[ccp4bb] data processing with split/bad crystals

[Kajander, Tommi A]

Dear All, 

I was wondering what would be the best software nowadays to try to process data 
from crystal that clearly is split or
has a secondary set of lattice points (close, poor data) in the raw data - data 
can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
bit high at low resolution (close to 7-8% depending on processing) - using 
XSCALE helps with the radiation damage correction some what. 

Data looks like primitive orthorombic but not quite sure (also seems like it 
has one screw axis e.g. P2212 - but oddly phaser finds 
solutions in P22121 also or even preferably…..). I am wondering a bit if it 
isn’t actually monoclinic. 

Based on automated processing by Diamond pipeline XDS seems most robust - but 
any hints on such cases would
be welcome. Of course we will try to get better crystal but so far no luck.

Thanks for comments,

Best
Tommi



---

Tommi Kajander, Ph.D.
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland





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Re: [ccp4bb] data processing with split/bad crystals

[Tim Gruene]

Dear Tommi,

saint (Part of the Bruker APEX/Proteum suite) can integrate with, I think, up 
to five orientation matrices at a time. It integrates smoothly with twinabs. 
Saint seems quite sophisticated in modelling the reflection profiles from the 
different lattices.
EvalCCD (Eval15?) may be able to to similar things.

Other packages can integrate different lattices one after the other (XDS can 
do this with little effort), but they don't take into account that spots may 
be the result of overlapping reflections from different lattices.

You can check your next Chemistry department. Chances they have an APEX 
installation are quite high.

Best,
Tim

On Monday, July 16, 2018 10:55:15 PM CEST Kajander, Tommi A wrote:
> Dear All, 
> 
> I was wondering what would be the best software nowadays to try to process
> data from crystal that clearly is split or
 has a secondary set of lattice
> points (close, poor data) in the raw data - data can be processed with XDS
> (2.9-2.8 Å) but Rmerge tends to be bit high at low resolution (close to
> 7-8% depending on processing) - using XSCALE helps with the radiation
> damage correction some what. 
> Data looks like primitive orthorombic but not quite sure (also seems like it
> has one screw axis e.g. P2212 - but oddly phaser finds 
 solutions in
> P22121 also or even preferably…..). I am wondering a bit if it isn’t
> actually monoclinic. 
> Based on automated processing by Diamond pipeline XDS seems most robust -
> but any hints on such cases would
 be welcome. Of course we will try to get
> better crystal but so far no luck. 
> Thanks for comments,
> 
> Best
> Tommi
> 
> 
> 
> ---
> 
> Tommi Kajander, Ph.D.
> Structural Biology and Biophysics
> Institute of Biotechnology
> University of Helsinki
> Viikinkaari 1 (P.O. Box 65)
> 00014 Helsinki, Finland
> 
> 
> 
> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1

-- 
--
Paul Scherrer Institut
Tim Gruene
- persoenlich -
OSUA/204
CH-5232 Villigen PSI
phone: +41 (0)56 310 5297

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Re: [ccp4bb] data processing with split/bad crystals

[Andreas Förster]

Dear Tommi,

DIALS is good with multiple lattices.  It might not have given you best 
results as part of the Diamond pipeline, but give it a try with the 
max_lattices=2 parameter during dials.index and see where it takes you.


That said, you'll end up with worse statistics if you have two lattices. 
 Don't expect magic from your processing programs.


All best.


Andreas



On 16/07/2018 10:55, Kajander, Tommi A wrote:

Dear All,

I was wondering what would be the best software nowadays to try to process data 
from crystal that clearly is split or
has a secondary set of lattice points (close, poor data) in the raw data - data 
can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
bit high at low resolution (close to 7-8% depending on processing) - using 
XSCALE helps with the radiation damage correction some what.

Data looks like primitive orthorombic but not quite sure (also seems like it 
has one screw axis e.g. P2212 - but oddly phaser finds
solutions in P22121 also or even preferably…..). I am wondering a bit if it 
isn’t actually monoclinic.

Based on automated processing by Diamond pipeline XDS seems most robust - but 
any hints on such cases would
be welcome. Of course we will try to get better crystal but so far no luck.

Thanks for comments,

Best
Tommi



---

Tommi Kajander, Ph.D.
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland





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Re: [ccp4bb] data processing with split/bad crystals

[Rangana Warshamanage]

CrysAlisPro would be my best bet. It has an option for multicystals and
twinning. Also it offers a very good visual tools to see any relationships
between multiple lattices, if they have.

