[ccp4bb] postdoc position at Imperial College London

[Bubeck, Doryen A]

Dear All,

The Bubeck laboratory (https://www.imperial.ac.uk/people/d.bubeck) at Imperial 
College London, is looking to recruit a Research Associate with high level of 
expertise in cellular tomography. Additional expertise in microbiology is very 
suited for the position.

This post, funded by a highly competitive Wellcome Trust Investigator Award, 
aims to uncover how the membrane attack complex (MAC) kills bacterial 
pathogens. The project’s primary objective is to discover 1) where MAC is 
located within the bacterial envelope and 2) how does MAC activation control 
bacterial killing. The postholder will join an exciting interdisciplinary team 
of structural biologists and membrane biophysicists to tackle a major question 
in understanding host-pathogen interactions. The project focuses on cryo 
electron tomography-based studies of MAC within the context of a series of 
model membrane systems. The research builds on the lab’s strong track-record in 
complement structural biology and is closely linked with research activities in 
membrane biophysics with Prof. Prof. Mark Wallace at King’s College London. 
Imperial has access to an in-house Glacios XFEG equipped with a Falcon4 DED and 
Selectris X energy filter and has access to Titan Krios instruments through the 
London Cryo EM consortium (LonCEM) and UK national facilities (eBIC) at Diamond 
Light Source. The project will also benefit from new high-end computing 
infrastructure funded by the BBSRC that is designated for structural biology 
research.

See the full job ad and how to apply at:

https://www.imperial.ac.uk/jobs/search-jobs/description/index.php?jobId=20731&jobTitle=Research+Associate+in+Structural+Biology

Best wishes,

Doryen

___

Prof. Doryen Bubeck
Director Centre for Structural Biology
Department of Life Sciences
Imperial College London

https://www.imperial.ac.uk/people/d.bubeck
@bubecklab



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[ccp4bb] Postdoc position at Imperial College, London

[Low, Harry H]

Dear all,
A postdoctoral position is available in the lab focussed on understanding the 
role and mechanism of ESCRT-III-like membrane remodelling proteins in bacteria 
(for example https://pubmed.ncbi.nlm.nih.gov/34166615/). Core techniques will 
include cryoEM SPA and tomography. The position is funded by the BBSRC and is 
available for four years.

For further details please see 
https://www.imperial.ac.uk/jobs/description/MED03064/research-associate or 
contact Harry Low informally h@imperial.ac.uk. 
The lab webpage can be found at www.thelowlab.org.

The closing date for applications is 21st April 2022.

Regards,
Harry







__
Dr. Harry Low
Wellcome Trust Senior Research Fellow
Department of Infectious Disease
366 Sir Alexander Fleming Building
Imperial College
London, SW7 2AZ
+44 207 594 3064




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[ccp4bb] Postdoc position at Imperial College London

[Bubeck, Doryen A]

Dear all,

I wanted to call your attention to an exciting job opportunity that integrates 
cryoEM and membrane biophysics to understand how the immune system fights 
infection. The position is funded by a Wellcome Trust Investigator Award in the 
labs of Doryen Bubeck (Imperial College London) and Mark Wallace (Kings College 
London). Please see below for details on the position and how to apply.

Best wishes,

Doryen Bubeck

_

Dr. Doryen Bubeck
Director Centre for Structural Biology
Department of Life Sciences
Imperial College London

https://www.imperial.ac.uk/people/d.bubeck
@bubecklab


Job Summary

The Bubeck laboratory (https://www.imperial.ac.uk/people/d.bubeck) is looking 
to recruit a Research Associate with high level of expertise in cellular 
tomography. Additional expertise in microbiology is very suited for the 
position.

