We are now seeking a highly experienced membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts.
At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants should possess a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals. This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company. The successful candidate is expected to: • Express and purify membrane proteins • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists • Prepare and effectively present results (written and oral) to project teams • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements: The preferred candidate will have the following: • Candidates should possess a PhD in biochemistry, biophysics or a related discipline • Candidates should have experience in membrane protein expression, purification and characterisation in either an academic or industry setting • Possess extensive molecular biology skills • Knowledgeable in prokaryotic and eukaryotic expression vectors and be experienced in their manipulation • Well-versed in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies • Expert in the expression of membrane proteins from mammalian and insect cells • Proficient in the purification and extensive biochemical characterisation of membrane proteins • Experienced in the reconstitution of purified membrane proteins in membrane-mimetic environments • Familiar with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques • Candidates should understand the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) • Candidates should be highly organised Other information The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2021-2BMS. The closing date for applications is 30th March 2021. Strictly no agencies ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
