Re: [CMLHope] Anyone aware that Glivic and Panadol pain tablets taken together will create extensive Liver damage

2010-10-04 Thread Chuck 
Check with your Oncologist and/or pharmacist they should give you the best
answer.

On Sun, Oct 3, 2010 at 9:36 PM, Rob  wrote:

> Panadol has acetaminophen in it. For many years it has been cautioned to
> limit acetaminophen when taking Gleevec.
>
> Rob
>
> On Sun, Oct 3, 2010 at 5:57 PM, pjgeary  wrote:
>
>>  *Anyone aware that Glivic and Panadol; or paracetimol pain tablets taken
>> together will create extensive Liver damage*
>>
>> * *
>>
>> *Any data, I am being advised by my Pharmacists to stop immediately as
>> their syatems are red carding this *
>>
>> * *
>>
>> *Any news anywhere *
>>
>> * *
>>
>>
>>
>>
>>  --
>>
>> *From:* cmlhope@googlegroups.com [mailto:cmlh...@googlegroups.com] *On
>> Behalf Of 
>> *cmlhope+nore...@googlegroups.com
>> *Sent:* Sunday, October 03, 2010 11:17 PM
>> *To:* Digest Recipients
>> *Subject:* [CMLHope] Digest for cmlhope@googlegroups.com - 1 Message in 1
>> Topic
>>
>>
>>
>>   Today's Topic Summary
>>
>> Group: http://groups.google.com/group/cmlhope/topics
>>
>>- Optimum Sprycel 
>> dose<#12b74e221bae15aa_12b7450587749468_group_thread_0>[1 Update]
>>
>>   Topic: Optimum Sprycel 
>> dose
>>
>> *peg * Oct 02 01:18PM -0700 
>> ^<#12b74e221bae15aa_12b7450587749468_digest_top>
>>
>>
>> Okay... for Beth and those waiting for the outcome of my meeting with
>> the doc that did Sprycel developemental research...here it is:
>>
>> 100mg IS the recommended dose. Does he have patients on less?...
>> Yes...and here is his criteria for reducing the dose:
>>
>> 1. Side effects (he says all side effects on this drug are reversible
>> with reduction or discontinuation)...or...2. Zero achieved and
>> maintained on PCR...verified at least once with BMB.
>>
>> In regard to starting at a lower dose and "tapering" up to 100mg, he
>> said he does not understand why MD's would want to advise their
>> patients to do this, and cautioned against it. He understands that
>> the thought is that it gives the body a chance to "adjust" however, he
>> feels that it also gives the chromosomes a chance to become resistant
>> and could result in Sprycel not being effective. Sort of the same way
>> that taking less of an antibiotic than you would need to overcome an
>> infection allows the infection to become resistant to the antibiotic.
>>
>> For those who are changing from Gleevec because of serious GI side
>> effects and are concerned that Sprycel might be the same... he said
>> that Gleevec is well recognized as the cause of severe gastritis and
>> severe diarrhea in many folks. While there have been some incidents of
>> Colitis with Sprycel, not many, and generally speaking most folks will
>> not have any serious GI side effects on Sprycel. However, a break
>> between the two is recommended to allow GI irritation from Gleevec to
>> settle before introducing Sprycel.
>>
>> In regard to pain medications for headache, etc Contrary to
>> popular belief, with Sprycel, Tylenol is OKAY! However, Aspirin,
>> Ibuprofen, Advil, Motrin, Aleve, Naproxin Sodium, or narcotics
>> containing any of these ARE NOT OKAY. They can thin the blood too
>> much when combined with Sprycel. Caution must be taken when adding
>> any med to Sprycel that can thin the blood. In my case, I do
>> occassionally use Celebrex, which can cause the same problem, however,
>> he said it is probably okay as long as my platelets are normal and I
>> only use it occassionally.
>>
>> He believes that current research will soon produce something better
>> than the current TKI's but for now both 2nd gen TKI's, Tasigna and
>> Sprycel, are stronger than Gleevec and should produce better results
>> at supressing CML in more people.
>>
>> Hope sharing this is helpful to you.
>>
>> Keep the faith!
>> peg
>>
>>
>>
>> --
>> [CMLHope]
>> A support group of http://cmlhope.com
>> -
>>
>> You received this message because you are subscribed to the Google Groups
>> "CMLHope" group.
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>> For more options, visit this group at
>> http://groups.google.com/group/CMLHope
>>
>>
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>> signature database 5500 (20101003) __
>>
>> The message was checked by ESET NOD32 Antivirus.
>>
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>>
>> --
>> [CMLHope]
>> A support group of http://cmlhope.com
>> -
>>
>> You received this message because you are subscribed to the Google Groups
>> "CMLHope" group.
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>
>
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Re: [CMLHope] Anyone aware that Glivic and Panadol pain tablets taken together will create extensive Liver damage

2010-10-03 Thread Rob 
Panadol has acetaminophen in it. For many years it has been cautioned to
limit acetaminophen when taking Gleevec.

