The Graille lab is interested in understanding how epitranscritomic marks are deposited on RNAs and influence RNA translation and decay as well as cell proliferation and organ development. We currently use a combination of various experimental approaches : molecular biology, biochemistry, cell biology and structural biology. We are willing to develop cryo-EM studies on human ribosomes as well as on complexes between RNA modifying enzymes and their substrates. The lab has access to an in-house cryo-EM platform equipped with a LEICA EM-GP sampler plunger to prepare grids and a Titan THEMIS cryo-electron microscope (200 kV). Access to Titan KRIOS machines is possible on French or European facilities.
This project will be realized at the Laboratory of Structural Biology of the Cell (BIOC) from Ecole Polytechnique (Institut Polytechnique de Paris - IPP; Palaiseau; France), a leading French institute that combines top-level research, academics, and innovation at the cutting-edge of science and technology. The laboratory is located 40 minutes by train from Paris City centre. The campus offers all the equipments to perform various activities (music, theater…) or sports: swimming pools, 8 tennis courts, several football, badminton, tennis table, volleyball and basketball pitches, climbing walls, … The lab is looking for a candidate with solid knowledge in cryo-EM. The successful candidate will work in close collaboration with the team of Dr Schmitt and Mechulam, who have developed a strong expertise in cryo-EM since more than ten years. The selected candidate will apply to various local (Institut Polytechnique de Paris), national (charities such as FRM) or international (EMBO, Marie Curie, …) calls to get a post-doctoral fellowships to join the lab. The applicants should be preparing or hold a PhD degree with demonstrated knowledge in cryo-EM analysis of macromolecular complexes. Planned start date : Spring 2024. Working knowledge of the English language (scientific, oral and written) is necessary, but knowledge of French is not required as the team regularly hosts people from different countries. Enthusiasm, motivation and willingness to contribute to a dynamic and enjoyable working environment are very important qualities. The candidate should show autonomy, but a successful integration into the team projects is essential. Applications (including a detailed CV, summary of your current project and relevant skills and a contact information of two/three references) or information requests should be sent to Marc Graille (marc.grai...@polytechnique.edu). Website: http://bioc.polytechnique.fr/spip.php?rubrique117&lang=en <http://bioc.polytechnique.fr/spip.php?rubrique117&lang=en> Twitter : @GrailleLab — Marc GRAILLE, PhD DR1-CNRS Laboratoire de Biologie Structurale de la Cellule (BIOC; Ex-Laboratoire de Biochimie) UMR7654 du CNRS Head of the team: “Translation and degradation of eukaryotic mRNAs” ÉCOLE POLYTECHNIQUE 91128 PALAISEAU CEDEX FRANCE 📞: +33 (0)1 69 33 48 90 : marc.grai...@polytechnique.edu <mailto:marc.grai...@polytechnique.edu> / Twitter : @GrailleLab <https://twitter.com/GrailleLab> https://portail.polytechnique.edu/bioc/en/research/coupling-between-translation-and-mrna-degradation-eukaryotes — ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
