Re: [CMLHope] Re: Gleevec resistance? Or just a spike?

2016-05-21 Thread Rakesh gmail 
Thank you for the note. Regular blood work is ok. My onco thinks it's a blip. 
Keeping figures crossed!!
Good luck and thanks for the reply..

Best Regards,
Rakesh Doshi (513) 205-7469

> On May 21, 2016, at 10:27 AM, 'Icandoallttc' via CMLHope 
>  wrote:
> 
> Hi Raj
> I was in Gleevec for 5 years and then it quit working for me. My platelets 
> and WBC shot up really high. I was put in Tasigna but it never worked for me. 
> Then I went in sprycel and it worked for a few years and put me in remission. 
> It quit working and again my platelets and WBC shot up.  I'm on Ponatinib now 
> and doing really good in it.  Make sure not to do proton pump inhibitors 
> while on tkis. 
> How are your regular blood results. 
> Good luck. 
> 
> 
> My Motto: Faith and Pills❤️
> With Jeanie 18,s Chi
> Dx 1/2004. CML Leukemia
> Started Gleevec 2/2004
> Started Tasigna  9/2009
> Started Sprycel 11/2009
> Started Ponatinib January 2015
> Dr Balducci Moffitt Cancer Center
> 
>> On May 19, 2016, at 12:10 AM, Richard H  wrote:
>> 
>> When I have never had a long response of 0.000  response.  I was off Gleevec 
>> for 6 1/2 years, when had to go back on Gleevec.  I have actually  reduced 
>> Gleevec to 300mg because CML likes to to work on my blood.  I run from 0.000 
>> to 0.00.3 on my Bcd-abl every 3-6 months.  It is not being called 
>> resistance, but my controlled CML world seems to stay very controlled at 
>> this point.  So if they put you on Gleevec again it should be Okay.  When I 
>> went back on 400 mg of Gleevec it started decreasing my hemg. and I was 
>> headed for more transfusions.  When my ONC lowered it to 300mg we could get 
>> Procrit to build my hemg so that I don't have to have a transfusion.   I was 
>> diagnosed in 2002.
>> 
>> Keep a positive mind and know that will help to pass this bump in the road.  
>> Gleevec has the most history for our ONC to work with and that is the reason 
>> I have remained on Gleevec,  Other health problems makes the newer drugs  
>> make changing to them not the best choice.
>> 
>> Richard H.
>> 
>>> On Wednesday, May 18, 2016 at 8:05:48 PM UTC-5, Raj wrote:
>>> Hello All,
>>> I am new to the group. Hope you can help answer my question. 
>>> History: I was diagnosed CML  in 2001. After 2-3 years On gleevec 400mg, I 
>>> was in major molecular response and then undetectable (0.000) for around > 
>>> 10 years or so..
>>> Now suddenly last month in my last Bcd-abl it showed that I am 
>>> 0.018 and repeating it after a month, it's 0.021 so little bit higher than 
>>> last one..
>>> Is it considered gleevec resistance? Where I need to switch?
>>> BTW:
>>> I missed 3 doses or so in the last month and that is 
>>> Where it (Bcd-abl by PCR) came 0.018 but not sure if 3 days can be that 
>>> critical. Also I don't take medicine at the same time sometimes with 
>>> breakfast sometimes with late lunch.  Can that suddenly change the response?
>>> 
>>> Any thoughts or similar situation insight is much appreciated..
>>> Thanks
>>> Raj
>>> 
>> 
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Re: [CMLHope] Re: Gleevec resistance? Or just a spike?

2016-05-21 Thread 'Icandoallttc' via CMLHope 
Hi Raj
I was in Gleevec for 5 years and then it quit working for me. My platelets and 
WBC shot up really high. I was put in Tasigna but it never worked for me. Then 
I went in sprycel and it worked for a few years and put me in remission. It 
quit working and again my platelets and WBC shot up.  I'm on Ponatinib now and 
doing really good in it.  Make sure not to do proton pump inhibitors while on 
tkis. 
How are your regular blood results. 
Good luck. 


