*Merck* is a global health care leader with a diversified portfolio of
prescription medicines, vaccines and consumer health products, as well as
animal health products. Today, we are building a new kind of healthcare
company - one that is ready to help create a healthier future for all of
us.
Our ability to excel depends on the integrity, knowledge, imagination,
skill, diversity and teamwork of people like you. To this end, we strive to
create an environment of mutual respect, encouragement and teamwork. As
part of our global team, you'll have the opportunity to collaborate with
talented and dedicated colleagues while developing and expanding your
career.
This exciting position within Merck's Structural Chemistry group will
support drug lead discovery and optimization through the determination of
the X-ray structures of therapeutically important proteins. The successful
candidate will perform crystallization, crystal optimization, and structure
determination of protein-ligand complexes and will work in collaboration
with medicinal and computational chemists. The successful candidate will
also work closely with molecular biologists and protein biochemists and
will have access to automated cloning, expression, and crystallization
technologies.
*Sr. Scientist, Chemistry West Point, PA Job # CHE003955*
Productive and collaborative interactions with other members of the global,
cross-functional department are a must. Cooperative and collaborative use
of internal expertise will be essential to success. The position requires
active interaction with the scientific community to continually improve
scientific understanding, including presentations at national or
international meetings.
*Qualifications:*
- PhD degree with 2- 3 years postdoctoral training in membrane protein
crystallography.
- Demonstrated capability to design and execute X-ray crystallographic
structure determination using all modern techniques, including molecular
replacement and experimental phasing.
- Demonstrated potential to develop project management skills and
identify/develop new areas of scientific expertise in protein
crystallography.
- Excellent communication skills (written, presentation, and oral) that
enhance team-based progress is required. Application of those skills both
within and outside the department to ensure the maximum understanding of
program status for therapeutic area project teams and management is
required.
- Ability to work effectively within timelines.
- Ability to prepare peer-reviewed publications.
PREFERRED SKILLS:
- State-of-the-art knowledge of GPCR structural biology techniques
including all aspects of GPCR construct design, expression, solubilization,
purification, crystallization screening/optimization (including LCP and
LCP-FRAP), and structure determination/analysis a significant plus.
- Experience in the application of biophysical and functional
characterization methods (e.g., protein NMR, Biacore, Thermofluor, ligand
binding and receptor modality) to guide protein construct optimization for
crystallography is a plus.
Our employees are the key to our company's success. We demonstrate our
commitment to our employees by offering a competitive and valuable rewards
program. Merck's benefits are designed to support the wide range of goals,
needs and lifestyles of our employees, and many of the people that matter
the most in their lives.
To be considered for this position, please visit:
http://jobs.merck.com/job/West-Point-Sr_-Scientist%2C-GSC%2C-Chemistry-Job-PA-19486/29518900/
Merck is an equal opportunity employer, M/F/D/V - proudly embracing
diversity in all of its manifestations.
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