*Sr. Scientist, Chemistry*
*Merck* is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. This exciting position within Merck's Structural Chemistry group will support drug lead discovery and optimization through the determination of the X-ray structures of therapeutically important proteins. The successful candidate will perform crystallization, crystal optimization, and structure determination of protein-ligand complexes and will work in collaboration with medicinal and computational chemists. The successful candidate will also work closely with molecular biologists and protein biochemists and will have access to automated cloning, expression, and crystallization technologies. *Sr. Scientist, Chemistry West Point, PA Job # CHE003955* Productive and collaborative interactions with other members of the global, cross-functional department are a must. Cooperative and collaborative use of internal expertise will be essential to success. The position requires active interaction with the scientific community to continually improve scientific understanding, including presentations at national or international meetings. The specific responsibilities of the candidate include but are not limited to: - Design, conduct, interpret and report in vitro and/or in vivo immunology studies using a wide range of established methodologies. - Ensure data generated is communicated in a concise, easy to understand manner to the appropriate teams and stakeholders. Develop new methods and protocols de novo when and where needed. Monitor, review and critically interpret published work to guide internal research. - Actively contribute scientifically to immunological drug discovery research programs, including identification and validation of novel targets. - Collaborate with members from other functional groups, including medicinal chemistry, in vivo and in vitro pharmacology and translational sciences. - Work with external academic, biotechnology, and contract research organizations. - Mentor and guide other scientists in the group. Note: There are 3 positions available. *Qualifications:* - PhD degree with 2- 3 years postdoctoral training in membrane protein crystallography. - Demonstrated capability to design and execute X-ray crystallographic structure determination using all modern techniques, including molecular replacement and experimental phasing. - Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in protein crystallography. - Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required. - Ability to work effectively within timelines. - Ability to prepare peer-reviewed publications. PREFERRED SKILLS: - State-of-the-art knowledge of GPCR structural biology techniques including all aspects of GPCR construct design, expression, solubilization, purification, crystallization screening/optimization (including LCP and LCP-FRAP), and structure determination/analysis a significant plus. - Experience in the application of biophysical and functional characterization methods (e.g., protein NMR, Biacore, Thermofluor, ligand binding and receptor modality) to guide protein construct optimization for crystallography is a plus. Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. To be considered for this position, please visit: https://merck.taleo.net/careersection/ext_merckunitedstates_en/jobdetail.ftl Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service.
