[CMLHope] Re: white skin
Hi Allyson, There are lots of medical reports on hypopigmentation on Gleevec, so it is a medical fact, a side-effect of Gleevec. Since you go to MDACC, you may be interested in a study by them, given below. But it is a well-known side-effect of Gleevec in Asia since the lightening of the skin in the patients is more apparent. The website below should give you information on how losing skin pigmentation may be harmful to you. Let me know if you have further questions. http://www.childrenshospital.org/az/Site1607/mainpageS1607P0.html They have even measured the loss of skin color in a Gleevec patient by colorimetric methods. Best Wishes, Anjana caregiver to Roy Cancer. 2003 Dec 1;98(11):2483-7. Links Comment in: Cancer. 2004 Jun 1;100(11):2486-7; author reply 2487-8. Imatinib mesylate causes hypopigmentation in the skin. Tsao AS, Kantarjian H, Cortes J, O'Brien S, Talpaz M. Medical Oncology Fellowship Program, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. BACKGROUND: Imatinib mesylate is a tyrosine kinase inhibitor that targets the BCR-ABL protein in CML, c-kit (KIT) and platelet-derived growth factor receptors. In clinical trials with imatinib mesylate, common side effects of nausea, emesis, diarrhea, periorbital edema, fluid retention, and myelosuppression have been documented. METHODS: In this case series, the authors describe unique clinical findings of skin hypopigmentation in six patients with CML who were treated with imatinib mesylate. RESULTS: Most patients developed onset of skin hypopigmentation within the first month of treatment and all of the patients experienced additional drug toxicity. Despite patient susceptibility to toxicity, the presence of hypopigmentation did not appear to predict leukemic cell response or clinical outcome. All six patients established a hematologic response but only two patients had a complete cytogenetic response. Imatinib mesylate induced hypopigmentation also appeared to be reversible and potentially dose related. CONCLUSION: Skin hypopigmentation is a benign side effect from imatinib mesylate treatment that appears to be reversible upon discontinuation or dose reduction. Several lines of evidence have previously reported that KIT and its ligand stem cell factor (SCF) have a regulatory role in melanocyte development and survival, suggesting a rational mechanism of action for imatinib mesylate in the pathogenesis of hypopigmentation. The signal transduction mechanism currently is believed to involve SCF ligand binding of KIT and downstream activation of MAP kinase (Erk-2). Microphthalmia (Mi), a basic helix-loop-helix leucine zipper (bHLHZip) transcription factor, is phosphorylated by MAP kinase at a serine residue (S73). Once phosphorylated, Mi transactivates the tyrosine pigmentation gene promoter and affects pigment production. Pediatr Dermatol. 2006 Mar-Apr;23(2):175-8. Links Vitiligo-like lesions and diffuse lightening of the skin in a pediatric patient treated with imatinib mesylate: a noninvasive colorimetric assessment. Brazzelli V, Roveda E, Prestinari F, Barbagallo T, Bellani E, Trevisan V, Rona C, Locatelli F, Zecca M, Borroni G. Department of Human and Hereditary Pathology, Institute of Dermatology, University of Parvia, Parvia, Italy. [EMAIL PROTECTED] Imatinib mesylate is a drug that has been recently approved for the treatment for chronic myeloid leukemia. It acts as a potent and selective inhibitor of BCR-ABL tyrosine kinase. It also inhibits both c-kit and platelet-derived growth factor receptor tyrosine kinases. Hypopigmentation of the skin in patients receiving this drug has been recently reported. We report a 17-year-old Caucasian patient affected by chronic myeloid leukemia in therapy with imatinib mesylate who developed hypopigmented vitiligo-like patches and generalized lightening of the skin. In order to evaluate the lightening observed clinically, we measured the progressive skin color hypopigmentation by using a colorimeter over several months. The colorimetric evaluation confirmed the generalized and gradual lightening of patient's skin over treatment with imatinib mesylate. We believe that this is the first reported instance of vitiligo-like lesions in a pediatric patient treated with imatinib mesylate, and the second in a Caucasian patient. --~--~-~--~~~---~--~~ [CMLHope] A support group of http://cmlhope.com - You received this message because you are subscribed to the Google Groups CMLHope group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~--~~~~--~~--~--~---
[CMLHope] Re: Chat Reminder - This Evening - 9:00 PM
please remove me from this listthanksZavie miller [EMAIL PROTECTED] wrote: Chat Reminder - This Evening - 9:00 PMPhoto - Boating on the Ottawa River Do you Yahoo!? Everyone is raving about the all-new Yahoo! Mail Beta. --~--~-~--~~~---~--~~ [CMLHope] A support group of http://cmlhope.com - You received this message because you are subscribed to the Google Groups CMLHope group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~--~~~~--~~--~--~---
[CMLHope] Re: 11 new messages in 6 topics - digest
