[ccp4bb] Postdoctoral Scholarship Opportunity in the Lane group (PBIO) CFEL/DESY, Hamburg, Germany
Uncovering protein dynamics: developing statistical crystallography Postdoctoral Scholarship Cluster of Excellence: Advanced Imaging of Matter Center for Free Electron Laser Science (CFEL), Hamburg, Germany Protein motion is at the heart of life, but remains challenging to witness firsthand. Proteins move to reading and copying DNA, convert sunlight into chemical energy, and transmit signals between cells, yet our ability to image these functions is limited by the technology we have to image protein dynamics. A new opportunity to meet this challenge is emerging, however, as crystallographic methods advance. We can now collect data from thousands to millions of crystals of the same protein, and it is clear no two crystals are identical. Thus, analyzing their distribution may reveal protein structural fluctuations directly. Can we develop a statistical crystallography to turn these large datasets into knowledge about protein dynamics? Can we use statistical analysis of crystal-to-crystal variation to separate signal from noise in time resolved experiments, revealing protein motion induced by mixing with a ligand or excitation with a pump laser? We seek a computational scientist who will answer these questions. As the ideal candidate, you will have the following key attributes: * A doctoral degree in physics, biophysics, chemistry, applied mathematics or a related field * Working knowledge of macromolecular crystallographic methods and software * A track record of scientific computing and programming * The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: * Mathematical modeling of protein dynamics and protein crystal diffraction data * Interpretation and analysis of experimental results * Open-source development to make your insights available to the broader scientific community * Presenting your work in written and oral form to the scientific community * Helping to foster an environment conductive to collaboration, learning, growth, and fun Available immediately is a two-year contract with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany. The group is housed at the Center for Free Electron Laser Science on the vibrant DESY campus (Luruper Chaussee 149, 22761 Hamburg, Germany). This position is funded through the Advanced Imaging of Matter Cluster of Excellence (https://www.cui-advanced.uni-hamburg.de/en.html). The successful candidate will become a fellow of the cluster and have access to career support, training opportunities, and an engaging scientific network via the cluster. The candidate will have additional technical and mentorship support from partners Andrea Thorne, Arwen Pearson, and Nicholas Pearce and their groups during the course of the project. We are an equal opportunity employer. Women and minorities are encouraged to apply and handicapped persons will be preferred given equal qualifications. Application deadline: 17 June 2021 Applications should include a cover letter, a tabular curriculum vitae, and copies of degree certificate(s). Please send applications by email to: For more details, write directly to TJ Lane: Cross-Posting on the AIM Cluster of Excellence page (funding source for this project): https://www.uni-hamburg.de/stellenangebote/ausschreibung.html?jobID=4c3ff9d2b6bcfbed3ee252108b0e5164fab487a9 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Postdoc in Hamburg (CFEL/HARBOR @ DESY) developing statistical crystallography
Uncovering protein dynamics: developing statistical crystallography Postdoctoral Position Center for Free Electron Laser Science (CFEL), Hamburg, Germany [DESY Campus] Protein motion is at the heart of life, but remains challenging to witness firsthand. Proteins move to reading and copying DNA, convert sunlight into chemical energy, and transmit signals between cells, yet our ability to image these functions is limited by the technology we have to image protein dynamics. A new opportunity to meet this challenge is emerging, however, as crystallographic methods advance. We can now collect data from thousands to millions of crystals of the same protein, and it is clear no two crystals are identical. Thus, analyzing their distribution may reveal protein structural fluctuations directly. Can we develop a statistical crystallography to turn these large datasets into knowledge about protein dynamics? Can we use statistical analysis of crystal-to-crystal variation to separate signal from noise in time resolved experiments, revealing protein motion induced by mixing with a ligand or excitation with a pump laser? We seek a computational scientist who will answer these questions. As the ideal candidate, you will have the following key attributes: • A doctoral degree in physics, biophysics, chemistry, applied mathematics or a related field • Working knowledge of macromolecular crystallographic methods and software • A track record of scientific computing and programming • The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: • Mathematical modeling of protein dynamics and protein crystal diffraction data • Interpretation and analysis of experimental results • Open-source development to make your insights available