Korostelev AA. "Termi-Luc: a versatile assay to 
monitor full-protein release from 
ribosomes”.
 RNA. 2020.
•Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. “Extensive 
ribosome and RF2 rearrangements during translation 
termination”. eLife. 2019.
•Loveland AB, Demo G, Grigorieff N, Korostelev AA. “Ensemble cryo-EM 
elucidates the mechanism of translation 
fidelity”.
 Nature. 2017.
•Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, 
Grigorieff N, Nudler E, Korostelev AA. “Structure of RNA polymerase bound to 
ribosomal 30S subunit”. eLife. 2017.
•Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. “Ensemble 
cryo-EM uncovers inchworm-like translocation of a viral IRES through the 
ribosome”. eLife. 2016.
•Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, 
Korostelev AA. “Ribosome•RelA structures reveal the mechanism of stringent 
response activation”. eLife. 2016
https://twitter.com/korostelevlab


Best regards,

 Ann Powers
 Administrative Coordinator for Dr. Andrei Korostelev
  [mass_rna-intitute_logo]
 University of Massachusetts Medical School
 368 Plantation Street, AS4-1046B
 Worcester, MA 01605
 774 455 4205
 ann.pow...@umassmed.edu






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[ccp4bb] Postdoctoral Position - Job Posting for Korostelev Lab at UMMS

[Powers, Ann]

Good morning,

Would you be so kind as to post the attached and below referenced job posting 
for the Korostelev Lab at UMass Medical School?

Many thanks.  Ann Powers

Postdoctoral position open at the University of Massachusetts Medical School, 
in the Korostelev Lab: https://www.umassmed.edu/korostelev-lab/.
We study translation regulation, using cryo-EM and biochemistry. We are 
particularly interested in: (1) Translation accuracy; (2) Ribosome's central 
role in bacterial stress signaling and gene regulation; (3) Neurodegenerative 
and other diseases, which originate from dysregulation of translation. 
References to some lab publications are provided below.

Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and 
highly interactive research community: 
https://www.umassmed.edu/rti/about-the-rti/faculty-members/. Our colleagues are 
interested in nearly all aspects of RNA biology, from small to large RNAs to 
RNA chemistry and therapeutics development.

We seek a highly motivated person who very recently received a PhD, or will 
soon receive a PhD.  Applications sent prior to the dissertation defense date 
are welcome.

Please submit the following information via email to: 
ann.pow...@umassmed.edu
1)   your CV (including publication list);
2)   in less than 2 pages, an outline of your:
 (i) previous work - focusing on your most interesting finding(s);
 (ii) your current/future scientific interests, and whether/which aspects 
of translation regulation sound interesting to you;
3)   email addresses of three references.

Selected publications (accessible via the provided links):
-  Svidritskiy et al. "Extensive ribosome and RF2 rearrangements during 
translation termination". eLife. 2019.
-  Loveland et al. "Ensemble cryo-EM elucidates the mechanism of 
translation 
fidelity".
 Nature. 2017.
-  Demo et al. "Structure of RNA polymerase bound to ribosomal 30S 
subunit". eLife. 2017.
-   Abeyrathne et al. "Ensemble cryo-EM uncovers inchworm-like 
translocation of a viral IRES through the 
ribosome". eLife. 2016.
-   Loveland et al. "Ribosome*RelA structures reveal the mechanism of 
stringent response activation". 
eLife. 2016.
Best regards,

 Ann Powers
 Administrative Coordinator for Dr. David Grunwald, Dr. Andrei 
Korostelev, and Dr. Athma Pai
  [mass_rna-intitute_logo]
 University of Massachusetts Medical School
 368 Plantation Street, AS4-1046B
 Worcester, MA 01605
 774 455 4205
 ann.pow...@umassmed.edu

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FINAL Postdoc-ad-announcement_Korostelevlab ccp4 10APR20.docx
Description: FINAL Postdoc-ad-announcement_Korostelevlab ccp4 10APR20.docx