Rob

On Sun, Oct 3, 2010 at 5:57 PM, pjgeary  wrote:

>  *Anyone aware that Glivic and Panadol; or paracetimol pain tablets taken
> together will create extensive Liver damage*
>
> * *
>
> *Any data, I am being advised by my Pharmacists to stop immediately as
> their syatems are red carding this *
>
> * *
>
> *Any news anywhere *
>
> * *
>
>
>
>
>  --
>
> *From:* cmlhope@googlegroups.com [mailto:cmlh...@googlegroups.com] *On
> Behalf Of 
> *cmlhope+nore...@googlegroups.com
> *Sent:* Sunday, October 03, 2010 11:17 PM
> *To:* Digest Recipients
> *Subject:* [CMLHope] Digest for cmlhope@googlegroups.com - 1 Message in 1
> Topic
>
>
>
>   Today's Topic Summary
>
> Group: http://groups.google.com/group/cmlhope/topics
>
>- Optimum Sprycel dose <#12b7450587749468_group_thread_0> [1 Update]
>
>   Topic: Optimum Sprycel 
> dose
>
> *peg * Oct 02 01:18PM -0700 
> ^<#12b7450587749468_digest_top>
>
>
> Okay... for Beth and those waiting for the outcome of my meeting with
> the doc that did Sprycel developemental research...here it is:
>
> 100mg IS the recommended dose. Does he have patients on less?...
> Yes...and here is his criteria for reducing the dose:
>
> 1. Side effects (he says all side effects on this drug are reversible
> with reduction or discontinuation)...or...2. Zero achieved and
> maintained on PCR...verified at least once with BMB.
>
> In regard to starting at a lower dose and "tapering" up to 100mg, he
> said he does not understand why MD's would want to advise their
> patients to do this, and cautioned against it. He understands that
> the thought is that it gives the body a chance to "adjust" however, he
> feels that it also gives the chromosomes a chance to become resistant
> and could result in Sprycel not being effective. Sort of the same way
> that taking less of an antibiotic than you would need to overcome an
> infection allows the infection to become resistant to the antibiotic.
>
> For those who are changing from Gleevec because of serious GI side
> effects and are concerned that Sprycel might be the same... he said
> that Gleevec is well recognized as the cause of severe gastritis and
> severe diarrhea in many folks. While there have been some incidents of
> Colitis with Sprycel, not many, and generally speaking most folks will
> not have any serious GI side effects on Sprycel. However, a break
> between the two is recommended to allow GI irritation from Gleevec to
> settle before introducing Sprycel.
>
> In regard to pain medications for headache, etc Contrary to
> popular belief, with Sprycel, Tylenol is OKAY! However, Aspirin,
> Ibuprofen, Advil, Motrin, Aleve, Naproxin Sodium, or narcotics
> containing any of these ARE NOT OKAY. They can thin the blood too
> much when combined with Sprycel. Caution must be taken when adding
> any med to Sprycel that can thin the blood. In my case, I do
> occassionally use Celebrex, which can cause the same problem, however,
> he said it is probably okay as long as my platelets are normal and I
> only use it occassionally.
>
> He believes that current research will soon produce something better
> than the current TKI's but for now both 2nd gen TKI's, Tasigna and
> Sprycel, are stronger than Gleevec and should produce better results
> at supressing CML in more people.
>
> Hope sharing this is helpful to you.
>
> Keep the faith!
> peg
>
>
>
> --
> [CMLHope]
> A support group of http://cmlhope.com
> -
>
> You received this message because you are subscribed to the Google Groups
> "CMLHope" group.
> To post to this group, send email to CMLHope@googlegroups.com
> To unsubscribe from this group, send email to
> cmlhope-unsubscr...@googlegroups.com
> For more options, visit this group at
> http://groups.google.com/group/CMLHope
>
>
> __ Information from ESET NOD32 Antivirus, version of virus
> signature database 5500 (20101003) __
>
> The message was checked by ESET NOD32 Antivirus.
>
> http://www.eset.com
>
> --
> [CMLHope]
> A support group of http://cmlhope.com
> -
>
> You received this message because you are subscribed to the Google Groups
> "CMLHope" group.
> To post to this group, send email to CMLHope@googlegroups.com
> To unsubscribe from this group, send email to
> cmlhope-unsubscr...@googlegroups.com
> For more options, visit this group at
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RE: [CMLHope] Anyone aware that Glivic and Panadol pain tablets taken together will create extensive Liver damage