to the broader scientific community • Presenting your work in written and oral form to the scientific community • Helping to foster an environment conductive to collaboration, learning, growth, and fun Available immediately is a two-year contract with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany. The group is housed at the Center for Free Electron Laser Science on the vibrant DESY campus (Luruper Chaussee 149, 22761 Hamburg, Germany). This position is funded through the Advanced Imaging of Matter Cluster of Excellence (https://www.cui-advanced.uni-hamburg.de/en.html). The successful candidate will become a fellow of the cluster and have access to career support, training opportunities, and an engaging scientific network via the cluster. The candidate will have additional technical and mentorship support from partners Andrea Thorne, Arwen Pearson, and Nicholas Pearce and their groups during the course of the project. We are an equal opportunity employer. Women and minorities are encouraged to apply and handicapped persons will be preferred given equal qualifications. Application deadline: 17 June 2021 Applications should include a cover letter, a tabular curriculum vitae, and copies of degree certificate(s). Please send applications by email to: For more details, write directly to TJ: Also see our website: pbio.cfel.de To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Two Positions in the Photobiology Group at CFEL / DESY Hamburg
Hello Everyone, We have two open positions in my group available immediately. Feel free to get in touch with any questions or send along a CV & cover letter directly. TJ Lane Group Leader Center for Free Electron Laser Science --- *Understanding how proteins move by through multi-crystal analysis* Postdoctoral Position Center for Free Electron Laser Science (CFEL), Hamburg, Germany We know proteins make use of long-range motions to perform the essential functions of life: transmit signals, conduct chemistry, and mechanically alter the environment, but how proteins accomplish these amazing tasks remains unexplained at the atomic level. Experimentally measuring these long-range motions at atomic detail has been a challenge. Recently, our group had success in doing this for the main protease (Mpro) from SARS-COV-2, the virus behind the COVID pandemic. Many datasets on COVID and non-COVID proteins have been collected, but new methods are necessary to investigate and extract information about protein motions in these data — we seek a computational scientist to drive this work. As the ideal candidate, you will have the following key attributes: -- A doctoral degree in physics, biophysics, computer science, or a related field -- Excellent computational skills, including python and modern data science methods -- Capabilities in computational crystallography (serial crystallography a bonus but not required) -- Knowledge of the principles of protein structure and function -- The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: -- Writing software and scripting to perform data analysis on a daily basis -- Working with large, rich crystallographic datasets from synchrotrons and XFELs -- Analysis/interpretation of experimental data and results -- Helping to foster an environment conducive to collaboration, learning, growth, and fun The position offers a chance to work at a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science. Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the vibrant city of Hamburg, Germany. For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter: Also see our website: pbio.cfel.de - *Understanding enzyme catalysis by filming enzymes at atomic/fs resolution* Postdoctoral Position Center for Free Electron Laser Science (CFEL), Hamburg, Germany Enzymes are the best performing catalysts on Earth, yet the details of their function — for example what role dynamics play or not in chemical rearrangements — remain a source of debate. New x-ray free electron laser (XFEL) technology allows us to directly image proteins at the time and length-scales (atoms/fs) on which chemistry occurs, making it possible to directly study enzyme catalyzed reactions via imaging. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate to conduct this work on naturally occurring and man-made photoenzyme systems. As the ideal candidate, you will have the following key attributes: -- A doctoral degree in physics, chemistry, biochemistry, or a related field -- Excellent wet-lab skills, with knowledge of how to produce, purify, and crystallize proteins -- A basic familiarity with serial femtosecond crystallography and XFELs -- Basic computational skills including unix-style environments, python/matlab/similar -- The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: -- Design of experiments, including new hardware and software when necessary -- Organizing and leading teams of 2-20 people to conduct XFEL experiments -- Preparation of protein crystal samples and wet lab bio/chemistry -- Interpretation and analysis of experimental results -- Helping to foster an environment conducive to collaboration, learning, growth, and fun The position offers a chance to work at a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do g
