[ccp4bb] PDRA: Electron and X-ray crystallography of protein nanocrystals - Diamond Light Source

[Warren, Anna (DLSLtd,RAL,LSCI)]

Dear all,


We have an exciting opportunity within the MX group at Diamond Light Source for 
a highly motivated PDRA to carry out their own innovative research in the 
development of new methods and their application to structure determination by 
electron and X-ray diffraction of protein nanocrystals. The post will work 
within the HeXI/VMXm teams to understand the complementarity between X-ray and 
electron diffraction data. The role will include sample preparation, data 
collection and analysis on the VMXm beamline and the Diamond suite of electron 
microscopes where novel applications of serial and precession diffraction will 
be investigated. As the first-of-a-kind HeXI instrument is constructed, the 
post will also assist with commissioning the beamline and performing 
proof-of-concept electron diffraction experiments.



The successful applicant will benefit from Diamond's outstanding expertise and 
experience with data collection and data processing within the MX group along 
with the extensive specific expertise in the collection and processing of 
electron diffraction data within the eBIC and DIALS groups. A broad range of 
world-class instrumentation will be available to the PDRA including the MX 
beamlines and the electron microscopes at eBIC.

There will also be the opportunity to play an active role in interacting and 
collaborating with the extensive MX, chemical crystallography, and rapidly 
expanding EM communities based at Harwell such as ePSIC, The Research Complex, 
and The Rosalind Franklin Institute.

Please feel free to contact me with informal enquiries and see here for further 
details:

https://vacancies.diamond.ac.uk/vacancy/pdra-electron-and-xray-crystallography-of-protein-nanocrystals-550623.html

Best wishes,

Anna


Dr Anna Warren
Senior Beamline Scientist, VMXm
Micro/Nanofocus Macromolecular Crystallography Beamline
Diamond Light Source
Telephone: +44 (0)1235 567455
anna.war...@diamond.ac.uk


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[ccp4bb] CCP4 Study Weekend 2023 - Early bird registration ends 13th November

[Warren, Anna (DLSLtd,RAL,LSCI)]

This year the CCP4 Study Weekend will be held as a hybrid event from the 4th - 
6th January at the East Midlands Conference Centre, Nottingham, UK, with an 
exciting programme confirmed below. Early bird registration is open until 13th 
November, more details of which can be found here: 
https://ccp4sw.org/
With an exciting list of confirmed speakers, the event looks to be a great 
conference, with a topic based around "Data: subtle details to big insights". 
With a break from tradition, the Study Weekend will start with a keynote 
lecture and discussion panel talking and engaging with the audience about data 
sources and the future of structural biology. The subsequent 2 days will follow 
the usual format with 3 sessions each day.  Old favourites like "What's New in 
CCP4?" and "Lunchtime Bytes" will also appear (see 
programme for more details).
A poster session, with prizes, will be taking place this time on the evening of 
the first day allowing students to present their research to the wider 
crystallographic community. Student bursaries 
are available to cover the cost of registration and one night's accommodation. 
Student registration needs to be received before 13th November to take 
advantage of this.
In keeping with previous CCP4 meetings, the lectures will focus on the 
presentation and discussion of advanced methods and techniques developed and 
used by leaders in the field, whilst having a strong teaching element aimed at 
students and early researchers.

Sessions and confirmed speakers are as follows:

Day 1
Diamond MX User Meeting
Session 1: Integrative structural biology
Linking structural biology data sources to tackle Alzheimer's - Monserrat 
Soler-Lopez
Where do we see structural biology heading in the future? Discussion panel
Gerard Bricogne, Sameer Velanker, Loes Kroon-Batenburg, Jim Naismith, Kristina 
Djinovic-Carugo, Annalisa Pastore, Dave Stuart

Day 2
Session 2: Fundamentals of crystallographic data
Aimed at covering the fundamentals of what data is and what we do with it.
Graeme Winter, Greta M. Assman, Kavin Dalton, Richard Gildea
Session 3: Fundamentals of samples and the experiment
Ensuring we get the best from our data by optimising sample preparation and the 
experiment and looking at complementary techniques.
Ralf Flaig, Kathryn Shelley, Maria Garcia, Phillippe Carpentier
Session 4: Choosing your source
Understanding the source and experiment types to better answer your biological 
question.
Meytal Landau, Antoine Royant, Arnaud Basle, Hongyi Xu

Day 3
Session 5: Big data
Learning the complexities of handling larger datasets for a variety of 
experiment types.
Derek Mendez, Marjan Hadian-Jazi, Briony Yorke, Kyle Morris
Session 6: Between the Bragg spots
Understanding your data and trying to get the most out of it.
Gloria Borgstahl, Andrey Lebedev, Steve Meisburger
Session 7: A new era in Structural Biology
Exploring possible future directions for structural biology.
Dan Rigden, Sylvain Engilberge, Isabel Uson, Anastassis Perrakis

We look forward to seeing you all there and having some insightful discussions.
Christoph Mueller-Dieckmann (ESRF, France)
Anna Warren (Diamond Light Source)
David Waterman (UKRI-STFC CCP4)
Scientific Organisers






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This e-mail and any attachments may contain confidential, copyright and or 
privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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