Bug#283695: ITP: mssstest -- Normalisation of EDSS disease score of patients with Multiple Sclerosis

[sean finney]

hi steffen,

On Tue, Nov 30, 2004 at 07:31:33PM +0100, Steffen Moeller wrote:
> Suppose one is interested in determining whether the genotype at some


the description is a bit long.  i think the second paragraph would
be appropriate.

> MSSStest is a program for implementing the method described in the
> article The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et
> al. (2004), accepted for publication by Neurology. It calculates MSSS
> scores and uses these scores to test for differences between disease
> progression rates in different groups defined by genotype at some locus.

> The application of this predictor is technically not constrained to
> Multiple Sclerosis which justifies the presentation as a Debian package.

even if it were, i don't see why it wouldn't justify a debian package.
especially given some of the other stuff being proposed recently (i.e.:
the ITP on hot-babe)

> I have created a package and hope for a sponsor - which is of course a
> bit tricky for non-DFSG-compliant software.

have you tried to politely persuade upstream to change the terms of
their license?  it may be that they put that limitation on their
software not realizing its implications, or that perhaps there exists
another dfsg compliant license that would meet their needs as well
as debian's.


sean

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Bug#283695: ITP: mssstest -- Normalisation of EDSS disease score of patients with Multiple Sclerosis

[Steffen Moeller]

Package: wnpp
Severity: wishlist


* Package name: mssstest
  Version : 2.0
  Upstream Author : Shaun Seaman and Richard Roxburgh <[EMAIL PROTECTED]>
* URL : http://www-gene.cimr.cam.ac.uk/MSgenetics/GAMES/MSSS
* License : public domain but must not be sold -> non-free
  Description : Normalisation of EDSS disease score of patients with 
Multiple Sclerosis

Suppose one is interested in determining whether the genotype at some
locus of interest affects the rate of progression of disease of people
with Multiple Sclerosis (MS). One method would be to calculate the mean
EDSS score in patients with each of the genotypes and test whether they
are significantly different. However, this approach is inefficient if
patients have their EDSS assessed at different durations of disease, as
patients who have had MS longer typically have higher EDSS scores
regardless of their genotype. By adjusting for duration, a more powerful
test can be developed.

MSSStest is a program for implementing the method described in the
article The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et
al. (2004), accepted for publication by Neurology. It calculates MSSS
scores and uses these scores to test for differences between disease
progression rates in different groups defined by genotype at some locus.
A brief description of the method is given below.

The application of this predictor is technically not constrained to
Multiple Sclerosis which justifies the presentation as a Debian package.

I have created a package and hope for a sponsor - which is of course a
bit tricky for non-DFSG-compliant software.

Kind regards

Steffen

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