Re: [ccp4bb] ISO model with large groups of atoms in alternative conformations

[SR Bharath]

Dear Pavel,

One of my colleagues solved this structure (
https://www.rcsb.org/structure/2gn0). I watched in awe while he built and
explained the structure.
Hopefully the structure is useful
-Bharath

On Tue, Aug 23, 2022 at 6:03 PM Pavel Afonine  wrote:

> Dear community,
>
>
>
> I’m looking for an example of a crystal structure where a large group of
> atoms (as large as a whole chain or even a domain) have more than one
> distinct conformation that would require modeling of such chain/domain as
> more than one individual copy, with each copy having partial occupancy. I’m
> not sure if that even exists but if someone can share an example that'd be
> very much appreciated!
>
>
>
> Thanks!
> Pavel
>
> --
>
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[ccp4bb] advert for PostDoc position @Singapore

[SR Bharath]

Dear Colleagues,



We are seeking an enthusiastic and self-motivated postdoctoral research
fellow to study proteins involved in maintaining genome stability and the
Hippo signaling pathway. We take a combinatorial approach of molecular
biology, biochemical and biophysical methods, and structural biology
(macromolecular crystallography and electron cryomicroscopy). ­Significant
aspects of our projects have translational potential. The candidate is
expected to be involved in the development of small molecules/peptides for
cancer therapeutics.



Singapore is an excellent environment to do research with many research
groups close by in Biopolis [https://www.a-star.edu.sg/imcb]. A*STAR offers
highly competitive salaries with benefits including housing allowance and
1-3 months performance bonus.



Requirements:

·   PhD in biochemistry, biophysics, molecular & cell biology or
in  medicinal
chemistry

·   Practical experiences in structural biology (Electron
Cryomicroscopy and/or X-ray crystallography) or in medicinal chemistry

·   Good publication record

·   Competent in scientific writing



Interested applicants should send a CV and three confidential letters of
reference to: Prof. Haiwei Song (Email: *hai...@imcb.a-star.edu.sg
*),
Institute of Molecular and Cell Biology, A*STAR, Singapore.


Cheers,

Bharath



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Re: [ccp4bb] PhD opportunity on Mycobacterial structural biology at Monash University, Melbourne

[SR Bharath]

zl...@imcb.a-star.edu.sg
On Sat, 21 Jul 2018 at 19:57, Rhys Grinter <
22087c81e8c6-dmarc-requ...@jiscmail.ac.uk> wrote:

> Dear All,
>
> There is an exciting opportunity to do a PhD co-supervised by Dr. Chris
> Greening and myself at Monash University, Melbourne. The project will
> investigate the structural basis for persistence in Mycobacterium
> tuberculosis, through the structural characterisation of the F420
> biosynthesis pathway. This multidisciplinary project will combine
> structural techniques (crystallography, cryo-EM), with biophysics,
> biochemistry and microbiology.
> https://www.findaphd.com/search/ProjectDetails.aspx?PJID=74941
>
> As well as being situated in Melbourne the worlds most liveable city,
> Monash University is within walking distance of the Australian Synchrotron
> and is home to a cutting edge Cryo-EM microscope facility. Making it a
> great place to do structural biology.
>
> Interested candidates should send their CV, academic transcript, and a
> brief outline of research interests and motivation to
> chris.green...@monash.edu.
>
> Please share with your colleagues and anyone interesting in starting a PhD
> in this exciting area.
>
> Best Wishes,
>
> Rhys
>
> --
> Dr Rhys Grinter
> Sir Henry Wellcome Fellow
> Monash University
> +61 (0)3 9902 9213
> +61 (0)403 896 767
>
> --
>
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Re: [ccp4bb] mystery feature near a PLP substrate

[SR Bharath]

It is most likely amino acrylate, the intermediate in the reaction of PLP
with amino acids.

On Wed, 24 May 2017 at 22:44, Francis Reyes 
wrote:

> Fidget spinner?
>
> https://en.m.wikipedia.org/wiki/Fidget_spinner
>
> F
>
> On May 24, 2017, at 10:16 AM, Eleanor Dodson 
> wrote:
>
> Any ideas?
>
> 
>
>