My Motto: Faith and Pills❤️
With Jeanie 18,s Chi
Dx 1/2004. CML Leukemia
Started Gleevec 2/2004
Started Tasigna  9/2009
Started Sprycel 11/2009
Started Ponatinib January 2015
Dr Balducci Moffitt Cancer Center

> On May 19, 2016, at 12:10 AM, Richard H  wrote:
> 
> When I have never had a long response of 0.000  response.  I was off Gleevec 
> for 6 1/2 years, when had to go back on Gleevec.  I have actually  reduced 
> Gleevec to 300mg because CML likes to to work on my blood.  I run from 0.000 
> to 0.00.3 on my Bcd-abl every 3-6 months.  It is not being called resistance, 
> but my controlled CML world seems to stay very controlled at this point.  So 
> if they put you on Gleevec again it should be Okay.  When I went back on 400 
> mg of Gleevec it started decreasing my hemg. and I was headed for more 
> transfusions.  When my ONC lowered it to 300mg we could get Procrit to build 
> my hemg so that I don't have to have a transfusion.   I was diagnosed in 2002.
> 
> Keep a positive mind and know that will help to pass this bump in the road.  
> Gleevec has the most history for our ONC to work with and that is the reason 
> I have remained on Gleevec,  Other health problems makes the newer drugs  
> make changing to them not the best choice.
> 
> Richard H.
> 
>> On Wednesday, May 18, 2016 at 8:05:48 PM UTC-5, Raj wrote:
>> Hello All,
>> I am new to the group. Hope you can help answer my question. 
>> History: I was diagnosed CML  in 2001. After 2-3 years On gleevec 400mg, I 
>> was in major molecular response and then undetectable (0.000) for around > 
>> 10 years or so..
>> Now suddenly last month in my last Bcd-abl it showed that I am 
>> 0.018 and repeating it after a month, it's 0.021 so little bit higher than 
>> last one..
>> Is it considered gleevec resistance? Where I need to switch?
>> BTW:
>> I missed 3 doses or so in the last month and that is 
>> Where it (Bcd-abl by PCR) came 0.018 but not sure if 3 days can be that 
>> critical. Also I don't take medicine at the same time sometimes with 
>> breakfast sometimes with late lunch.  Can that suddenly change the response?
>> 
>> Any thoughts or similar situation insight is much appreciated..
>> Thanks
>> Raj
>> 
> 
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> -
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[CMLHope] Re: Gleevec resistance? Or just a spike?

2016-05-18 Thread Richard H 
When I have never had a long response of 0.000  response.  I was off 
Gleevec for 6 1/2 years, when had to go back on Gleevec.  I have actually  
reduced Gleevec to 300mg because CML likes to to work on my blood.  I run 
from 0.000 to 0.00.3 on my Bcd-abl every 3-6 months.  It is not being 
called resistance, but my controlled CML world seems to stay very 
controlled at this point.  So if they put you on Gleevec again it should be 
Okay.  When I went back on 400 mg of Gleevec it started decreasing my hemg. 
and I was headed for more transfusions.  When my ONC lowered it to 300mg we 
could get Procrit to build my hemg so that I don't have to have a 
transfusion.   I was diagnosed in 2002.

Keep a positive mind and know that will help to pass this bump in the 
road.  Gleevec has the most history for our ONC to work with and that is 
the reason I have remained on Gleevec,  Other health problems makes the 
newer drugs  make changing to them not the best choice.

Richard H.

On Wednesday, May 18, 2016 at 8:05:48 PM UTC-5, Raj wrote:
>
> Hello All,
> I am new to the group. Hope you can help answer my question. 
> History: I was diagnosed CML  in 2001. After 2-3 years On gleevec 400mg, I 
> was in major molecular response and then undetectable (0.000) for around > 
> 10 years or so..
> Now suddenly last month in my last Bcd-abl it showed that I am 
> 0.018 and repeating it after a month, it's 0.021 so little bit higher than 
> last one..
> Is it considered gleevec resistance? Where I need to switch?
>
> BTW:
> I missed 3 doses or so in the last month and that is 
> Where it (Bcd-abl by PCR) came 0.018 but not sure if 3 days can be that 
> critical. Also I don't take medicine at the same time sometimes with 
> breakfast sometimes with late lunch.  Can that suddenly change the 
> response? 
>
> Any thoughts or similar situation insight is much appreciated..
> Thanks
> Raj
>
>

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