This message has been processed by Symantec's AntiVirus Technology. Unknown.data was not scanned for viruses because too many nested levels of files were found. For more information on antivirus tips and technology, visit http://ses.symantec.com/ --~--~-~--~~~---~--~~ [CMLHope] A support group of http://cmlhope.com - You received this message because you are subscribed to the Google Groups CMLHope group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~--~~~~--~~--~--~--- ---BeginMessage--- Allyson Kay I had to weigh in on your messages. I am 5 1/2 years on Gleevec and am grateful to still be here, but struggle with all the side-effects like everyone else. Over those years the Gleevec has eaten away the outside (epidermis) layer of skin. That is why I am always freezing anddraw blood every time I bump something. The same goes for being in the sun without sunscreen - burn. I also desperately want to rid myself of looking pale as a dead man. I am now trying a new moisturizer and tanner. It seems to be working on my face and legs. I forget the name (Gleevec related loss of memory). Try it. Dave -- Original message -- From: CMLHope group [EMAIL PROTECTED] This message has been processed by Symantec's AntiVirus Technology. Unknown.data was not scanned for viruses because too many nested levels of files were found.For more information on antivirus tips and technology, visit http://ses.symantec.com/ ---BeginMessage--- ---BeginMessage--- CMLHope http://groups.google.com/group/CMLHope CMLHope@googlegroups.com Today's topics: * white skin/Allyson - 3 messages, 3 authors http://groups.google.com/group/CMLHope/browse_thread/thread/9d8e5d22dee6ae3a * white skin - 3 messages, 3 authors http://groups.google.com/group/CMLHope/browse_thread/thread/f665684d89d35b5 * Chat Reminder - This Evening - 9:00 PM - 1 messages, 1 author http://groups.google.com/group/CMLHope/browse_thread/thread/5ded27ec98de1fb2 * Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/ lymphoma agents against human leukemia/lymphoma cell lines. - 1 messages, 1 author http://groups.google.com/group/CMLHope/browse_thread/thread/c6d63fecb7680478 * City of Hope making strides in understanding the cause of leukemia - 1 messages, 1 author http://groups.google.com/group/CMLHope/browse_thread/thread/c297a657c2a80a03 * heart murmur - 2 messages, 2 authors http://groups.google.com/group/CMLHope/browse_thread/thread/e5dcd765719fff99 == TOPIC: white skin/Allyson http://groups.google.com/group/CMLHope/browse_thread/thread/9d8e5d22dee6ae3a == == 1 of 3 == Date: Tues, Aug 1 2006 8:17 am From: Terry Dailey Allyson and Katy, I am half irish and half American Indian and I also am pale, though I do tan very easy. I am not sure how everyone else feels, but if I am out in the hot sun for very long it starts to feel like I am in a mircowave..lol. It was a running joke for a while in my family that you could watch me and I would become pale then back to normal color right before you eyes. I also have black hair so that does not help either. Along with dark circles under my eyes. Now I do avoid being out in the sun simply because I can't handle the heat at all. I do need to disclose I am into sort of the goth look so for me being pale is not a problem..rotfl. I have been told not to be out in the sun for long periods which suits me just fine. I would check with your doctor Allyson, but I do know their are rub on cremes that will give you a tan without being in the sun. My lady use to get what they call mystic tan. It is a booth at a tanning salon here in our area that gives you a spray on tan. It is kind of funny because when we have been out together we have had commits that we look like a barbie doll and a vampire..hehe. That is sort of ironic and me with my dark humor can't help but laugh because I actually love vampire movies and I end up with a blood disorder..rotl. Anyway Allyson, check with your doctor first but that rub on or spray on stuff might help without you having to be in the sun. Terry On 7/31/06, [EMAIL PROTECTED] [EMAIL PROTECTED] wrote: Dear Allyson, I have never heard that it is bad to get in the sun while taking gleevec just that it makes you more susceptible to burning so you have to be careful. I have attached a pic of me (hope it comes thru and you can see it) which goes to prove you can take gleevec and *still *get a tan! Hugs, Katy p.s... if the pic
[CMLHope] questions re trials son-in-law with cml
To anyone with up-to-date info on trials: My friend Priscilla had to stop the bms trial because she had to go on coumadin. She's been off medicine for 3 mos. She's still in remission but the percentage of PH has increased is expected to gradually increase over time. She knows of other trials will be going back to MD Anderson in 2 weeks. So can you give some help as to what questions she could/should ask about SKI 606 (in phase 2) INNO 406 (in phase 1) AMN Thanks for any info insights here. Now for the truth-is-stranger-than-fiction dept.: My son-in-law was diagnosed with cml 2 wks. ago!! It was found on a routine check for his diabetes. His wbc was at 45 he's started on 400 mg of Gleevec. He my daughter aren't as scared as they could be because of my experience. I'm 6 yrs. from dx 5 yrs. in remission. So hoping my luck will rub off on him. It should. Am going on the 6th annual(my 5th) BMT cruise on the Hudson this Sunday. Will meet up with Cathy Jeff Kramer at this event. It's a happy time. Will report back next week. Ciao Ruth Marcon --~--~-~--~~~---~--~~ [CMLHope] A support group of http://cmlhope.com - You received this message because you are subscribed to the Google Groups CMLHope group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~--~~~~--~~--~--~---
[CMLHope] Re: Muscle Pain
OMW yes! I had so much muscle and bone pain at the beginning it wassnt funny. I still have it but not quite as bad. My neck is the only thing that is consistently hurting since starting gleevec. Hugs, Katy --xanga.com/katybug45 -- Original message -- From: "Priesty" [EMAIL PROTECTED] Hi wondered if anyone can help...my wife has significant muscle pain around her neck and shoulders which is a little reminiscent of pain she had prior to her CML diagnosis. I am aware that bone pain occurs, but does anyone have muscle pain and is it attributable to the CML or Gleevec? let me know cheers steve --~--~-~--~~~---~--~~ [CMLHope] A support group of http://cmlhope.com - You received this message because you are subscribed to the Google Groups CMLHope group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~--~~~~--~~--~--~---