Rangana

On Mon, 16 Jul 2018 at 22:16 Andreas Förster  wrote:

> Dear Tommi,
>
> DIALS is good with multiple lattices.  It might not have given you best
> results as part of the Diamond pipeline, but give it a try with the
> max_lattices=2 parameter during dials.index and see where it takes you.
>
> That said, you'll end up with worse statistics if you have two lattices.
>   Don't expect magic from your processing programs.
>
> All best.
>
>
> Andreas
>
>
>
> On 16/07/2018 10:55, Kajander, Tommi A wrote:
> > Dear All,
> >
> > I was wondering what would be the best software nowadays to try to
> process data from crystal that clearly is split or
> > has a secondary set of lattice points (close, poor data) in the raw data
> - data can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
> > bit high at low resolution (close to 7-8% depending on processing) -
> using XSCALE helps with the radiation damage correction some what.
> >
> > Data looks like primitive orthorombic but not quite sure (also seems
> like it has one screw axis e.g. P2212 - but oddly phaser finds
> > solutions in P22121 also or even preferably…..). I am wondering a bit if
> it isn’t actually monoclinic.
> >
> > Based on automated processing by Diamond pipeline XDS seems most robust
> - but any hints on such cases would
> > be welcome. Of course we will try to get better crystal but so far no
> luck.
> >
> > Thanks for comments,
> >
> > Best
> > Tommi
> >
> >
> >
> > ---
> >
> > Tommi Kajander, Ph.D.
> > Structural Biology and Biophysics
> > Institute of Biot
> echnology
> > University of Helsinki
> > Viikinkaari 1 (P.O. Box 65)
> > 00014 Helsinki, Finland
> >
> >
> >
> > 
> >
> > To unsubscribe from the CCP4BB list, click the following link:
> > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
> >
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
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>



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Re: [ccp4bb] data processing with split/bad crystals

[graeme.win...@diamond.ac.uk]

Dear Andreas, all,


With DIALS, correct treatment of overlapping reflections is current work in 
progress - yes, you can index and refine two or more independent lattices, but 
running dials integration on this will probably not work as well as we'd like 
at the moment. It should do something sensible-ish but... Split lattices are 
tricky: at low angle the spots tend to overlap / merge, at higher angles become 
resolved, so treating them as independent lattices as Andreas describes may not 
be successful.


My experience of chemical crystallography at a synchrotron is that a large 
fraction of samples come with satellites etc, so developing robust handling for 
this is very much on our to-do and in current active development.


Of course, this is one of those data processing problems which is perhaps best 
fixed with a better sample 😉 but that's not a very helpful answer!


Best wishes Graeme



From: CCP4 bulletin board  on behalf of Andreas Förster 

Sent: 16 July 2018 22:14:49
To: ccp4bb
Subject: Re: [ccp4bb] data processing with split/bad crystals

Dear Tommi,

DIALS is good with multiple lattices.  It might not have given you best
results as part of the Diamond pipeline, but give it a try with the
max_lattices=2 parameter during dials.index and see where it takes you.

That said, you'll end up with worse statistics if you have two lattices.
  Don't expect magic from your processing programs.

All best.


Andreas



On 16/07/2018 10:55, Kajander, Tommi A wrote:
> Dear All,
>
> I was wondering what would be the best software nowadays to try to process 
> data from crystal that clearly is split or
> has a secondary set of lattice points (close, poor data) in the raw data - 
> data can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
> bit high at low resolution (close to 7-8% depending on processing) - using 
> XSCALE helps with the radiation damage correction some what.
>
> Data looks like primitive orthorombic but not quite sure (also seems like it 
> has one screw axis e.g. P2212 - but oddly phaser finds
> solutions in P22121 also or even preferably…..). I am wondering a bit if it 
> isn’t actually monoclinic.
>
> Based on automated processing by Diamond pipeline XDS seems most robust - but 
> any hints on such cases would
> be welcome. Of course we will try to get better crystal but so far no luck.
>
> Thanks for comments,
>
> Best
> Tommi
>
>
>
> ---
>
> Tommi Kajander, Ph.D.
> Structural Biology and Biophysics
> Institute of Biotechnology
> University of Helsinki
> Viikinkaari 1 (P.O. Box 65)
> 00014 Helsinki, Finland
>
>
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>



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Re: [ccp4bb] data processing with split/bad crystals

[CCP4BB]

Hi

And of course, Mosflm can also process (up to 10 if you really wanted to push 
it) multiple lattices; the feature is easily accessible from iMosflm (and the 
"QuickScale" option can merge the reflections appropriately). Overlapped 
reflections are "dealt with", but not as elegantly as some of the other 
programs like Eval 15 or Saint.