Duties and responsibilities

This post, funded by a highly competitive Wellcome Trust Investigator Award, 
aims to uncover how the membrane attack complex (MAC) kills bacterial 
pathogens. The project’s primary objective is to discover 1) where MAC is 
located within the bacterial envelope and 2) how does MAC activation control 
bacterial killing. You will join an exciting interdisciplinary team of 
structural biologists and membrane biophysicists to tackle a major question in 
understanding host-pathogen interactions. The project focuses on cryo electron 
tomography-based studies of MAC within the context of a series of model 
membrane systems. The research builds on the lab’s strong track-record in 
complement structural biology and is closely linked with research activities in 
membrane biophysics with Prof. Mark Wallace 
 at King’s College London.

Essential requirements

You will have a PhD (or be near completion of) in structural biology, ideally 
with experience in cellular tomography. You must have a strong research track 
record in studying protein-protein and protein-membrane complexes preferably 
demonstrated by first author publications in international journals. Experience 
in the design and execution of workflow for structure determination of proteins 
or cellular systems from sample preparation to acquisition and analysis of 
structural biology data.

You must have excellent verbal and written communication skills, and be able to 
write clearly and succinctly for publication. You must also be able to relate 
well with others, form positive relationships with a wide range of people and 
to work as part of a team, as well as independently. The ability to develop and 
apply new concepts and have a creative approach to problem-solving, to set and 
attain research objectives in a multidisciplinary team are also essential.

Further Information

This is a full-time, fixed-term appointment available for up to three years, 
with the possibility of extension. You will be based at South Kensington Campus.

Candidates who have not yet been officially awarded their PhD will be appointed 
as Research Assistant within the salary range, £36,694- £39,888 per annum.

Informal enquiries to Dr. Doryen Bubeck: 
d.bub...@imperial.ac.uk

Closing date is 30 March 2022.

To apply 
https://www.imperial.ac.uk/jobs/description/NAT01088/research-associate-structural-biology



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[ccp4bb] postdoc position at Imperial College London

[Zhang, Xiaodong]

Dear all

There is a postdoc position available in my lab. For details and how to apply, 
please follow this link.

https://www.imperial.ac.uk/jobs/description/MED02162/research-associate-structural-biology

kind regards

Prof Xiaodong Zhang, Section of Structural Biology, Department of Infectious 
Disease, Imperial College London
Room 104, Sir Alexander Fleming Building, South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk, (0) 207 
594 3151, http://www.imperial.ac.uk/people/xiaodong.zhang

PA - Ms Kasia Pearce, 
structuralbiolog...@imperial.ac.uk, 
(0) 207 594 2917





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[ccp4bb] Postdoc position at Imperial College London

[Zhang, Xiaodong]

Dear all,

There is a postdoc position available in my group 
(https://www.imperial.ac.uk/people/xiaodong.zhang). The successful candidate 
will join a multi-disciplinary team of international researchers investigating 
the structures and mechanisms of key components involved in eukaryotic DNA 
damage signalling and repair. We employ a combination of cryo electron 
microscopy, X-ray crystallography, biochemical and biophysical techniques, 
utilising our excellent structural biology facilities at Imperial College 
London.

Details about this post and how to apply can be found 
http://www.imperial.ac.uk/jobs/description/MED02162/research-associate-structural-biology

For informal enquiries, please email me directly with your CV.

with best wishes

Xiaodong

Professor Xiaodong Zhang
Section of Structural Biology, Department of Infectious Diseases, Imperial 
College London
104, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, +44 207 
594 3151, PA: Ms. Kasia Pearce 
(k.pea...@imperial.ac.uk). 0207 594 2763
www.imperial.ac.uk/people/xiaodong.zhang






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[ccp4bb] Postdoc position at Imperial College London

[Ali, Maruf]

Dear All

A quick reminder of a job opening for a postdoc researcher to join my group at 
Imperial College.  The closing date for applications is 18th Sept 2019.

The research project focuses on determining the structure and mechanism of ER 
chaperone complexes involved in stress signaling/unfolded protein response and 
protein homeostasis.  Methodology will include cryo-electron microscopy (EM) 
and a suite of biophysical, biochemical and cellular assays to determine 
structure and function.

