I have managed to compile the latest git version of twinkle by omitting a few codecs.
I used cmake .. -DWITH_ALSA=On -DWITH_SPEEX=On -DWITH_ILBC=Off -DWITH_ZRTP=Off -DWITH_G729=Off -DWITH_QT5=On This seems to have produced a working twinkle and so far there have been no problems with ALSA. But I have done very little testing so far. So it looks as if it should be possible to get a working version in Debian.