However, I'd apply all the caveats that other people have mentioned with regard 
to other programs. By far the best option is to collect data on a single 
crystal - but that's only best if you have access to one...

Harry
--
Dr Harry Powell
Chairman of European Crystallographic Association SIG9 (Crystallographic 
Computing) 

> On 17 Jul 2018, at 05:40, graeme.win...@diamond.ac.uk 
>  wrote:
> 
> Dear Andreas, all,
> 
> 
> With DIALS, correct treatment of overlapping reflections is current work in 
> progress - yes, you can index and refine two or more independent lattices, 
> but running dials integration on this will probably not work as well as we'd 
> like at the moment. It should do something sensible-ish but... Split lattices 
> are tricky: at low angle the spots tend to overlap / merge, at higher angles 
> become resolved, so treating them as independent lattices as Andreas 
> describes may not be successful.
> 
> 
> My experience of chemical crystallography at a synchrotron is that a large 
> fraction of samples come with satellites etc, so developing robust handling 
> for this is very much on our to-do and in current active development.
> 
> 
> Of course, this is one of those data processing problems which is perhaps 
> best fixed with a better sample 😉 but that's not a very helpful answer!
> 
> 
> Best wishes Graeme
> 
> 
> ____
> From: CCP4 bulletin board  on behalf of Andreas 
> Förster 
> Sent: 16 July 2018 22:14:49
> To: ccp4bb
> Subject: Re: [ccp4bb] data processing with split/bad crystals
> 
> Dear Tommi,
> 
> DIALS is good with multiple lattices.  It might not have given you best
> results as part of the Diamond pipeline, but give it a try with the
> max_lattices=2 parameter during dials.index and see where it takes you.
> 
> That said, you'll end up with worse statistics if you have two lattices.
>  Don't expect magic from your processing programs.
> 
> All best.
> 
> 
> Andreas
> 
> 
> 
>> On 16/07/2018 10:55, Kajander, Tommi A wrote:
>> Dear All,
>> 
>> I was wondering what would be the best software nowadays to try to process 
>> data from crystal that clearly is split or
>> has a secondary set of lattice points (close, poor data) in the raw data - 
>> data can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
>> bit high at low resolution (close to 7-8% depending on processing) - using 
>> XSCALE helps with the radiation damage correction some what.
>> 
>> Data looks like primitive orthorombic but not quite sure (also seems like it 
>> has one screw axis e.g. P2212 - but oddly phaser finds
>> solutions in P22121 also or even preferably…..). I am wondering a bit if it 
>> isn’t actually monoclinic.
>> 
>> Based on automated processing by Diamond pipeline XDS seems most robust - 
>> but any hints on such cases would
>> be welcome. Of course we will try to get better crystal but so far no luck.
>> 
>> Thanks for comments,
>> 
>> Best
>> Tommi
>> 
>> 
>> 
>> ---
>> 
>> Tommi Kajander, Ph.D.
>> Structural Biology and Biophysics
>> Institute of Biotechnology
>> University of Helsinki
>> Viikinkaari 1 (P.O. Box 65)
>> 00014 Helsinki, Finland
>> 
>> 
>> 
>> 
>> 
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>> 
> 
> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
> 
> -- 
> This e-mail and any attachments may contain confidential, copyright and or 
> privileged material, and are for the use of the intended addressee only. If 
> you are not the intended addressee or an authorised recipient of the 
> addressee please notify us of receipt by returning the e-mail and do not use, 
> copy, retain, distribute or disclose the information in or attached to the 
> e-mail.
> Any opinions expressed within this e-mail are those of the individual and not 
> necessarily of Diam

Re: [ccp4bb] data processing with split/bad crystals

[Kroon-Batenburg, L.M.J. (Louise)]

Dear Tommi, 
You may want to try EVAL: www. cryst.chem.uu.nl/distr/eval
EVAL can deconvolute reflections from multiple lattices.