Please see 
https://www.imperial.ac.uk/jobs/description/NAT00509/research-associate/ for 
further information.

all the best
Maruf

Senior Cancer Research UK Fellow
RM 505 Sir Ernst Chain Building
Department of Life Sciences
Imperial College
London SW7 2AZ
Tel: 0207 594 5733




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[ccp4bb] Postdoc Position at Imperial College London

[Zhang, Xiaodong]

Dear all,

We invite enthusiastic individuals to apply for a Research Association position 
in the group of Xiaodong Zhang (https://www.structurebiomed.org), within the 
Section of Structural 
Biology,
 Department of Medicine, at Imperial College London’s South Kensington Campus.

The successful candidate will join a multi-disciplinary team of international 
researchers investigating the structures and mechanisms of bacterial 
transcription regulation and signal transduction by AAA ATPases. We employ a 
combination of Biochemistry, cryo electron microscopy and X-ray 
crystallography, utilizing our excellent protein production and structural 
biology facilities at Imperial.

We welcome individuals with a PhD (or about to obtain one) in structural 
biology, biochemistry or biophysics with a strong interest in 
inter-disciplinary structural molecular biology research.

The post is full-time, fixed-term until 30 September 2022.

Application deadline: July 2nd, 2018

For details and application procedure, please visit 
https://www.imperial.ac.uk/jobs/description/MED00558/research-associate

 For informal enquiries, please contact: 
xiaodong.zh...@imperial.ac.uk

Prof Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

Room 104, Sir Alexander Fleming Building
South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang
(0) 207 594 3151

PA - Ms Sorina Damsa, structuralbiolog...@imperial.ac.uk, (0) 207 594 2917




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[ccp4bb] postdoc position at Imperial College London

[Zhang, Xiaodong]

We wish to recruit a Research Associate to work with Professor Xiaodong Zhang’s 
research team in the Division of Molecular Biosciences, Centre for Structural 
Biology, at the South Kensington Campus of Imperial College London. This 
project is led by Prof. Xiaodong Zhang 
(http://www3.imperial.ac.uk/people/xiaodong.zhang)  in collaboration with Prof. 
Dale Wigley, Institute of Cancer Research.
Eukaryotic genomic DNA is organized into nucleosomes and chromatin for genome 
stability and integrity. However, this creates barriers for processes that 
require access to the DNA, such as transcription and DNA repair.  Chromatin 
remodeling complexes remodel nucleosomes and chromatin to provide access.  The 
INO80 complex is a multi-subunit, large macromolecular machine that remodels 
nucleosomes upon DNA damage in order for the repair machinery to access the 
damaged DNA. We are currently conducting an exciting and comprehensive study on 
the structure and mechanism of the INO80 complex using a combination of protein 
biochemistry, X-ray crystallography and electron microscopy techniques. The 
successful candidate will join a team of scientists with diverse backgrounds 
and will be responsible for carrying out structural studies of the INO80 
complex, primarily using electron microscopy techniques. The successful 
candidate will work closely with Prof. Wigley’s laboratory at the Institute of 
Cancer Research, Chester Beatty Laboratories where the majority of the protein 
biochemistry will be carried out.
Successful candidates must hold a PhD in a structural biology or biochemistry 
discipline and have demonstrated an ability to carry out high quality original 
research using electron microscopy techniques.

Salary  will be in the range of  £31,300 – £33,020 per annum.

This position is funded for 3 years by the Wellcome Trust and is available from 
January 1 2012 onwards.
Closing date – November 10, 2011
Please apply online 
http://www3.imperial.ac.uk/employment/applicationforms/researcherapp
and quote reference  NS 2011 187 KT

Professor Xiaodong Zhang
Imperial College London
Division of Molecular Biosciences
504, Wolfson laboratories
South Kensington, London, SW7 2AZ
(0) 207 594 3151
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang

[ccp4bb] Postdoc position at Imperial College London ; X-ray protein crystallography of light induced reactions

[van Thor, Jasper]

Research Associate in X-ray protein crystallography of light induced reactions 

Employer:Imperial College London
Website:http://www.imperial.ac.uk/mol...
Location:Exhibition Road, South Kensington, London, SW7 2AZ
Posted:October 21, 2009
Expires:January 04, 2010
Requisition number: NS2009160AB 

Salary: £26,720 – £38,930 per annum

Fixed Term for 24 months

Applications are invited for a Research Associate position in the Division of 
Molecular Biosciences in the field of time resolved Laue X-ray crystallography 
of light sensitive proteins in the group of Dr. Jasper van Thor.