2010-10-03 Thread Pat Elliott 
The product package information shows that paracetamol should not be taken
with Glivic/Gleevec. You can find more information through a Google search
as well. 
Pat in Phoenix
 
Some medicines and Glivec may interfere with each other. These include many
medicines that are eliminated from the body through the liver: 
St. John's wort, a herbal medicine found in many products that you can buy
without a prescription
paracetamol, a medicine found in many common pain relievers and cold
remedies (e.g. PanadolR, PanadeineR, CodralR, TylenolR) 
antibiotic medicines such as rifampicin, ketoconazole, erythromycin,
clarithromycin, itraconazole
antiviral medicines used to treat HIV/AIDS
dexamethasone, a steroid medicine
medicines for high cholesterol, such as simvastatin
medicines used to treat epilepsy, such as phenytoin, carbamazepine,
phenobarbitone
warfarin, a medicine used to prevent blood clots
some medicines used to treat mental disorders and depression
some medicines used to treat high blood pressure and heart problems 
cyclosporin
You may need to take different amounts of these medicines or you may need to
take different medicines. Your doctor and pharmacist have more information. 
If you have not told your doctor about any of these things, tell him/her
before you start taking this medicine.
 
 
  _  

From: cmlhope@googlegroups.com [mailto:cmlh...@googlegroups.com] On Behalf
Of pjgeary
Sent: Sunday, October 03, 2010 3:57 PM
To: cmlhope@googlegroups.com
Subject: [CMLHope] Anyone aware that Glivic and Panadol pain tablets taken
together will create extensive Liver damage
 
Anyone aware that Glivic and Panadol; or paracetimol pain tablets taken
together will create extensive Liver damage
 
Any data, I am being advised by my Pharmacists to stop immediately as their
syatems are red carding this 
 
Any news anywhere 
 
 
 
  _  

From: cmlhope@googlegroups.com [mailto:cmlh...@googlegroups.com] On Behalf
Of cmlhope+nore...@googlegroups.com
Sent: Sunday, October 03, 2010 11:17 PM
To: Digest Recipients
Subject: [CMLHope] Digest for cmlhope@googlegroups.com - 1 Message in 1
Topic
 
  Today's Topic Summary
Group: http://groups.google.com/group/cmlhope/topics
*   Optimum Sprycel dose <>  [1 Update]
 Topic: Optimum Sprycel dose
 
peg  Oct 02 01:18PM -0700 ^ <> 
 
Okay... for Beth and those waiting for the outcome of my meeting with
the doc that did Sprycel developemental research...here it is:
 
100mg IS the recommended dose. Does he have patients on less?...
Yes...and here is his criteria for reducing the dose:
 
1. Side effects (he says all side effects on this drug are reversible
with reduction or discontinuation)...or...2. Zero achieved and
maintained on PCR...verified at least once with BMB.
 
In regard to starting at a lower dose and "tapering" up to 100mg, he
said he does not understand why MD's would want to advise their
patients to do this, and cautioned against it. He understands that
the thought is that it gives the body a chance to "adjust" however, he
feels that it also gives the chromosomes a chance to become resistant
and could result in Sprycel not being effective. Sort of the same way
that taking less of an antibiotic than you would need to overcome an
infection allows the infection to become resistant to the antibiotic.
 
For those who are changing from Gleevec because of serious GI side
effects and are concerned that Sprycel might be the same... he said
that Gleevec is well recognized as the cause of severe gastritis and
severe diarrhea in many folks. While there have been some incidents of
Colitis with Sprycel, not many, and generally speaking most folks will
not have any serious GI side effects on Sprycel. However, a break
between the two is recommended to allow GI irritation from Gleevec to
settle before introducing Sprycel.
 
In regard to pain medications for headache, etc Contrary to
popular belief, with Sprycel, Tylenol is OKAY! However, Aspirin,
Ibuprofen, Advil, Motrin, Aleve, Naproxin Sodium, or narcotics
containing any of these ARE NOT OKAY. They can thin the blood too
much when combined with Sprycel. Caution must be taken when adding
any med to Sprycel that can thin the blood. In my case, I do
occassionally use Celebrex, which can cause the same problem, however,
he said it is probably okay as long as my platelets are normal and I
only use it occassionally.
 
He believes that current research will soon produce something better
than the current TKI's but for now both 2nd gen TKI's, Tasigna and
Sprycel, are stronger than Gleevec and should produce better results
at supressing CML in more people.
 
Hope sharing this is helpful to you.
 
Keep the faith!
peg
 
-- 
[CMLHope]
A support group of http://cmlhope.com
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