Best wishes
Loes

___

Dr. Loes Kroon-Batenburg

Dept. of Crystal and Structural Chemistry
Bijvoet Center for Biomolecular Research
Utrecht University
Padualaan 8, 3584 CH Utrecht
The Netherlands

E-mail : l.m.j.kroon-batenb...@uu.nl
phone  : +31-30-2532865
fax: +31-30-2533940


From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] on behalf of Kajander, Tommi 
A [tommi.kajan...@helsinki.fi]
Sent: Monday, July 16, 2018 10:55 PM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] data processing with split/bad crystals

Dear All,

I was wondering what would be the best software nowadays to try to process data 
from crystal that clearly is split or
has a secondary set of lattice points (close, poor data) in the raw data - data 
can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
bit high at low resolution (close to 7-8% depending on processing) - using 
XSCALE helps with the radiation damage correction some what.

Data looks like primitive orthorombic but not quite sure (also seems like it 
has one screw axis e.g. P2212 - but oddly phaser finds
solutions in P22121 also or even preferably…..). I am wondering a bit if it 
isn’t actually monoclinic.

Based on automated processing by Diamond pipeline XDS seems most robust - but 
any hints on such cases would
be welcome. Of course we will try to get better crystal but so far no luck.

Thanks for comments,

Best
Tommi



---

Tommi Kajander, Ph.D.
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland





To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1



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Re: [ccp4bb] data processing with split/bad crystals

[Murpholino Peligro]

Link provided not working. Need the http prefix, like this
http://www.crystal.chem.uu.nl/distr/eval/

El mar., 17 de jul. de 2018 a la(s) 11:24, Kroon-Batenburg, L.M.J. (Louise)
(l.m.j.kroon-batenb...@uu.nl) escribió:

> Dear Tommi,
> You may want to try EVAL: www. cryst.chem.uu.nl/distr/eval
> EVAL can deconvolute reflections from multiple lattices.
>
> Best wishes
> Loes
>
> ___
>
> Dr. Loes Kroon-Batenburg
>
> Dept. of Crystal and Structural Chemistry
> Bijvoet Center for Biomolecular Research
> Utrecht University
> Padualaan 8, 3584 CH Utrecht
> The Netherlands
>
> E-mail : l.m.j.kroon-batenb...@uu.nl
> phone  : +31-30-2532865
> fax: +31-30-2533940
>
> 
> From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] on behalf of Kajander,
> Tommi A [tommi.kajan...@helsinki.fi]
> Sent: Monday, July 16, 2018 10:55 PM
> To: CCP4BB@JISCMAIL.AC.UK
> Subject: [ccp4bb] data processing with split/bad crystals
>
> Dear All,
>
> I was wondering what would be the best software nowadays to try to process
> data from crystal that clearly is split or
> has a secondary set of lattice points (close, poor data) in the raw data -
> data can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
> bit high at low resolution (close to 7-8% depending on processing) - using
> XSCALE helps with the radiation damage correction some what.
>
> Data looks like primitive orthorombic but not quite sure (also seems like
> it has one screw axis e.g. P2212 - but oddly phaser finds
> solutions in P22121 also or even preferably…..). I am wondering a bit if
> it isn’t actually monoclinic.
>
> Based on automated processing by Diamond pipeline XDS seems most robust -
> but any hints on such cases would
> be welcome. Of course we will try to get better crystal but so far no luck.
>
> Thanks for comments,
>
> Best
> Tommi
>
>
>
> ---
>
> Tommi Kajander, Ph.D.
> Structural Biology and Biophysics
> Institute of Biotechnology
> University of Helsinki
> Viikinkaari 1 (P.O. Box 65)
> 00014 Helsinki, Finland
>
>
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>



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Re: [ccp4bb] data processing with split/bad crystals

[Kajander, Tommi A]

Thank you for the replies on this- i will report if we find a particular 
software to work better!

Best,
Tommi


On 17 Jul 2018, at 21:53, Murpholino Peligro 
mailto:murpholi...@gmail.com>> wrote:

Link provided not working. Need the http prefix, like this 
http://www.crystal.chem.uu.nl/distr/eval/

El mar., 17 de jul. de 2018 a la(s) 11:24, Kroon-Batenburg, L.M.J. (Louise) 
(l.m.j.kroon-batenb...@uu.nl<mailto:l.m.j.kroon-batenb...@uu.nl>) escribió:
Dear Tommi,
You may want to try EVAL: www. 
cryst.chem.uu.nl/distr/eval<http://cryst.chem.uu.nl/distr/eval>
EVAL can deconvolute reflections from multiple lattices.