The successful candidate will develop and employ experiments for time resolved 
X-ray diffraction using the pink-Laue technique at specialised beam line 
stations that combine pulsed broadband hard X-rays with pulsed optical 
excitation, at the SLS, APS and ESRF. The post will be based at Imperial 
College London, South Kensington campus

The work will be conducted in a multidisciplinary environment which includes 
facilities for ultrafast electronic and vibrational spectroscopies to support 
the optical control of photolysis and reaction initiation in macromolecular 
crystals.

The research deals with the light induced reactions in photoreceptors and 
fluorescent proteins and will focus on crystallisation of existing and new 
targets, analysis and optimisation of Laue diffraction, data processing and 
structure calculation of sub-ns intermediates. The van Thor group also provides 
support for ultrafast spectroscopic investigation of light induced reactions in 
targets. You will be required to work with members of the team on spectroscopic 
characterisation and photolysis control.

You will have a PhD in a relevant discipline (e.g. biochemistry, chemistry or 
physics) or the equivalent professional qualifications and experience with a 
track record in Structural Biology. You will have extensive experience in 
monochromatic and/or Laue protein X-ray crystallography using synchrotron beam 
line stations or alternatively neutron diffraction.

You will also have experience in crystallographic data processing and structure 
calculation. Experience in biomolecular spectroscopy would be an advantage. 
Experience with molecular biology, protein purification and crystallisation 
will be desirable.

Our preferred method of application is online via our website 
http://www3.imperial.ac.uk/employment. Please complete and upload an 
application form as directed.

[ccp4bb] Postdoc position at Imperial College London

[P Freemont]

A Research Associate position in protein crystallography is available  
within the group of Prof. Paul Freemont  (Division of Molecular  
Biosciences, Imperial College London: www.imperial.ac.uk/molecularbiosciences) 
 as part of the Imperial College Small Molecule Cancer Drug Discovery  
Programme funded by CRUK and is available immediately for a period of  
3 years, with a possibility of renewal for a further 2 years (subject  
to funding).  The aim of the programme is to create a pipeline for  
small molecule anti-cancer drug discovery and development, using a  
chemistry-biology interface with protein crystallography to optimise  
lead compounds.  The overall goal of the programme is to develop and  
test novel anti-cancer compounds in humans  as led by clinicians in  
the Imperial College Cancer group at Hammersmith Hospital led by Prof.  
Charles Coombes.  The small molecule programme is highly focused and  
will require the appointed research associate to work on a variety of  
protein targets in collaboration with clinical scientists  as part of  
an interdisciplinary team that encompasses a major part of the drug  
discovery pipeline, including synthetic and medicinal chemistry, chemo- 
informatics, rational drug design, molecular and cell biology and  
clinical biochemistry.
The successful candidate will have a PhD or equivalent qualification  
in a relevant research area and previous research experience in  
structural biology using primarily protein crystallography.  The  
project will also require research experience and skills in  
recombinant protein expression, purification, crystallisation and  
small-ligand screening using protein crystallography and other  
biophysical methods.
Further details and an application form can be obtained from the  
College employment website: http://www3.imperial.ac.uk/employment/research 
.
Completed application forms accompanied by a curriculum vitae and the  
names and contact details of two referees should be sent to: Mrs Naomi  
Anderson-Eyles, Imperial College London, Room 503, Biochemistry  
Building, Exhibition Road, London, SW7 2AZ or by email to: [EMAIL PROTECTED]

 Closing date: 4 July 2008