Best wishes
Loes

___

Dr. Loes Kroon-Batenburg

Dept. of Crystal and Structural Chemistry
Bijvoet Center for Biomolecular Research
Utrecht University
Padualaan 8, 3584 CH Utrecht
The Netherlands

E-mail : l.m.j.kroon-batenb...@uu.nl<mailto:l.m.j.kroon-batenb...@uu.nl>
phone  : +31-30-2532865
fax: +31-30-2533940


From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>] 
on behalf of Kajander, Tommi A 
[tommi.kajan...@helsinki.fi<mailto:tommi.kajan...@helsinki.fi>]
Sent: Monday, July 16, 2018 10:55 PM
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp4bb] data processing with split/bad crystals

Dear All,

I was wondering what would be the best software nowadays to try to process data 
from crystal that clearly is split or
has a secondary set of lattice points (close, poor data) in the raw data - data 
can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
bit high at low resolution (close to 7-8% depending on processing) - using 
XSCALE helps with the radiation damage correction some what.

Data looks like primitive orthorombic but not quite sure (also seems like it 
has one screw axis e.g. P2212 - but oddly phaser finds
solutions in P22121 also or even preferably…..). I am wondering a bit if it 
isn’t actually monoclinic.

Based on automated processing by Diamond pipeline XDS seems most robust - but 
any hints on such cases would
be welcome. Of course we will try to get better crystal but so far no luck.

Thanks for comments,

Best
Tommi



---

Tommi Kajander, Ph.D.
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland





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Tommi Kajander, Ph.D., PI
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland
p. +358-2-941-58904 / +358-050-4480991
tommi.kajan...@helsinki.fi<mailto:tommi.kajan...@helsinki.fi>
http://www.biocenter.helsinki.fi/bi/kajander/






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Re: [ccp4bb] data processing with split/bad crystals

[Kajander, Tommi A]

Thank you for the replies on this- i will report if we find a particular 
software to work better!

Best,
Tommi


On 17 Jul 2018, at 21:53, Murpholino Peligro 
mailto:murpholi...@gmail.com>> wrote:

Link provided not working. Need the http prefix, like this 
http://www.crystal.chem.uu.nl/distr/eval/

El mar., 17 de jul. de 2018 a la(s) 11:24, Kroon-Batenburg, L.M.J. (Louise) 
(l.m.j.kroon-batenb...@uu.nl<mailto:l.m.j.kroon-batenb...@uu.nl>) escribió:
Dear Tommi,
You may want to try EVAL: www. 
cryst.chem.uu.nl/distr/eval<http://cryst.chem.uu.nl/distr/eval>
EVAL can deconvolute reflections from multiple lattices.

Best wishes
Loes

___

Dr. Loes Kroon-Batenburg

Dept. of Crystal and Structural Chemistry
Bijvoet Center for Biomolecular Research
Utrecht University
Padualaan 8, 3584 CH Utrecht
The Netherlands

E-mail : l.m.j.kroon-batenb...@uu.nl<mailto:l.m.j.kroon-batenb...@uu.nl>
phone  : +31-30-2532865
fax: +31-30-2533940


From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>] 
on behalf of Kajander, Tommi A 
[tommi.kajan...@helsinki.fi<mailto:tommi.kajan...@helsinki.fi>]
Sent: Monday, July 16, 2018 10:55 PM
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp4bb] data processing with split/bad crystals

Dear All,

I was wondering what would be the best software nowadays to try to process data 
from crystal that clearly is split or
has a secondary set of lattice points (close, poor data) in the raw data - data 
can be processed with XDS (2.9-2.8 Å) but Rmerge tends to be
bit high at low resolution (close to 7-8% depending on processing) - using 
XSCALE helps with the radiation damage correction some what.

Data looks like primitive orthorombic but not quite sure (also seems like it 
has one screw axis e.g. P2212 - but oddly phaser finds
solutions in P22121 also or even preferably…..). I am wondering a bit if it 
isn’t actually monoclinic.

Based on automated processing by Diamond pipeline XDS seems most robust - but 
any hints on such cases would
be welcome. Of course we will try to get better crystal but so far no luck.

Thanks for comments,

Best
Tommi



---

Tommi Kajander, Ph.D.
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland





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Tommi Kajander, Ph.D., PI
Structural Biology and Biophysics
Institute of Biotechnology
University of Helsinki
Viikinkaari 1 (P.O. Box 65)
00014 Helsinki, Finland
p. +358-2-941-58904 / +358-050-4480991
tommi.kajan...@helsinki.fi<mailto:tommi.kajan...@helsinki.fi>
http://www.biocenter.helsinki.fi/bi/kajander/






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